Zobrazeno 1 - 10
of 473
pro vyhledávání: '"Pedro R. Lowenstein"'
Autor:
Stephen V. Carney, Kaushik Banerjee, Anzar Mujeeb, Brandon Zhu, Santiago Haase, Maria L. Varela, Padma Kadiyala, Claire E. Tronrud, Ziwen Zhu, Devarshi Mukherji, Preethi Gorla, Yilun Sun, Rebecca Tagett, Felipe J. Núñez, Maowu Luo, Weibo Luo, Mats Ljungman, Yayuan Liu, Ziyun Xia, Anna Schwendeman, Tingting Qin, Maureen A. Sartor, Joseph F. Costello, Daniel P. Cahill, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
Clinical Cancer Research. 29:1763-1782
Purpose: Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer th
Autor:
Maria Luisa Varela, Andrea Comba, Syed M Faisal, Anna Argento, Andrea Franson, Marcus N Barissi, Sean Sachdev, Maria G Castro, Pedro R Lowenstein
Publikováno v:
Expert Opinion on Biological Therapy. 23:145-161
High-grade gliomas (HGG) are the most common malignant primary brain tumors in adults, with a median survival of ~18 months. The standard of care (SOC) is maximal safe surgical resection, and radiation therapy with concurrent and adjuvant temozolomid
Publikováno v:
Neuro-Oncology.
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Supplementary Figures and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bec136e20960303ccc970834308449
https://doi.org/10.1158/1078-0432.22725171.v1
https://doi.org/10.1158/1078-0432.22725171.v1
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Table S2. Liquid Chromatography and Mass Spectrometry Measurement of 2-hydroxyglutarate in the Conditioned Media of mIDH1 GCCs untreated, treated with vehicle (DMSO), or mIDH1 inhibitor (AGI-5198 or DS1001b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73915f46862024d3a7fa42ac585a49a1
https://doi.org/10.1158/1078-0432.22725162
https://doi.org/10.1158/1078-0432.22725162
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Purpose:Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3c3c2ce3a6c570ef17acab87c745c3
https://doi.org/10.1158/1078-0432.c.6533038
https://doi.org/10.1158/1078-0432.c.6533038
Autor:
Maria G. Castro, Pedro R. Lowenstein, Daniel P. Cahill, Joseph F. Costello, Maureen A. Sartor, Tingting Qin, Anna Schwendeman, Ziyun Xia, Yayuan Liu, Mats Ljungman, Weibo Luo, Maowu Luo, Felipe J. Núñez, Rebecca Tagett, Yilun Sun, Preethi Gorla, Devarshi Mukherji, Ziwen Zhu, Claire E. Tronrud, Padma Kadiyala, Maria L. Varela, Santiago Haase, Brandon Zhu, Anzar Mujeeb, Kaushik Banerjee, Stephen V. Carney
Table S1. RNA sequencing comparison data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4326a2d1d4bd7c3f8598e62becfbc5bf
https://doi.org/10.1158/1078-0432.22725165
https://doi.org/10.1158/1078-0432.22725165
Supplementary Figure 5: Low dose Rapamycin does not enhance efficacy of Ad-Flt3L + Ad-TK/GCV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae65f196573b4d49acab3dbc9ff3c6
https://doi.org/10.1158/1535-7163.22499931
https://doi.org/10.1158/1535-7163.22499931
Supplementary Figure 2: Effect of Rapamycin on GL26 and RG2 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fe23de9a26fbd37c766eeed090ca40
https://doi.org/10.1158/1535-7163.22499940.v1
https://doi.org/10.1158/1535-7163.22499940.v1
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cc1fd4a2f5e3986dfe5d2941ab43cb
https://doi.org/10.1158/1535-7163.22499928.v1
https://doi.org/10.1158/1535-7163.22499928.v1