Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kerriann M. Casey"'
Autor:
Jessica M. Snyder, Kerriann M. Casey, Andrzej Galecki, David E. Harrison, Hashan Jayarathne, Navasuja Kumar, Francesca Macchiarini, Nadia Rosenthal, Marianna Sadagurski, Adam B. Salmon, Randy Strong, Richard A. Miller, Warren Ladiges
Publikováno v:
GeroScience. 45:385-397
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lif
Autor:
Ken Nakamura, Alex R. Dalal, Nobu Yokoyama, Albert J. Pedroza, Sho Kusadokoro, Olivia Mitchel, Casey Gilles, Bahar Masoudian, Matthew Leipzig, Kerriann M. Casey, William Hiesinger, Tetsuro Uchida, Michael P. Fischbein
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
BACKGROUND: To delineate the effects of integrin αv signaling in Marfan syndrome (MFS) and examine the potential efficacy of integrin αv blockade as a therapeutic strategy for MFS aneurysms. METHODS: Induced pluripotent stem cells were differentiat
Autor:
Yichi Su, Joel R. Walker, Mary P. Hall, Mark A. Klein, Xiang Wu, Lance P. Encell, Kerriann M. Casey, Lan Xiang Liu, Guosong Hong, Michael Z. Lin, Thomas A. Kirkland
Publikováno v:
Nature Chemical Biology.
Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical events in vivo and thus has become an indispensable technique in biomedical research. However, BLI in the central nervous system remains challenging because luci
Autor:
Binbin Chen, Aida Habtezion, Kerriann M. Casey, Bomi Lee, Nigel G. Kooreman, Xiaoming Ouyang, Yu Liu, Yang Zhou, Tzu-Tang Wei, Angela Zhang, Chun Liu, Joseph C. Wu, Edgar G. Engleman, Lin Wang, Jing Guo
Publikováno v:
Stem Cell Reports
Summary Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8+ T cel
Autor:
Mark R Krasnow, Jozeph L. Pendleton, Kerriann M. Casey, Caitlin J. Karanewsky, Megan A. Albertelli
Publikováno v:
Comparative Medicine. 71:256-266
The gray mouse lemur (Microcebus murinus, GML) is a nocturnal, arboreal, prosimian primate that is native to Madagascar. Captive breeding colonies of GMLs have been established primarily for noninvasive studies on questions related to circadian rhyth
Autor:
Kayvon Pedram, D. Judy Shon, Gabrielle S. Tender, Natalia R. Mantuano, Jason J. Northey, Kevin J. Metcalf, Simon P. Wisnovsky, Nicholas M. Riley, Giovanni C. Forcina, Stacy A. Malaker, Angel Kuo, Benson M. George, Caitlyn L. Miller, Kerriann M. Casey, José G. Vilches-Moure, Valerie M. Weaver, Heinz Laübli, Carolyn R. Bertozzi
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of substrates that can be selectively degraded, we designed degraders which are dependent on both peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eae7cde10003a5bd8961704a25b061e
https://doi.org/10.1101/2022.05.20.492748
https://doi.org/10.1101/2022.05.20.492748
Autor:
Adele Xu, Rut Molinuevo, Elisa Fazzari, Harrison Tom, Zijian Zhang, Julien Menendez, Kerriann M. Casey, Davide Ruggero, Lindsay Hinck, Jonathan K. Pritchard, Maria Barna
The formation of paralogs through gene duplication is a core evolutionary process. For paralogs that encode components of protein complexes such as the ribosome, a central question is whether they encode functionally distinct proteins, or whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d9dcdb3380a2645c902f24fd19c2187
https://doi.org/10.1101/2022.05.03.490441
https://doi.org/10.1101/2022.05.03.490441
Autor:
Sam W. Baker, Masahiro Maruyama, Kerriann M. Casey, Stuart B. Goodman, Felicity Gore, Jose G. Vilches-Moure, Yunzhi Peter Yang
Publikováno v:
Comp Med
Steroid-induced osteonecrosis of the femoral head (SONFH) is a condition documented in humans and animals exposed to chronic steroid administration. The rabbit has become a preferred animal model for investigating the pathogenesis and treatment of SO
Autor:
Yun Sheng Chen, Jianghong Rao, Weiping Zhu, Arvin M. Gouw, Jinghang Xie, Qihua Zhu, Zhi Yuan Wang, Leeann Hu, Liyang Cui, Elena A. Goun, Yao Tang, Ji Qi, Amato J. Giaccia, Zhou Gao, Dean W. Felsher, Shenghao Guo, Anne Le, Min Chen, Mingxi Fang, Kerriann M. Casey, Arkadiy A. Bazhin, Sanjiv S. Gambhir, Cissy Zhang, Nabeel Attarwala, Edward L. LaGory, Mark D. Pegram
Publikováno v:
Nature Biotechnology. 39:357-367
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are to
Autor:
Martina Tholen, John C. Widen, Kerriann M. Casey, Joshua J. Yim, Alwin Klaassen, Jonathan M. Sorger, Stephan Rogalla, Matthew Bogyo, Alexander L. Antaris
Publikováno v:
Nature biomedical engineering
Surgical resection of tumours requires precisely locating and defining the margins between lesions and normal tissue. However, this is made difficult by irregular margin borders. Although molecularly targeted optical contrast agents can be used to de