Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Izu, Leighton T."'
Autor:
Wang, Huijia, Zhu, Guangxian, Izu, Leighton T, Chen-Izu, Ye, Ono, Naoaki, Altaf-Ul-Amin, MD, Kanaya, Shigehiko, Huang, Ming
Publikováno v:
Frontiers in Physiology. 14
Introduction: Given the direct association with malignant ventricular arrhythmias, cardiotoxicity is a major concern in drug design. In the past decades, computational models based on the quantitative structure–activity relationship have been propo
Autor:
Hegyi, Bence, Morotti, Stefano, Liu, Caroline, Ginsburg, Kenneth S, Bossuyt, Julie, Belardinelli, Luiz, Izu, Leighton T, Chen-Izu, Ye, Bányász, Tamás, Grandi, Eleonora, Bers, Donald M
Publikováno v:
Circulation. Arrhythmia and electrophysiology, vol 12, iss 3
BackgroundHeart failure (HF) is characterized by electrophysiological remodeling resulting in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic currents in HF promote action potential (AP) prolongation, increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::fa47185fcccd5205b02051d2e9f30ddd
https://escholarship.org/uc/item/7dw252cn
https://escholarship.org/uc/item/7dw252cn
Autor:
Sirish, Padmini, Ledford, Hannah A, Timofeyev, Valeriy, Thai, Phung N, Ren, Lu, Kim, Hyo Jeong, Park, Seojin, Lee, Jeong Han, Dai, Gu, Moshref, Maryam, Sihn, Choong-Ryoul, Chen, Wei Chun, Timofeyeva, Maria Valeryevna, Jian, Zhong, Shimkunas, Rafael, Izu, Leighton T, Chiamvimonvat, Nipavan, Chen-Izu, Ye, Yamoah, Ebenezer N, Zhang, Xiao-Dong
Publikováno v:
Circulation. Arrhythmia and electrophysiology, vol 10, iss 10
Intracellular pH (pHi) is critical to cardiac excitation and contraction; uncompensated changes in pHi impair cardiac function and trigger arrhythmia. Several ion transporters participate in cardiac pHi regulation. Our previous studies identified sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::90082f230f7ddcbd378bb470c7a0fbee
https://escholarship.org/uc/item/6m824672
https://escholarship.org/uc/item/6m824672
Autor:
Hegyi, Bence, Bossuyt, Julie, Griffiths, Leigh G, Shimkunas, Rafael, Coulibaly, Zana, Ginsburg, Kenneth S, Izu, Leighton T, Bányász, Tamás, Bers, Donald M, Chen-Izu, Ye
Publikováno v:
BIOPHYSICAL JOURNAL, vol 112, iss 3
Hegyi, B; Bossuyt, J; Griffiths, LG; Shimkunas, R; Coulibaly, Z; Ginsburg, KS; et al.(2017). Ionic Current Changes during Action Potentials in Porcine Post-MI Heart Failure Model. BIOPHYSICAL JOURNAL, 112(3), 402A-402A. doi: 10.1016/j.bpj.2016.11.2178. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/03k72445
Biophysical Journal, vol 112, iss 3
Hegyi, B; Bossuyt, J; Griffiths, LG; Shimkunas, R; Coulibaly, Z; Ginsburg, KS; et al.(2017). Ionic Current Changes during Action Potentials in Porcine Post-MI Heart Failure Model. BIOPHYSICAL JOURNAL, 112(3), 402A-402A. doi: 10.1016/j.bpj.2016.11.2178. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/03k72445
Biophysical Journal, vol 112, iss 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e6469533d9bda12d16643656a880de3e
https://escholarship.org/uc/item/03k72445
https://escholarship.org/uc/item/03k72445
Publikováno v:
Biophysical journal, vol 111, iss 6
In the heart, Na(+) is a key modulator of the action potential, Ca(2+) homeostasis, energetics, and contractility. Because Na(+) currents and cotransport fluxes depend on the Na(+) concentration in the submembrane region, it is necessary to accuratel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::aaf8e66b96f34cbb7ab9f97d5df7bf2e
https://escholarship.org/uc/item/7z67c6f3
https://escholarship.org/uc/item/7z67c6f3
Autor:
Abriel, Hugues, Izu, Leighton T, Marionneau, Celine, Sack, Jon T, Yarov-Yarovoy, Vladimir, Pitt, Geoffrey S, Shaw, Robin M, Chiamvimonvat, Nipavan, Cannell, Mark B, Catterall, William A, Chen-Izu, Ye, Aldrich, Richard W, Chazin, Walter J, Mohler, Peter J, Rajamani, Sridharan, Bers, Donald M, Maier, Lars S, Hund, Thomas J, Clancy, Colleen E, Grandi, Eleonora, Maltsev, Victor A, Sobie, Eric A, Rasmusson, Randall L, Belardinelli, Luiz, Deschenes, Isabelle
Publikováno v:
The Journal of physiology, vol 593, iss 6
This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc177fc297140c8b9d5834ab2dd348a
https://escholarship.org/uc/item/1n45t1wz
https://escholarship.org/uc/item/1n45t1wz
Autor:
Alexander, Amanda M., DeNardo, Erin K., Frazier III, Eric, McCauley, Michael, Rojina, Nicholas, Coulibaly, Zana, Peercy, Bradford E., Izu, Leighton T.
The heart's main function of pumping blood to the body is a complicated process separated into two major steps. Initially, the heart is relaxed and blood flows freely into the ventricles and atria from the veins, then the atria contracts and pumps mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba466f188e9bdc9143298724ece4303f