Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Jessica L. Bell"'
Autor:
Mary C. Whitman, Nicole M. Gilette, Jessica L. Bell, Seoyoung A. Kim, Max Tischfield, Elizabeth C. Engle
Publikováno v:
Developmental Biology. 490:126-133
Heterozygous loss of function mutations in TWIST1 cause Saethre-Chotzen syndrome, which is characterized by craniosynostosis, facial asymmetry, ptosis, strabismus, and distinctive ear appearance. Individuals with syndromic craniosynostosis have high
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
To show that MRTF-A localization was dependent on F-actin dynamics, we stimulated SK-Mel-19 cells with 20% FBS to induce stress fiber formation which induced MRTF-A nuclear localization. We also treated SK-Mel-147 cells with latrunculin B which inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1117c9e2a1495f7253941a73c0d5452d
https://doi.org/10.1158/1535-7163.22508319
https://doi.org/10.1158/1535-7163.22508319
Autor:
Richard R. Neubig, Elizabeth R. Lawlor, Monique Verhaegen, Scott D. Larsen, Melanie A. Krook, Merlin Airik, Cheryl E. Rockwell, Jessica L. Bell, Susan M. Wade, Yajing Ji, Sean A. Misek, Erika M. Lisabeth, Kathryn M. Appleton, Andrew J. Haak
The Cancer Genome Atlas (TCGA) cutaneous melanoma dataset was stratified into quartiles based upon expression of indicated genes. Kaplan-Meier plots were generated from the highest (grey) and lowest (black) expressing quartiles. Survival curves were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412fad174ba69ff2635cf96a88d4e660
https://doi.org/10.1158/1535-7163.22508322.v1
https://doi.org/10.1158/1535-7163.22508322.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S1. PA2G4 is a MYCN transactivation target gene. A, Quantification of protein expression using anti-PA2G4 and anti-MYCN antibodies against whole cell protein lysates from BE(2)-C and Kelly cells, following MYCN siRNA knockdown fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60025d7d24b347241cbbcf5c562a70ea
https://doi.org/10.1158/0008-5472.22426183.v1
https://doi.org/10.1158/0008-5472.22426183.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S1. F, Confocal microscopy of SHEP Tet21N cells using anti-PA2G4 (red) and anti-MYCN (green) antibodies. G, Immunoblot analysis of cytoplasmic and nuclear fractions from BE(2)-C and Kelly human neuroblastoma cell lines with antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d30f1f6671b089f475263f614b3c030
https://doi.org/10.1158/0008-5472.22426180
https://doi.org/10.1158/0008-5472.22426180
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
MYCN is a major driver for the childhood cancer, neuroblastoma, however, there are no inhibitors of this target. Enhanced MYCN protein stability is a key component of MYCN oncogenesis and is maintained by multiple feedforward expression loops involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7722c088528eae6f7ee7e960f9d8b68
https://doi.org/10.1158/0008-5472.c.6512245
https://doi.org/10.1158/0008-5472.c.6512245
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S2. PA2G4 increases MYCN protein stability. A and B, Representative immunoblots from cycloheximide (CHX) chase assays measuring the half-life of MYCN protein after PA2G4 knockdown (A) or overexpression (B) in BE(2)-C and Kelly ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675af2bb1954e0b11b9f6bc816b84b2a
https://doi.org/10.1158/0008-5472.22426177.v1
https://doi.org/10.1158/0008-5472.22426177.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S4. Characterization of the PA2G4-MYCN protein-protein interface. A, BE(2)-C cells were transiently transfected with EV, wildtype PA2G4 or 6 different PA2G4 point mutants for 48 hours, then treated with 100 µg/µl Cycloheximide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64726cafd43ee43d489ae8588424b6d7
https://doi.org/10.1158/0008-5472.22426168.v1
https://doi.org/10.1158/0008-5472.22426168.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2b8ede76bf0ab8f04eadb6832eefa9
https://doi.org/10.1158/0008-5472.22426153.v1
https://doi.org/10.1158/0008-5472.22426153.v1
Autor:
Glenn M. Marshall, Belamy B. Cheung, Michael W. Parker, Giovanni Perini, Jamie I. Fletcher, Murray D. Norris, Michelle Haber, W. Clay Gustafson, Shizhen Zhu, Xiaoling Zhang, Tao Liu, Andrew J. Gifford, Matthias Fischer, Andre Oberthuer, Stefan Hüttelmaier, Larissa Doughty, Jessica L. Bell, Michael A. Gorman, Brendan W. Stevenson, Bryce Keenan, Chelsea Mayoh, Bing Liu, Joshua A. McCarroll, Jayne E. Murray, Giorgio Milazzo, Janith A. Seneviratne, Taylor Lim, Mika Herath, Olivia C. Ciampa, Daniel R. Carter, Hassina Massudi, Jessica K. Holien, Jessica Koach
Supplementary Figure S6. PA2G4 increases neuroblastoma tumorigenicity. A, Representative images of athymic nude mice inoculated with neuroblastoma (SH-EP) cells stably transfected with either EV control or a PA2G4 expression vector at 10 weeks post-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfa8995ffc3b6677c9a9bb42025eedf
https://doi.org/10.1158/0008-5472.22426159.v1
https://doi.org/10.1158/0008-5472.22426159.v1