Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Patrycja Gazinska"'
Autor:
Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Publikováno v:
Cancer Research. 83:P6-10
Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with oestrogen receptor (ER+) breast cancer (BC) where they are enriched in metastatic disease and are associated
Autor:
Patrycja Gazinska, Charlotte Milton, Jacopo Iacovacci, Joseph Ward, Richard Buus, Thanussuyah Alaguthurai, Rosalind Graham, Ayse Akarca, Esther Lips, Kalnisha Naidoo, Jelle Wesseling, Teresa Marafioti, Maggie Cheang, Cheryl Gillett, Yin Wu, Aadil Khan, Alan Melcher, Roberto Salgado, Mitch Dowsett, Andrew Tutt, Ioannis Roxanis, Syed Haider, Sheeba Irshad
Publikováno v:
Clinical Cancer Research. 28:4494-4508
Purpose: To identify potential immune targets in post-neoadjuvant chemotherapy (NAC)–resistant triple-negative breast cancer (TNBC) and ER+HER2– breast cancer disease. Experimental Design: Following pathology review, 153 patients were identified
Autor:
Gregory Verghese, Mengyuan Li, Fangfang Liu, Amit Lohan, Nikhil Cherian Kurian, Swati Meena, Patrycja Gazinska, Aekta Shah, Aasiyah Oozeer, Terry Chan, Mark Opdam, Sabine Linn, Cheryl Gillett, Elena Alberts, Thomas Hardiman, Samantha Jones, Selvam Thavaraj, J Louise Jones, Roberto Salgado, Sarah E Pinder, Swapnil Rane, Amit Sethi, Anita Grigoriadis
Publikováno v:
The Journal of Pathology.
Autor:
Shazia Irshad, Shamir Montazid, Daniel Hart, Sheila Bandyopadhyay, Brian Johnson, Sri Thrumurthy, Nan Gao, Mukesh Bansal, Philipp Altrock, Fabian Rost, Dustin Penn, Bettina Wernisch, Patrycja Gazinska, Piotr Ziółkowski, Bu'Hussain Hayee, Annamaria Tessitore, Walter Bodmer, James East, Nigel Bennett, Ian Tomlinson
The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent1, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity with increasing lifespan. Using cumulative BrdU labelling and a quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44c23da3b493211df4583495f654f06
https://doi.org/10.21203/rs.3.rs-2674841/v1
https://doi.org/10.21203/rs.3.rs-2674841/v1
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Lagging chromosomes in E-cadherin defective cell exposed to foretinib leading to failed cytokinesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46a503990fcd013cf24e9120ca5907e
https://doi.org/10.1158/2159-8290.22532777.v1
https://doi.org/10.1158/2159-8290.22532777.v1
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Figure S1. Frequency of genomic aberrations in the KCL TNBC cohort. Supplementary Figure S2. Conceptual diagrams of Scores of Chromosomal Instability Scarring (SCINS). Supplementary Figure S3. Extent and location of SCINS in TNBC. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094e1985f5e799065b529af5433df180
https://doi.org/10.1158/2159-8290.22531226.v1
https://doi.org/10.1158/2159-8290.22531226.v1
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Methods, Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f34678b3a6f52c27a52aa3119cc173
https://doi.org/10.1158/2159-8290.22531220
https://doi.org/10.1158/2159-8290.22531220
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a759d0659ac60046b51092f46f3457
https://doi.org/10.1158/2159-8290.c.6546827
https://doi.org/10.1158/2159-8290.c.6546827
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Lagging chromosomes followed by membrane oscillation in E-cadherin defective cell exposed to crizotinib leading to failed cytokinesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0689c434e70507463093d282c4705878
https://doi.org/10.1158/2159-8290.22532774
https://doi.org/10.1158/2159-8290.22532774
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Table S1. KCL TNBC and breast cell line cohort characteristics. Supplementary Table S2. Categories of genomic segment used as the basis for measuring SCINS. Supplementary Table S3. Genes expressed in a SAM of different SCINS clusters. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af647901e150db501520ef97984d3d5
https://doi.org/10.1158/2159-8290.22531217.v1
https://doi.org/10.1158/2159-8290.22531217.v1