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Autor:
Ahmad K. Haidar, Niels D. Kjeldsen, Nikolaj S. Troelsen, Viola Previtali, Kasper P. Lundquist, Thomas O. Larsen, Mads H. Clausen
Publikováno v:
Molecules
Molecules; Volume 27; Issue 2; Pages: 521
Molecules, Vol 27, Iss 521, p 521 (2022)
Haidar, A K, Kjeldsen, N D, Troelsen, N S, Previtali, V, Lundquist, K P, Larsen, T O & Clausen, M H 2022, ' A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B ', Molecules, vol. 27, no. 2, 521 . https://doi.org/10.3390/molecules27020521
Molecules; Volume 27; Issue 2; Pages: 521
Molecules, Vol 27, Iss 521, p 521 (2022)
Haidar, A K, Kjeldsen, N D, Troelsen, N S, Previtali, V, Lundquist, K P, Larsen, T O & Clausen, M H 2022, ' A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B ', Molecules, vol. 27, no. 2, 521 . https://doi.org/10.3390/molecules27020521
Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield). Thus,