Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Olena Barbash"'
Autor:
Weiyi Peng, Helai P. Mohammad, Patrick Hwu, Ryan G. Kruger, Olena Barbash, Linghua Wang, Mark T. Bedford, Qin Feng, Guangchun Han, Chunyu Xu, Leila J. Williams, Jenny Laraio, Satyajit Rajapurkar, Christian Sherk, Jiakai Hou, Yunfei Wang, Kimberly N. Smitheman, Shane O'Brien, Leilei Shi, Andrew Fedoriw
Supplementary Figure from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6dfa5fcb5450c54402a7d5bd6933d1
https://doi.org/10.1158/2326-6066.22544108
https://doi.org/10.1158/2326-6066.22544108
Autor:
Weiyi Peng, Helai P. Mohammad, Patrick Hwu, Ryan G. Kruger, Olena Barbash, Linghua Wang, Mark T. Bedford, Qin Feng, Guangchun Han, Chunyu Xu, Leila J. Williams, Jenny Laraio, Satyajit Rajapurkar, Christian Sherk, Jiakai Hou, Yunfei Wang, Kimberly N. Smitheman, Shane O'Brien, Leilei Shi, Andrew Fedoriw
Supplementary Table from Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23581ebfc323465362b79ff448ebda54
https://doi.org/10.1158/2326-6066.22544105
https://doi.org/10.1158/2326-6066.22544105
Autor:
Weiyi Peng, Helai P. Mohammad, Patrick Hwu, Ryan G. Kruger, Olena Barbash, Linghua Wang, Mark T. Bedford, Qin Feng, Guangchun Han, Chunyu Xu, Leila J. Williams, Jenny Laraio, Satyajit Rajapurkar, Christian Sherk, Jiakai Hou, Yunfei Wang, Kimberly N. Smitheman, Shane O'Brien, Leilei Shi, Andrew Fedoriw
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing arginine methylation on numerous protein substrates. Among them, type I PRMTs are responsible for generating asymmetric dimethylarginine. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6012567a496d1caf29d286b0c6d25ca5
https://doi.org/10.1158/2326-6066.c.6550529.v1
https://doi.org/10.1158/2326-6066.c.6550529.v1
Autor:
Michael Dickinson, Brandon E. Kremer, Arindam Dhar, Thierry Horner, Shawn W. Foley, Michael T. McCabe, Natalie O. Karpinich, Geraldine Ferron-Brady, Evi Bakirtzi, Olena Barbash, Anu Shilpa Krishnatry, Anastasia Wyce, Paolo Gallipoli, Ludovica Marando, Faisal Basheer, Regina García Delgado, Paul Yeh, Natalia Tovar, Maria-Victoria Mateos, Manali Kamdar, Jacob L. Glass, Gareth J. Morgan, Faith E. Davies, Daniel A. Pollyea, Dan T. Vogl, Aristeidis Chaidos, Adrian Alegre, Anastasios Karadimitris, Brian J.P. Huntly, Gautam Borthakur, Mark A. Dawson
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634832d4a4352226ded7a6d727fa619e
https://doi.org/10.1158/1078-0432.22490779
https://doi.org/10.1158/1078-0432.22490779
Autor:
Michael Dickinson, Brandon E. Kremer, Arindam Dhar, Thierry Horner, Shawn W. Foley, Michael T. McCabe, Natalie O. Karpinich, Geraldine Ferron-Brady, Evi Bakirtzi, Olena Barbash, Anu Shilpa Krishnatry, Anastasia Wyce, Paolo Gallipoli, Ludovica Marando, Faisal Basheer, Regina García Delgado, Paul Yeh, Natalia Tovar, Maria-Victoria Mateos, Manali Kamdar, Jacob L. Glass, Gareth J. Morgan, Faith E. Davies, Daniel A. Pollyea, Dan T. Vogl, Aristeidis Chaidos, Adrian Alegre, Anastasios Karadimitris, Brian J.P. Huntly, Gautam Borthakur, Mark A. Dawson
Purpose:Molibresib is a selective, small molecule inhibitor of the bromodomain and extra-terminal (BET) protein family. This was an open-label, two-part, Phase I/II study investigating molibresib monotherapy for the treatment of hematological maligna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b56a0a4932aa41df4a01b11e3217650
