Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Richard Appleton"'
Publikováno v:
Anaesthesia & Intensive Care Medicine. 22:799-806
Pain, agitation and delirium are common during critical illness and are associated with many adverse consequences. A key aim of critical care is the facilitation of a calm, comfortable patient who can interact with their family and staff. Intensive c
Publikováno v:
Open access emergency medicine : OAEM. 14
Convulsive status epilepticus (CSE) is the most common neurological emergency in children and the second most common neurological emergency in adults. Mortality is low, but morbidity, including neuro-disability, learning difficulties, and a de-novo e
Autor:
Anthony G Marson, Girvan Burnside, Richard Appleton, Dave Smith, John Paul Leach, Graeme Sills, Catrin Tudur-Smith, Catrin O Plumpton, Dyfrig A Hughes, Paula R Williamson, Gus Baker, Silviya Balabanova, Claire Taylor, Richard Brown, Dan Hindley, Stephen Howell, Melissa Maguire, Rajiv Mohanraj, Philip EM Smith
Publikováno v:
Health technology assessment (Winchester, England)
Health Technology Assessment, Vol 25, Iss 75 (2021)
Health Technology Assessment, Vol 25, Iss 75 (2021)
Background Levetiracetam (Keppra®, UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran®, Eisai Co. Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for generalised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a690f92d19bb56b714480cab3eb3c0
https://eprints.gla.ac.uk/262507/1/262507.pdf
https://eprints.gla.ac.uk/262507/1/262507.pdf
Autor:
Ian Wadsworth, Lisa V. Hampson, Thomas Jaki, Richard Appleton, Anthony G Marson, Graeme J. Sills
Publikováno v:
Journal of the Royal Statistical Society Series A: Statistics in Society. 183:515-534
Summary When developing a new medicine for children, the potential to extrapolate from adult efficacy data is well recognized. However, significant assumptions about the similarity of adults and children are needed for extrapolations to be biological
Autor:
Elizabeth Lee, Anand Iyer, Amy Humphreys, Carrol Gamble, Richard Appleton, Helen Hickey, Joanne Noblet, Mark D Lyttle, Shrouk Messahel, Louise Roper, Naomi Rainford, Kerry Woolfall
Publikováno v:
EMERGENCY MEDICINE JOURNAL
Emergency Medicine Journal : EMJ
Emergency Medicine Journal : EMJ
BackgroundAlternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior consent (RWPC) involves practitioners approaching parents after an intervention has been given and seek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a727f999e78c76003e129ffed6ea530
Autor:
Richard Appleton, Praveen Jauhari
Publikováno v:
Paediatrics and Child Health. 28:480-487
The epilepsies of childhood are a markedly heterogeneous group of diseases with different presentations, outcomes and aetiologies. There is no single, gold-standard investigation that will unequivocally diagnose an epilepsy. The range of aetiologies
Autor:
Paul Tate, Anand Iyer, Sarah Potter, Nadia Al Najjar, Vicki Evans, Richard Appleton, Amy Humphreys, Mark D Lyttle, Naomi Rainford, Elizabeth Lee, Kerry Woolfall, Helen Hickey, Shrouk Messahel, Carrol Gamble, Louise Roper, Joanne Noblet
Publikováno v:
Health Technology Assessment
Health technology assessment (Winchester, England)
Health Technology Assessment, Vol 24, Iss 58 (2020)
Health Technol Assess
Health technology assessment (Winchester, England)
Health Technology Assessment, Vol 24, Iss 58 (2020)
Health Technol Assess
Background Convulsive status epilepticus is the most common neurological emergency in children. Its management is important to avoid or minimise neurological morbidity and death. The current first-choice second-line drug is phenytoin (Epanutin, Pfize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5503576625a8d81ca9b42044ca91409
Autor:
Marvin Johnson, Phil Smith, Dyfrig A. Hughes, Catrin Plumpton, John Paul Leach, Girvan Burnside, Silviya Balabanova, Paula R Williamson, Gus A. Baker, Richard Appleton, Graeme J. Sills, Catrin Tudur-Smith, Claire Taylor, Munir Pirmohamed, Anthony G Marson
Publikováno v:
BMJ Open
BMJ open
BMJ Open, Vol 10, Iss 8 (2020)
BMJ open
BMJ Open, Vol 10, Iss 8 (2020)
IntroductionAntiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Over the past 20 years, a number of new drugs have been approved for National Health Service (NHS) use on the basis of information from short-term trials that demonstrate
Autor:
Mark D Lyttle, Amy Humphreys, Shrouk Messahel, Joanne Noblet, Helen Hickey, Anand Iyer, Richard Appleton, Elizabeth Lee, Naomi Rainford, Kerry Woolfall, Carrol Gamble, Louise Roper
Publikováno v:
Emergency Medicine Journal : EMJ
Emergency Medicine Journal
Emergency Medicine Journal
BackgroundKey challenges to the successful conduct of The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children (EcLiPSE) trial were identified at the pre-trial stage. These included practitioner anxieties about conduc
Publikováno v:
Seizure. 57:66-69
To compare the de novo incidence of Panayiotopoulos syndrome (PS, early-onset childhood occipital epilepsy) and a common epilepsy syndrome, benign epilepsy with centro-temporal spikes (BECTS), in children and young people.The incidence of PS and BECT