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pro vyhledávání: '"Louis Hue"'
Publikováno v:
Biochemical Journal. 480:105-125
Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of A
Autor:
Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider
Publikováno v:
The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022)
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic gluco
Autor:
Luc Bertrand, Alice Marino, Audrey Ginion, Hermann Koepsell, Anne Bol, Anne Van Steenbergen, Laure Dumoutier, Laurent Bultot, Julien Cumps, Laura Ferté, Sylvain Battault, Christophe Beauloye, Louis Hue, Sandrine Horman
Publikováno v:
American journal of physiology. Heart and circulatory physiology, Vol. 320, no. 2, p. H838-H853 (2021)
Am J Physiol Heart Circ Physiol
Am J Physiol Heart Circ Physiol
Although sodium glucose cotransporter 1 (SGLT1) has been identified as one of the major SGLT isoforms expressed in the heart, its exact role remains elusive. Evidence using phlorizin, the most common inhibitor of SGLTs, has suggested its role in gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6875f081870d63e0b2f1b8957fe2f7
https://hdl.handle.net/2078.1/241325
https://hdl.handle.net/2078.1/241325
Autor:
Manuel Johanns, Louis Hue, Amina Houddane, Gaëtan Herinckx, Mark H. Rider, Christopher G. Proud, Didier Vertommen, S. Pyr dit Ruys
Publikováno v:
Cellular signalling, Vol. 36, p. 212-221 (2017)
Background Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a key regulator of protein synthesis in mammalian cells. It phosphorylates and inhibits eEF2, the translation factor necessary for peptide translocation during the elongation phase of
Autor:
Louis Hue, Nadège Zanou, Mark H. Rider, Samanta Kviklyte, Lars Löfgren, Catheline Plaideau, Philippe Gailly, Yu-Chiang Lai, Didier Vertommen, Mohammad Bohlooly-Y, Harriet Andersén, Stefan Hallén
Publikováno v:
Chemistry & Biology. 21(11):1497-1510
SummaryAMP-activated protein kinase (AMPK) plays a central role in regulating metabolism and energy homeostasis. It achieves its function by sensing fluctuations in the AMP:ATP ratio. AMP deaminase (AMPD) converts AMP into IMP, and the AMPD1 isoenzym
Autor:
Chantal Dessy, Gaetane Behets-Wydemans, Anne Van Steenbergen, Jean-Louis Vanoverschelde, Aurélie Timmermans, Magali Balteau, Sandrine Horman, Luc Bertrand, Christophe Beauloye, Patrick Gilon, Diego Castanares-Zapatero, Nicolas Tajeddine, Louis Hue
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H1120-H1133
Exposure of cardiomyocytes to high glucose concentrations (HG) stimulates reactive oxygen species (ROS) production by NADPH oxidase (NOX2). NOX2 activation is triggered by enhanced glucose transport through a sodium-glucose cotransporter (SGLT) but n
Autor:
Hermann Koepsell, Evangelos-Panagiotis Daskalopoulos, Gerard T. Berry, Magali Balteau, Sylvain Battault, Christophe Beauloye, Louis Hue, Jean-Louis Vanoverschelde, Sanda Despa, Audrey Ginion, Florin Despa, Jean-Luc Balligand, Sandrine Horman, Laura Ferté, Luc Bertrand, Patrick Gilon, Anne Van Steenbergen, Christophe de Meester de Ravenstein
Publikováno v:
Scientific Reports, Vol. 7, p. 41166 [1-14] (2017)
Scientific Reports
Scientific Reports
Hyperglycemia (HG) stimulates the production of reactive oxygen species in the heart through activation of NADPH oxidase 2 (NOX2). This production is independent of glucose metabolism but requires sodium/glucose cotransporters (SGLT). Seven SGLT isof
Autor:
Laurent Bultot, Luc Bertrand, Christophe Beauloye, Julien Auquier, Audrey Ginion, Jean-Louis Vanoverschelde, Isabelle Robillard Frayne, Caroline Daneault, Edith Renguet, Sandrine Horman, Christine Des Rosiers, Roselle Gélinas, Louis Hue
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 313(2)
High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose transport by activating an insulin-negative feedback loop driven by the mammalian target o
Autor:
Louis Hue, Ramon Bartrons, Didier Vertommen, Marie-Agnès Gueuning, Pierre Coulie, Manuel Johanns, Laura Novellasdemunt, Laurent Bultot, Mark H. Rider, Amina Houddane
Publikováno v:
Cellular signalling. 34
Proliferating cells depend on glycolysis mainly to supply precursors for macromolecular synthesis. Fructose 2,6-bisphosphate (Fru-2,6-P2) is the most potent positive allosteric effector of 6-phosphofructo-1-kinase (PFK-1), and hence of glycolysis. Mi
Autor:
Christophe Beauloye, S. Horman, Edith Renguet, Luc Bertrand, P. Morue, M. De Loof, Audrey Ginion, Louis Hue, Laurent Bultot
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 11:235
Introduction At rest, the heart favors fatty acids to produce its energy switching to glucose in response to insulin at postprandial state. Diabetic heart features metabolic adaptation defaults and is no longer able to switch, producing its energy ex