Zobrazeno 1 - 10
of 145
pro vyhledávání: '"R. Mayeux"'
Publikováno v:
Critical Care Clinics, 36, 323-331. W.B. Saunders
Microvascular dysfunction is a frequent complication of many chronic and acute conditions, especially in the critically ill. Moreover, the severity of microvascular alterations is associated with development of organ dysfunction and poor outcome. The
Autor:
Daniel M. Gatti, Gary Larson, Alison H. Harrill, William B. Mattes, Lascelles E. Lyn-Cook, Dahea You, Philip R. Mayeux, Natalie Bell, Laura P. James
Publikováno v:
Toxicol Sci
Zileuton is an orally active inhibitor of leukotriene synthesis for maintenance treatment of asthma, for which clinical usage has been associated with idiosyncratic liver injury. Mechanistic understanding of zileuton toxicity is hampered by the rarit
Publikováno v:
Critical Care Medicine. 44:e711-e720
The mitogen-activated protein kinase/extracellular signal–regulated kinase signaling pathway is an essential component of innate immunity necessary for mediating proinflammatory responses in the setting of sepsis. We previously demonstrated that th
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:228-239
Sepsis is a serious medical condition caused by a severe systemic inflammatory response to a bacterial, fungal, or viral infection that most commonly affects neonates and the elderly. Advances in understanding the pathophysiology of sepsis have resul
Autor:
Asli Ahmed, Hong Wu, Vladimir Lupashin, Coedy Hadden, Philip R. Mayeux, Fusun Kilic, Yicong Li, Anthonya Cooper
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
Scientific Reports
Scientific Reports
Hyperpermeability of the endothelial barrier and resulting microvascular leakage are a hallmark of sepsis. Our studies describe the mechanism by which serotonin (5-HT) regulates the microvascular permeability during sepsis. The plasma 5-HT levels are
Autor:
Gina M. Peloso, Sven J. van derLee, International Genomics of Alzheimer's Project (IGAP), R. Sims, S.J. van derLee, A.C. Naj, C. Bellenguez, N. Badarinarayan, J. Jakobsdottir, B.W. Kunkle, A. Boland, R. Raybould, J.C. Bis, E.R. Martin, B. Grenier‐Boley, S. Heilmann‐Heimbach, V. Chouraki, A.B. Kuzma, K. Sleegers, M. Vronskaya, A. Ruiz, R.R. Graham, R. Olaso, P. Hoffmann, M.L. Grove, B.N. Vardarajan, M. Hiltunen, M.M. Nöthen, C.C. White, K.L. Hamilton‐Nelson, J. Epelbaum, W. Maier, S.H. Choi, G.W. Beecham, C. Dulary, S. Herms, A.V. Smith, C.C. Funk, Derbois, A.J. Forstner, S. Ahmad, H. Li, D. Bacq, D. Harold, C.L. Satizabal, O. Valladares, A. Squassina, R. Thomas, J.A. Brody, L. Qu, P. Sánchez‐Juan, T. Morgan, F.J. Wolters, Y. Zhao, F.S. Garcia, N. Denning, M. Fornage, J. Malamon, M.C.D. Naranjo, E. Majounie, T.H. Mosley, B. Dombroski, D. Wallon, M.K. Lupton, J. Dupuis, P. Whitehead, L. Fratiglioni, C. Medway, X. Jian, S. Mukherjee, L. Keller, K. Brown, H. Lin, L.B. Cantwell, F. Panza, B. McGuinness, S. Moreno‐Grau, J.D. Burgess, V. Solfrizzi, P. Proitsi, H.H. Adams, M. Allen, D. Seripa, P. Pastor, L.A. Cupples, N.D. Price, D. Hannequin, A. Frank‐García, D. Levy, P. Chakrabarty, P. Caffarra, I. Giegling, A.S. Beiser, V. Giedraitis, H. Hampel, M.E. Garcia, X. Wang, L. Lannfelt, P. Mecocci, G. Eiriksdottir, P.K. Crane, F. Pasquier, V. Boccardi, I. Henández, R.C. Barber, M. Scherer, L. Tarraga, P.M. Adams, M. Leber, Y. Chen, M.S. Albert, S. Riedel‐Heller, V. Emilsson, D. Beekly, A. Braae, R. Schmidt, D. Blacker, C. Masullo, H. Schmidt, R.S. Doody, G. Spalletta, W.T. Longstreth