Zobrazeno 1 - 10
of 12 165
pro vyhledávání: '"Medulloblastoma"'
Autor:
Konstantin Okonechnikov, Aniello Federico, Daniel Schrimpf, Philipp Sievers, Felix Sahm, Jan Koster, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Andrey Korshunov
Publikováno v:
Acta neuropathologica communications, 11(1):7. BioMed Central
Nowadays medulloblastoma (MB) tumors can be treated with risk-stratified approaches with up to 80% success rate. However, disease relapses occur in approximately 30% of patients and successful salvage treatment strategies at relapse remain scarce. Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0b5d5a6f8f716ae96e1bde288453a7
https://pure.amc.nl/en/publications/comparison-of-transcriptome-profiles-between-medulloblastoma-primary-and-recurrent-tumors-uncovers-novel-variance-effects-in-relapses(6e85d0db-b10d-44eb-866c-448c82ca306c).html
https://pure.amc.nl/en/publications/comparison-of-transcriptome-profiles-between-medulloblastoma-primary-and-recurrent-tumors-uncovers-novel-variance-effects-in-relapses(6e85d0db-b10d-44eb-866c-448c82ca306c).html
Publikováno v:
Journal of Neurosurgery: Pediatrics. 30:555-566
OBJECTIVE Medulloblastoma (MB) is the most common malignant pediatric brain tumor and accounts for approximately 20% of all pediatric CNS tumors. Current multimodal treatment is associated with a 70%–90% 5-year survival rate; however, the prognosis
Publikováno v:
Neurochirurgie. 68:601-607
Differential diagnosis between medulloblastoma (MB), ependymoma (EP) and astrocytoma (PA) is important due to differing medical treatment strategies and predicted survival. The aim of this study was to investigate non-invasive MRI-based radiomic anal
Autor:
Wei, Yang, Hong, Zhang, Yingjie, Cai, Xiaojiao, Peng, Hailang, Sun, Jiashu, Chen, Zesheng, Ying, Kaiyi, Zhu, Yun, Peng, Ming, Ge
Publikováno v:
Journal of Neurosurgery: Pediatrics. 30:567-577
OBJECTIVE In this study, the authors aimed to investigate the relationship between postoperative MRI features and cerebellar mutism syndrome. METHODS A retrospective cohort of patients who underwent tumor resection from July 2013 to March 2021 for mi
Autor:
Masih, Katherine
There have been significant successes in the treatment of childhood cancer, with the overall survival rate reaching nearly 80%. However, certain leukaemias and solid tumours, as well as metastatic and relapsed cancers, remain resistant to current the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7cf34bd4076aee95273e80189212e4f
Autor:
Andrey Korshunov, Konstantin Okonechnikov, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Koster, Philipp Sievers, Till Milde, Felix Sahm, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool
Publikováno v:
Acta neuropathologica, 145(6), 829-842. Springer Verlag
Medulloblastoma (MB), one of the most common malignant pediatric brain tumor, is a heterogenous disease comprised of four distinct molecular groups (WNT, SHH, Group 3, Group 4). Each of these groups can be further subdivided into second-generation MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30cebe6f275ecc3e8211b327221cd9f
https://pure.amc.nl/en/publications/transcriptome-analysis-stratifies-secondgeneration-nonwntnonshh-medulloblastoma-subgroups-into-clinically-tractable-subtypes(b543d191-09d8-4ea1-861b-3977f86fc9ca).html
https://pure.amc.nl/en/publications/transcriptome-analysis-stratifies-secondgeneration-nonwntnonshh-medulloblastoma-subgroups-into-clinically-tractable-subtypes(b543d191-09d8-4ea1-861b-3977f86fc9ca).html
Autor:
Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudière-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raúl A. Suárez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Bérubé, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, François Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fèvre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklós Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique López-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Iolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguía, Mario Pérezpeña, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Jüri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor
Publikováno v:
Nature, 609(7929), 1021-1028. Nature Publishing Group
Nature
Nature
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the
Autor:
Yasuzumi Matsui, Yohei Mineharu, Yuki Noguchi, Etsuko Yamamoto Hattori, Hirohito Kubota, Masahiro Hirata, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo
Publikováno v:
Biochemical and Biophysical Research Communications. 620:150-157
Malignancy of medulloblastoma depends on its molecular classification. Sonic Hedgehog (SHH)-type medulloblastoma with p53 mutation was recognized as one of the most aggressive types of tumors. We developed a novel drug, chlorambucil-conjugated PI-pol
Medulloblastoma accounts for 20% of all paediatric brain tumours as the second most frequent type. It arises from the embryonic neuroectodermal cells of the cerebellum, and itis characterized by decreased speech, mutism, cerebellar dysfunctions, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e4d6bb1cfe4d1e3313e57ad2077b83
https://hdl.handle.net/20.500.12511/10501
https://hdl.handle.net/20.500.12511/10501
Autor:
Abhinav Dey, Bing Yu, Kishore Kumar Jella, Anshu Malhotra, Jingbo Liu, Liangping Yuan, Tobey J. MacDonald, Matthew Schniederjan, Hongying Zhang, Leon F. McSwain
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 1009-1025 (2022)
Sonic hedgehog (Shh)-driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this study was to address the critical role of signal