Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Klein-Szanto, Andres"'
Autor:
Francescone, Ralph, Vendramini-Costa, Débora Barbosa, Franco-Barraza, Janusz, Wagner, Jessica, Muir, Alexander, Lau, Allison N., Gabitova, Linara, Pazina, Tatiana, Gupta, Sapna, Luong, Tiffany, Shah, Neelima, Rollins, Dustin, Malik, Ruchi, Thapa, Roshan, Restifo, Diana, Zhou, Yan, Cai, Kathy Q., Hensley, Harvey H., Tan, Yinfei, Kruger, Warren D., Devarajan, Karthik, Balachandran, Siddharth, Klein-Szanto, Andres J., El-Deiry, Wafik S., Vander Heiden, Matthew G., Peri, Suraj, Campbell, Kerry S., Astsaturov, Igor, Cukierman, Edna
Summary Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year survival rate and lacks effective therapeutics. Therefore, it is of paramount importance to identify new targets. Using multi-plex data from patient tissue, three-dimensional co-cultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::348fba5889a8254a78fbf4ecc5b36c4c
Proprotein convertases (PCs) are serine proteases with an active role in the post-translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1cf5a7805ea1e456785ad21bc776f37f
https://europepmc.org/articles/PMC6166887/
https://europepmc.org/articles/PMC6166887/
Proprotein convertases (PC), a family of serine proteases, process cancer-related substrates such as growth factors, growth factor receptors, cell adhesion molecules, metalloproteinases, etc. HIF-1α is a major transcription factor involved in tumori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b69da249cb057b36fe3c9636fac908a1
https://europepmc.org/articles/PMC4101078/
https://europepmc.org/articles/PMC4101078/
Autor:
Natsuizaka, Mitsuteru, Kinugasa, Hideaki, Kagawa, Shingo, Whelan, Kelly A, Naganuma, Seiji, Subramanian, Harry, Chang, Sanders, Nakagawa, Kei J, Rustgi, Naryan L, Kita, Yoshiaki, Natsugoe, Shoji, Basu, Devraj, Gimotty, Phyllis A, Klein-Szanto, Andres J, Diehl, J Alan, Nakagawa, Hiroshi
Insulin-like growth factor binding protein 3 (IGFBP3), a hypoxia-inducible gene, regulates a variety of cellular processes including cell proliferation, senescence, apoptosis and epithelial-mesenchymal transition (EMT). IGFBP3 has been linked to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5eb19ff89b1be8dfc8e2bdef49c52060
https://europepmc.org/articles/PMC3902230/
https://europepmc.org/articles/PMC3902230/
Autor:
Fang, Carolyn Y., Egleston, Brian L., Ridge, John A., Lango, Miriam N., Bovbjerg, Dana H., Studts, Jamie L., Burtness, Barbara A., Einarson, Margret B., Klein-Szanto, Andres J. P.
Psychosocial functioning is associated with vascular endothelial growth factor (VEGF) in various patient populations. This study examined whether psychosocial functioning in patients with head and neck squamous cell carcinoma (HNSCC) is associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c44fa9b64100b0acf0681ec7422f89a
https://europepmc.org/articles/PMC4099415/
https://europepmc.org/articles/PMC4099415/
Autor:
Naganuma, Seiji, Whelan, Kelly A, Natsuizaka, Mitsuteru, Kagawa, Shingo, Kinugasa, Hideaki, Chang, Sanders, Subramanian, Harry, Rhoades, Ben, Ohashi, Shinya, Itoh, Hiroshi, Herlyn, Meenhard, Diehl, J Alan, Gimotty, Phyllis A, Klein-Szanto, Andres J, Nakagawa, Hiroshi
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of squamous cell carcinomas. Common genetic lesions in ESCC include p53 mutations and EGFR overexpression, both of which have been implicated in negative regulation of Notc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c6bfe53fc066930fa7d330808cfd4b1
https://europepmc.org/articles/PMC3410579/
https://europepmc.org/articles/PMC3410579/
Autor:
Makhlin, Igor, Zhang, Jiaru, Long, Christopher J., Devarajan, Karthik, Zhou, Yan, Klein-Szanto, Andres J., Huang, Min, Chernoff, Jonathan, Boorjian, Stephen A.
To investigate whether mammalian target of rapamycin (mTOR) inhibition by rapamycin is therapeutically efficacious in combination with cisplatin for bladder cancer.Using a panel of human urothelial carcinoma cell lines, we determined the effect of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc4f90dc95fda67d52ebcf97309fb7f7
https://europepmc.org/articles/PMC3116980/
https://europepmc.org/articles/PMC3116980/
Autor:
Mabuchi, Seiji, Kawase, Chiaki, Altomare, Deborah A., Morishige, Kenichirou, Hayashi, Masami, Sawada, Kenjiro, Ito, Kimihiko, Terai, Yoshito, Nishio, Yukihiro, Klein-Szanto, Andres J., Burger, Robert A., Ohmichi, Masahide, Testa, Joseph R., Kimura, Tadashi
This study examines the role of vascular endothelial growth factor (VEGF) as a therapeutic target in clear cell carcinoma (CCC) of the ovary, which has been regarded as a chemoresistant histologic subtype. Immunohistochemical analysis using tissue mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54e9029c0ed8ba83e6589b7f6c56d99f
https://europepmc.org/articles/PMC2941981/
https://europepmc.org/articles/PMC2941981/
Autor:
Bassi, Daniel E, Zhang, Jirong, Cenna, Jonathan, Litwin, Samuel, Cukierman, Edna, Klein-Szanto, Andres JP
PACE4 is a proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor progression. PACE4 overexpression significantly increased the susceptibility to carcinogenesis, leading to enhanced tumor cell pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab178b6cc64bc824aa8ff64ca0387249
https://europepmc.org/articles/PMC2907578/
https://europepmc.org/articles/PMC2907578/
Autor:
Balaburski, Gregor M., Dardes, Rita de Cássia de Maio [UNIFESP], Johnson, Michael, Haddad, Bassem, Zhu, Fang, Ross, Eric A., Sengupta, Surojeet, Klein-Szanto, Andres, Liu, Hong, Lee, Eun Sook, Kim, Helen, Jordan, V. Craig
Publikováno v:
Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
Department of Defense, Center of Excellence SPORE in Breast Cancer Genuardi's Fund FCCC Lynn Sage Breast Cancer Research Foundation Weg Fund of Fox Chase Cancer Center Cancer Center Support Grant (CCSG) We have previously demonstrated that prolonged