Jr., T.J. Fairchild, P. Bossù, O.L. Lopez, M.P. Frosch, E. Sacchinelli, B. Ghetti, Q. Yang, R.M. Huebinger, F. Jessen, S. Li, M.I. Kamboh, J. Morris, O. Sotolongo‐Grau, M.J. Katz, C. Corcoran, M. Dunstan, A. Braddel, C. Thomas, A. Meggy, R. Marshall, A. Gerrish, J. Chapman, M. Aguilar, S. Taylor, M. Hill, M.D. Fairén, A. Hodges, B. Vellas, H. Soininen, I. Kloszewska, M. Daniilidou, J. Uphill, Y. Patel, J.T. Hughes, J. Lord, J. Turton, A.M. Hartmann, R. Cecchetti, C. Fenoglio, M. Serpente, M. Arcaro, C. Caltagirone, M.D. Orfei, A. Ciaramella, S. Pichler, M. Mayhaus, W. Gu, A. Lleó, J. Fortea, R. Blesa, I.S. Barber, K. Brookes, C. Cupidi, R.G. Maletta, D. Carrell, S. Sorbi, S. Moebus, M. Urbano, A. Pilotto, J. Kornhuber, P. Bosco, S. Todd, D. Craig, J. Johnston, M. Gill, B. Lawlor, A. Lynch, N.C. Fox, J. Hardy, ARUK Consortium, R.L. Albin, L.G. Apostolova, S.E. Arnold, S. Asthana, C.S. Atwood, C.T. Baldwin, L.L. Barnes, S. Barral, T.G. Beach, J.T. Becker, E.H. Bigio, T.D. Bird, B.F. Boeve, J.D. Bowen, A. Boxer, J.R. Burke, J.M. Burns, J.D. Buxbaum, N.J. Cairns, C. Cao, C.S. Carlson, C.M. Carlsson, R.M. Carney, M.M. Carrasquillo, S.L. Carroll, C.C. Diaz, H.C. Chui, D.G. Clark, D.H. Cribbs, E.A. Crocco, C. DeCarli, M. Dick, R. Duara, D.A. Evans, K.M. Faber, K.B. Fallon, D.W. Fardo, M.R. Farlow, S. Ferris, T.M. Foroud, D.R. Galasko, M. Gearing, D.H. Geschwind, J.R. Gilbert, N.R. Graff‐Radford, R.C. Green, J.H. Growdon, R.L. Hamilton, L.E. Harrell, L.S. Honig, M.J. Huentelman, C.M. Hulette, B.T. Hyman, G.P. Jarvik, E. Abner, L.W. Jin, G. Jun, A. Karydas, J.A. Kaye, R. Kim, N.W. Kowall, J.H. Kramer, F.M. LaFerla, J.J. Lah, J.B. Leverenz, A.I. Levey, G. Li, A.P. Lieberman, K.L. Lunetta, C.G. Lyketsos, D.C. Marson, F. Martiniuk, D.C. Mash, E. Masliah, W.C. McCormick, S.M. McCurry, A.N. McDavid, A.C. McKee, M. Mesulam, B.L. Miller, C.A. Miller, J.W. Miller, J.C. Morris, J.R. Murrell, A.J. Myers, S. O'Bryant, J.M. Olichney, V.S. Pankratz, J.E. Parisi, H.L. Paulson, W. Perry, E. Peskind, A. Pierce, W.W. Poon, H. Potter, J.F. Quinn, A. Raj, M. Raskind, B. Reisberg, C. Reitz, J.M. Ringman, E.D. Roberson, E. Rogaeva, H.J. Rosen, R.N. Rosenberg, M.A. Sager, A.J. Saykin, J.A. Schneider, L.S. Schneider, W.W. Seeley, A.G. Smith, J.A. Sonnen, S. Spina, R.A. Stern, R.H. Swerdlow, R.E. Tanzi, T.A. Thornton‐Wells, J.Q. Trojanowski, J.C. Troncoso, V.M. Van Deerlin, L.J. Van Eldik, H.V. Vinters, J.P. Vonsattel, S. Weintraub, K.A. Welsh‐Bohmer, K.C. Wilhelmsen, J. Williamson, T.S. Wingo, R.L. Woltjer, C.B. Wright, C.E. Yu, L. Yu, F. Garzia, F. Golamaully, G. Septier, S. Engelborghs, R. Vandenberghe, P.P. De Deyn, C.M. Fernadez, Y.A. Benito, H. Thonberg, C. Forsell, L. Lilius, A. Kinhult‐Stählbom, L. Kilander, R. Brundin, L. Concari, S. Helisalmi, A.M. Koivisto, A. Haapasalo, V. Dermecourt, N. Fievet, O. Hanon, C. Dufouil, A. Brice, K. Ritchie, B. Dubois, J.J. Himali, C.D. Keene, J. Tschanz, A.L. Fitzpatrick, W.A. Kukull, M. Norton, T. Aspelund, E.B. Larson, R. Munger, J.I. Rotter, R.B. Lipton, M.J. Bullido, A. Hofman, T.J. Montine, E. Coto, E. Boerwinkle, R.C. Petersen, V. Alvarez, F. Rivadeneira, E.M. Reiman, M. Gallo, C.J. O'Donnell, J.S. Reisch, A.C. Bruni, D.R. Royall, M. Dichgans, M. Sano, D. Galimberti, P. St George‐Hyslop, E. Scarpini, D.W. Tsuang, M. Mancuso, U. Bonuccelli, A.R. Winslow, A. Daniele, C.K. Wu, GERAD/PERADES, CHARGE, ADGC, EADI, O. Peters, B. Nacmias, M. Riemenschneider, R. Heun, C. Brayne, D.C. Rubinsztein, J. Bras, R. Guerreiro, A. Al‐Chalabi, C.E. Shaw, J. Collinge, D. Mann, M. Tsolaki, J. Clarimón, R. Sussams, S. Lovestone, M.C. O'Donovan, M.J. Owen, T.W. Behrens, S. Mead, A.M. Goate, A.G. Uitterlinden, C. Holmes, C. Cruchaga, M. Ingelsson, D.A. Bennett, J. Powell, T.E. Golde, C. Graff, P.L. De