Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Dhanalakshmi Chinnasamy"'
Autor:
Steven A. Rosenberg, Nicholas P. Restifo, Richard A. Morgan, Ling Zhang, Sid P. Kerkar, Zhiya Yu, Dhanalakshmi Chinnasamy
Purpose: We investigated the feasibility of delivering the proinflammatory cytokine interleukin (IL)-12 into tumor using T cells genetically engineered to express a chimeric antigen receptor (CAR) against the VEGF receptor-2 (VEGFR-2).Experimental De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1591a415448bca7356f722b851d8b554
https://doi.org/10.1158/1078-0432.c.6520341
https://doi.org/10.1158/1078-0432.c.6520341
Autor:
Steven A. Rosenberg, Nicholas P. Restifo, Richard A. Morgan, Ling Zhang, Sid P. Kerkar, Zhiya Yu, Dhanalakshmi Chinnasamy
PDF file - 66K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f5af855d87dfadb10189a9a2995eeb
https://doi.org/10.1158/1078-0432.22444944.v1
https://doi.org/10.1158/1078-0432.22444944.v1
Autor:
Steven A. Rosenberg, Nicholas P. Restifo, Richard A. Morgan, Ling Zhang, Sid P. Kerkar, Zhiya Yu, Dhanalakshmi Chinnasamy
PDF file - 365K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2d428677987d698c8868e712d143b
https://doi.org/10.1158/1078-0432.22444947
https://doi.org/10.1158/1078-0432.22444947
Autor:
Steven A. Rosenberg, Nicholas P. Restifo, Richard A. Morgan, Zhiya Yu, Eric Tran, Dhanalakshmi Chinnasamy
Supplementary Methods - PDF file 91K, Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38586e2653d6ad87a1b9adaf646b3982
https://doi.org/10.1158/0008-5472.22397004
https://doi.org/10.1158/0008-5472.22397004
Autor:
Shelby N. Batchelor, Mark A. Nelson, Udaiyappan Janakiraman, Annaduri Anandhan, Lisa Boinon, Jie Yu, Aubin Moutal, Rajesh Khanna, Dhanalakshmi Chinnasamy
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryon
Autor:
Fang Yin, Sawa Ito, Francesco M. Marincola, Alexandros Spyridonidis, Ena Wang, Sid P. Kerkar, Dhanalakshmi Chinnasamy, Pawel Muranski, Gerrit Weber, J. Joseph Melenhorst, Nancy F. Hensel, Neima Hadi, Austin John Barrett
Publikováno v:
Immunology. 143:96-108
A growing body of evidence suggests that inflammatory cytokines have a dualistic role in immunity. In this study, we sought to determine the direct effects of interferon-γ (IFN-γ) on the differentiation and maturation of human peripheral blood mono
Autor:
Dhanalakshmi Chinnasamy, Eric Tran, Richard A. Morgan, Zhiya Yu, Steven A. Rosenberg, Nicholas P. Restifo
Publikováno v:
Cancer Research. 73:3371-3380
Most systemic cancer therapies target tumor cells directly, although there is increasing interest in targeting the tumor stroma that can comprise a substantial portion of the tumor mass. We report here a synergy between two T-cell therapies, one dire
Autor:
Zhiya Yu, Chyi-Chia Richard Lee, Eric Tran, Richard A. Morgan, Steven A. Rosenberg, Nicholas P. Restifo, Dhanalakshmi Chinnasamy
Publikováno v:
The Journal of Experimental Medicine
Transfer of FAP-reactive T cells into mice bearing a variety of subcutaneous tumors mediated limited antitumor effects and induced significant cachexia and lethal bone toxicities
Fibroblast activation protein (FAP) is a candidate universal targe
Fibroblast activation protein (FAP) is a candidate universal targe
Autor:
Richard A. Morgan, Sid P. Kerkar, Ling Zhang, Nicholas P. Restifo, Dhanalakshmi Chinnasamy, Steven A. Rosenberg, Zhiya Yu
Publikováno v:
Clinical Cancer Research. 18:1672-1683
Purpose: We investigated the feasibility of delivering the proinflammatory cytokine interleukin (IL)-12 into tumor using T cells genetically engineered to express a chimeric antigen receptor (CAR) against the VEGF receptor-2 (VEGFR-2). Experimental D
Autor:
Romina S. Goldszmid, Sid P. Kerkar, Robert Reger, Nicholas P. Restifo, Ena Wang, Dhanalakshmi Chinnasamy, Francesco M. Marincola, Zhiya Yu, Pawel Muranski, Anthony J. Leonardi, Giorgio Trinchieri, Steven A. Rosenberg, Richard A. Morgan
Publikováno v:
Journal of Clinical Investigation. 121:4746-4757
Solid tumors are complex masses with a local microenvironment, or stroma, that supports tumor growth and progression. Among the diverse tumor-supporting stromal cells is a heterogeneous population of myeloid-derived cells. These cells are alternative