Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Raghavendra G. Mirmira"'
Autor:
Shima Nakanishi, Jiannong Li, Anders E. Berglund, Youngchul Kim, Yonghong Zhang, Ling Zhang, Chunying Yang, Jinming Song, Raghavendra G. Mirmira, John L. Cleveland
Publikováno v:
Blood Cancer Discovery.
The MYC oncoprotein is activated in a broad spectrum of human malignancies and transcriptionally reprograms the genome to drive cancer cell growth. Given this, it is unclear if targeting a single effector of MYC will have therapeutic benefit. MYC act
Autor:
Pedro Gonzalez-Menendez, Ira Phadke, Meagan E Olive, Axel Joly, Julien Papoin, Hongxia Yan, Jérémy Galtier, Jessica Platon, Sun Woo Sophie Kang, Kathy L. McGraw, Marie Daumur, Marie Pouzolles, Taisuke Kondo, Stéphanie Boireau, Franciane Paul, David J Young, Sylvain Lamure, Raghavendra G Mirmira, Anu Narla, Guillaume Cartron, Cynthia E. Dunbar, Myriam Boyer-Clavel, Natalie Porat-Shliom, Valerie Dardalhon, Valerie S Zimmermann, Marc Sitbon, Thomas Dever, Narla Mohandas, Lydie M Da Costa, Namrata D. Udeshi, Lionel Blanc, Sandrina Kinet, Naomi Taylor
Publikováno v:
Blood.
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it is not known whether the metabolic regulation of protein synthesis controls HSPC differentiation. Here, we show that SLC7A1/CAT1-dependent arginine uptake and
Autor:
Emily K. Sims, Abhishek Kulkarni, Audrey Hull, Stephanie E. Woerner, Susanne Cabrera, Lucy D. Mastrandrea, Batoul Hammoud, Soumyadeep Sarkar, Ernesto Nakayasu, Teresa L. Mastracci, Susan M. Perkins, Fangqian Ouyang, Bobbie-Jo Webb-Robertson, Jacob Enriquez, Sarah Tersey, Carmella Evans-Molina, Alice Long, J. Lori Blanchfield, Eugene W. Gerner, Raghavendra G. Mirmira, Linda A. DiMeglio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf194459eb879a9aed256fcf023d33bd
https://doi.org/10.2139/ssrn.4417788
https://doi.org/10.2139/ssrn.4417788
Autor:
Soumyadeep Sarkar, John T. Melchior, Hayden R. Henry, Farooq Syed, Raghavendra G. Mirmira, Ernesto S. Nakayasu, Thomas O. Metz
Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Current treatment for Type 1 diabetes (T1D) is centered around insulin supplementation to manage the effects of pancreatic β cell loss. GDF15 is a potential preventative therapy against T1D progression that could work to curb increasin
Autor:
Raghavendra G. Mirmira, Edward Simpson, Farooq Syed, Yunlong Liu, Chih-Chun Lee, Wenting Wu, Chuanpeng Dong, Garrick Chang, Jing Liu, Carmella Evans-Molina, Clayton Seitz, Decio L. Eizirik
Publikováno v:
Diabetes
Alternative splicing (AS) within the β-cell has been proposed as one potential pathway that may exacerbate autoimmunity and unveil novel immunogenic epitopes in type 1 diabetes (T1D). We used a computational strategy to prioritize pathogenic splicin
Publikováno v:
Biomarkers in Diabetes ISBN: 9783031080135
Biomarkers in Diabetes ISBN: 9783030813031
Biomarkers in Diabetes ISBN: 9783030813031
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de41f14006c8c845628794e861d9ae8
https://doi.org/10.1007/978-3-031-08014-2_31
https://doi.org/10.1007/978-3-031-08014-2_31
Autor:
Milene C. Vallejo, Soumyadeep Sarkar, Emily C. Elliott, Hayden R. Henry, Fei Huang, Samuel H. Payne, Sasanka Ramanadham, Emily K. Sims, Thomas O. Metz, Raghavendra G. Mirmira, Ernesto S. Nakayasu
Extracellular vesicles (EVs) play important roles in cell-to-cell communication and are potential biomarkers as they carry markers of their derived tissues and disease signatures. However, obtaining pure EV preparations from biofluids is challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b867502a0a07391a2aab434a340060e4
https://doi.org/10.1101/2022.09.28.509996
https://doi.org/10.1101/2022.09.28.509996
Publikováno v:
Endocrinology. 164(1)
The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to their major molecular insults (loss of immune tolerance and onset of tissue insulin resistance, respectively). However, evidence suggests that dysfunction an
Autor:
FEI HUANG, ABHISHEK KULKARNI, FAROOQ SYED, DAVID J. MALONEY, SARAH A. TERSEY, RAGHAVENDRA G. MIRMIRA
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) has become viewed as an autoimmune disease initiated and propagated by stress responses in islet β cells. The integrated stress response (ISR) is activated upon inflammatory signaling and delimits protein production through the
Publikováno v:
Diabetes. 71
Recent data suggest that stress-induced molecular pathways in the β cell may trigger the display of neoantigens that initiate autoimmunity in type 1 diabetes (T1D) . Polyamines (putrescine, spermidine, and spermine) are biogenic amines that particip