Zobrazeno 1 - 10
of 163
pro vyhledávání: '"John L. Magnani"'
Autor:
Carlton D. Dampier, Marilyn Jo Telen, Ted Wun, R. Clark Brown, Payal Desai, Fuad El Rassi, Beng Fuh, Julie Kanter, Yves Pastore, Jennifer Rothman, James G. Taylor, David Readett, Krupa M. Sivamurthy, Brinda Tammara, Li-Jung Tseng, Jay Nelson Lozier, Helen Thackray, John L. Magnani, Kathryn L. Hassell
Publikováno v:
Blood. 141:168-179
The efficacy and safety of rivipansel, a predominantly E-selectin antagonist, were studied in a phase 3, randomized, controlled trial for vaso-occlusive crisis (VOC) requiring hospitalization (RESET). A total of 345 subjects (204 adults and 141 child
Autor:
Yannan Jia, Weiguo Zhang, Mahesh Basyal, Kyung Hee Chang, Lauren Ostermann, Jared K. Burks, Charlie Ly, Hong Mu-Mosley, Qi Zhang, Xin Han, William E. Fogler, John L. Magnani, Arnaud Lesegretain, Anna A. Zal, Tomasz Zal, Michael Andreeff
Publikováno v:
Leukemia.
Publikováno v:
Blood Cancer Journal. 13
Autor:
Daniel D. Myers, William E. Fogler, John L. Magnani, Thomas W. Wakefield, Suman L. Sood, Angela E. Hawley, Robert E. Sigler, Laura Durham, Michael Holinstat, Veronica Dunivant, Garrett Reynolds, Kiley Crego, Reheman Adili, Patrick A Lester, Junjie Ning
Publikováno v:
Journal of Vascular Surgery: Venous and Lymphatic Disorders. 10:211-220
Background This study evaluated E-selectin inhibition with GMI-1271 (Uproleselan [GMI]) alone and in combination with the standard of care low-molecular-weight heparin (LMWH) to improve vein recanalization, decrease vein wall inflammation and protect
Autor:
Kyung Hee Chang, Weiguo Zhang, Muharrem Muftuoglu, Mahesh Basyal, Lauren Ostermann, Po Yee Mak, Yannan Jia, Wenjing Tao, William E. Fogler, John L. Magnani, Bing Z. Carter, Michael Andreeff
Publikováno v:
SSRN Electronic Journal.
Autor:
Garrett Reynolds, Zoe Zimmerman, Michael Holinstat, Reheman Adili, Patrick A Lester, Suman L. Sood, Daniel D. Myers, Robert E. Sigler, Kiley Crego, Angela E. Hawley, Laura Durham, Veronica Dunivant, William E. Fogler, Thomas W. Wakefield, John L. Magnani
Publikováno v:
Journal of Vascular Surgery: Venous and Lymphatic Disorders. 8:268-278
There is an inter-relationship between thrombosis and inflammation. Previously, we have shown the importance of P-selectin in thrombogenesis and thrombus resolution in many preclinical animal models. The role of E-selectin has been explored in rodent
Autor:
Daniel D. Myers, Martina V Hemmer, Angela E. Hawley, Suman L. Sood, John L. Magnani, Jordan K. Schaefer, Dana E. Angelini, Thomas W. Wakefield, Susan Blackburn, Helen M. Thackray, Sumana Devata
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 2, Pp 193-204 (2020)
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis
Background There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion molecules that augment thrombosis by activating immune cells to initiate the coagulation
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Neutrophils are essential to protect the host against invading pathogens but can promote disease progression in sickle cell disease (SCD) by becoming adherent to inflamed microvascular networks in peripheral tissue throughout the body. During the inf
Autor:
John L. Magnani, Ileana M. Cristea, Nandini Mondal, Corey Cheung, Sue Hwa Lin, Todd M. Greco, Hanqiu Zheng, Yibin Kang, Song Chang Lin, Yong Wei, Chiara Spadazzi, Robert Sackstein, Mark Esposito
Publikováno v:
Nature Cell Biology. 21:627-639
How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade. Previous studies have demonstrated the importance of the epithelial–me
Autor:
Helen M. Thackray, Eric J. Feldman, Brian A. Jonas, Daniel J. DeAngelo, Dale L. Bixby, Jane L. Liesveld, Paula Marlton, John L. Magnani, Anjali S. Advani, Michael O'Dwyer, Pamela S. Becker
Publikováno v:
Blood. 139(8)
Uproleselan (GMI-1271) is a novel E-selectin antagonist that disrupts cell survival pathways, enhances chemotherapy response, improves survival in mouse xenograft and syngeneic models, and decreases chemotherapy toxicity in vivo. A phase 1/2 study ev