Zobrazeno 61 - 70
of 86
pro vyhledávání: '"Dashyant Dhanak"'
Publisher Summary This chapter presents an overview of urotensin-II (U-II) receptor modulators. Human urotensin-II, a cyclic undecapeptide, was first isolated as a corresponding piscine analog in the 1960s from a vestigial organ in teleost fish where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967e5403c94bc08719e527dd10964382
https://doi.org/10.1016/s0065-7743(03)38012-1
https://doi.org/10.1016/s0065-7743(03)38012-1
Autor:
Victor K. Johnston, Carol Silverman, Ricardo Macarron, Arun C. Kaura, George M. Chan, Kevin J. Duffy, Alfred DelVecchio, Adam T. Gates, Hung-Yuan Cheng, Sanjay S. Khandekar, Derrick Maley, Baohua Gu, Lester L. Gutshall, Zaid Alnoah, Dashyant Dhanak, Antony N. Shaw, Robert T. Sarisky, Glenn A. Hofmann, Cathy Greenwood, David J. Casper, Richard M. Keenan, David L. Earnshaw, Michael R. Nonnemacher, Michael G. Darcy, Juili Lin-Goerke, Audrey Baker
Publikováno v:
The Journal of biological chemistry. 277(41)
The hepatitis C virus (HCV) NS5B protein encodes an RNA-dependent RNA polymerase (RdRp), the primary catalytic enzyme of the HCV replicase complex. We established a biochemical RNA synthesis assay, using purified recombinant NS5B lacking the C-termin
Autor:
Lisa T. Christmann, Kyle Elrod, Dashyant Dhanak, Richard M. Keenan, George Burton, Michael G. Darcy, Arun C. Kaura, Catherine E. Peishoff, Dinubhai H. Shah, John O. Link
Publikováno v:
ChemInform. 32
A versatile synthetic route to a novel series of bis-imidazolemethanes designed to inhibit the hCMV protease has been developed and a series of potential metal binding inhibitors has been identified. In selectivity assays, the compounds were highly s
Autor:
Catherine E. Peishoff, John O. Link, Arun C. Kaura, Dashyant Dhanak, Kyle Elrod, Michael G. Darcy, George Burton, Dinubhai H. Shah, Richard M. Keenan, Lisa T. Christmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(20)
A versatile synthetic route to a novel series of bis-imidazolemethanes designed to inhibit the hCMV protease has been developed and a series of potential metal binding inhibitors has been identified. In selectivity assays, the compounds were highly s
Autor:
Dashyant Dhanak
Publikováno v:
Cancer Research. 72:SY02-02
Enhance of Zeste Homolog 2 (EZH2) is the biochemical activity of the Polycomb Repressive Complex 2 (PRC2) that transfers a methyl group from the cofactor S-adenosyl methionine (SAM) to histone H3 on lysine 27 (H3K27), resulting in epigenetic silencin
Publikováno v:
Journal of medicinal chemistry. 36(10)
The synthesis and phosphodiesterase (PDE) inhibitory profile of a series of imidazopyridines, including sulmazole and isomazole, on separated PDE isoenzymes are described. The results show that both sulmazole and isomazole are weak inhibitors of PDE
Autor:
Jeffrey R. Jackson, Catherine A. Oleykowski, David Sutton, Ramona Plant, Hong Lu, Kurt R. Auger, Jamin Wang, Chiu-Mei Sung, Melody Diamond, Richard Wooster, Jeffrey D. Carson, Steven D. Knight, Richard R. Gontarek, Mary Ann Hardwicke, Christine M. Gardiner, Glenn S. Van Aller, Seth A. Gilbert, Peter J. Tummino, Lusong Luo, Dashyant Dhanak
Publikováno v:
Molecular Cancer Therapeutics. 8:C63-C63
The phosphoinositide 3-kinase (PI3K) pathway is among the most commonly activated pathways in human cancer. The biological role of PI3K in growth and survival of cancer cells and the prevalence of activating mutations in human cancers are well docume
Autor:
Christine M. Gardiner, Martha A. Sarpong, Kaushik Raha, Ken A. Newlander, Kurt R. Auger, Steven D. Knight, Cynthia A. Parrish, Lance Ridgers, Glenn S. Van Aller, Carla A. Donatelli, Amita M. Chaudhari, Peter J. Tummino, Schmidt Stanley J, Chiu-Mei Sung, Eric Garver, Jeffrey D. Carson, Michael G. Darcy, Lusong Luo, Dashyant Dhanak, Nicholas D. Adams, Joelle Lorraine Burgess, Patricia A. Elkins, Melody Diamond
Publikováno v:
Molecular Cancer Therapeutics. 8:C62-C62
Phosphoinositide 3-kinase (PI3K) is a critical regulator of cell growth and transformation and its signaling pathway is one of the most commonly mutated pathways in human cancer. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinas
Autor:
Jeffrey R. Jackson, David Sutton, Lusong Luo, Steven D. Knight, Kurt R. Auger, Robert A. Copeland, G. Van Aller, Peter J. Tummino, Melody Diamond, Dashyant Dhanak
Publikováno v:
European Journal of Cancer Supplements. 6:70