Jager, K. Morgan, N. Ertekin‐Taner, O. Combarros, B.M. Psaty, P. Passmore, S.G. Younkin, C. Berr, V. Gudnason, D. Rujescu, D.W. Dickson, J.F. Dartigues, A.L. DeStefano, S. Ortega‐Cubero, H. Hakonarson, D. Campion, M. Boada, J.K. Kauwe, L.A. Farrer, C. Van Broeckhoven, M.A. Ikram, L. Jones, J.L. Haines, C. Tzourio, L.J. Launer, V. Escott‐Price, R. Mayeux, J.F. Deleuze, N. Amin, P.A. Holmans, M.A. Pericak‐Vance, P. Amouyel, C.M. vanDuijn, A. Ramirez, L.S. Wang, J.C. Lambert, S. Seshadri, J. Williams, G.D. Schellenberg, Anita L. Destefano, Sudha Seshardi
Publikováno v:
Alzheimer's & Dementia: diagnosis, assessment & disease monitoring, 10, 595-598. Elsevier
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 595-598. Elsevier BV
International Genomics of Alzheimer's Project (IGAP) 2018, ' Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease ', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 10, pp. 595-598 . https://doi.org/10.1016/j.dadm.2018.08.008
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 595-598 (2018)
International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI 2018, ' Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease ', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 10, pp. 595-598 . https://doi.org/10.1016/j.dadm.2018.08.008
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, 595-598. Elsevier BV
International Genomics of Alzheimer's Project (IGAP) 2018, ' Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease ', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 10, pp. 595-598 . https://doi.org/10.1016/j.dadm.2018.08.008
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 595-598 (2018)
International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI 2018, ' Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease ', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 10, pp. 595-598 . https://doi.org/10.1016/j.dadm.2018.08.008
Introduction There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de47e54764bffb1fbd7fa7adb637f933
https://pure.eur.nl/en/publications/eb9ba292-2604-42a0-9587-9316f2c1e076
https://pure.eur.nl/en/publications/eb9ba292-2604-42a0-9587-9316f2c1e076
Autor:
Sharda P. Singh, Dala Zakaria, Neriman Gokden, Clark R. Sims, Philip R. Mayeux, Trung C. Nguyen, Shengyu Mu
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 8 (2017)
Frontiers in Pharmacology, Vol 8 (2017)
While the mortality rate associated with sepsis in children has fallen over the years, it still remains unacceptably high. The development of both acute cardiac dysfunction and acute kidney injury during severe sepsis is categorized as type 5 cardior
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F734-F743
Acute kidney injury (AKI) is a complication of sepsis and leads to a high mortality rate. Human and animal studies suggest that mitochondrial dysfunction plays an important role in sepsis-induced multi-organ failure; however, the specific mitochondri
Publikováno v:
Journal of kidney
Sepsis can provoke kidney injury, which increases mortality. Human and animal studies have documented increased renal oxidative injury and mitochondrial damage during sepsis. However, few studies have attempted to dissect specific renal targets and/o
Autor:
Vladimir Lupashin, Yicong Li, Coedy Hadden, Hong Wu, Fusun Kilic, Anthonya Cooper, Philip R. Mayeux, Asli Ahmed
Publikováno v:
Scientific Reports. 6
Hyperpermeability of the endothelial barrier and resulting microvascular leakage are a hallmark of sepsis. Our studies describe the mechanism by which serotonin (5-HT) regulates the microvascular permeability during sepsis. The plasma 5-HT levels are