https://doi.org/10.1158/1078-0432.c.6533218.v1
https://doi.org/10.1158/1078-0432.c.6533218.v1
Autor:
Andrew Fedoriw, Leilei Shi, Shane O'Brien, Kimberly N. Smitheman, Yunfei Wang, Jiakai Hou, Christian Sherk, Satyajit Rajapurkar, Jenny Laraio, Leila J. Williams, Chunyu Xu, Guangchun Han, Qin Feng, Mark T. Bedford, Linghua Wang, Olena Barbash, Ryan G. Kruger, Patrick Hwu, Helai P. Mohammad, Weiyi Peng
Publikováno v:
Cancer Immunol Res
Protein arginine methyltransferases (PRMT) are a widely expressed class of enzymes responsible for catalyzing arginine methylation on numerous protein substrates. Among them, type I PRMTs are responsible for generating asymmetric dimethylarginine. By
Autor:
Mark D Stewart, Diana Merino Vega, Rebecca C Arend, Jonathan F Baden, Olena Barbash, Nike Beaubier, Grace Collins, Tim French, Negar Ghahramani, Patsy Hinson, Petar Jelinic, Matthew J Marton, Kimberly McGregor, Jerod Parsons, Lakshman Ramamurthy, Mark Sausen, Ethan S Sokol, Albrecht Stenzinger, Hillary Stires, Kirsten M Timms, Diana Turco, Iris Wang, J Andrew Williams, Elaine Wong-Ho, Jeff Allen
Publikováno v:
The Oncologist. 27:167-174
Background Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involv
Autor:
Mark A. Dawson, Gautam Borthakur, Brian J.P. Huntly, Anastasios Karadimitris, Adrian Alegre, Aristeidis Chaidos, Dan T. Vogl, Daniel A. Pollyea, Faith E. Davies, Gareth J. Morgan, Jacob L. Glass, Manali Kamdar, Maria-Victoria Mateos, Natalia Tovar, Paul Yeh, Regina García Delgado, Faisal Basheer, Ludovica Marando, Paolo Gallipoli, Anastasia Wyce, Anu Shilpa Krishnatry, Olena Barbash, Evi Bakirtzi, Geraldine Ferron-Brady, Natalie O. Karpinich, Michael T. McCabe, Shawn W. Foley, Thierry Horner, Arindam Dhar, Brandon E. Kremer, Michael Dickinson
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research.
Purpose:Molibresib is a selective, small molecule inhibitor of the bromodomain and extra-terminal (BET) protein family. This was an open-label, two-part, Phase I/II study investigating molibresib monotherapy for the treatment of hematological maligna
Autor:
Tatiana Erazo, Chiara M. Evans, Daniel Zakheim, Karen L. Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S. Leslie, Ari M. Melnick, Anas Younes, Michael G. Kharas
Publikováno v:
Nature communications. 13(1)
To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and drive
624 Targeting Type I arginine methyltransferases promotes T cell mediated antitumor immune responses
Autor:
Helai P. Mohammad, Weiyi Peng, Guangchun Han, Fedoriw Andrew Mark, Jenny Laraio, Patrick Hwu, Leila Williams, Olena Barbash, Christian S. Sherk, Qin Feng, Jiakai Hou, Chunyu Xu, Leilei Shi, Ryan G. Kruger, Yunfei Wang, Kimberly N. Smitheman, Satyajit R. Rajapurkar, Shane W. O'Brien, Linghua Wang, Mark Bedford
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAlthough immunotherapy produced dramatic clinical responses in a certain population of cancer patients, tumor cells can employ a variety of immunosuppressive measures to limit the immunotherapeutic efficacy. This highlights a great need to