Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dai, James Y"'
Detecting and assessing statistical significance of differentially methylated regions (DMRs) is a fundamental task in methylome association studies. While the average differential methylation in different phenotype groups has been the inferential foc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c595d5b51f5abd582547c843e054c06a
http://arxiv.org/abs/2306.15032
http://arxiv.org/abs/2306.15032
Autor:
Dai, James Y., Chen, Heng, Wang, Xiaoyu, Sun, Wei, Huang, Ying, Grady, William M., Feng, Ziding
Cancer development is associated with aberrant DNA methylation, including increased stochastic variability. Statistical tests for discovering cancer methylation biomarkers have focused on changes in mean methylation. To improve the power of detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcd7eed508d6e8a877f6ba5eae9f0df
http://arxiv.org/abs/2306.14826
http://arxiv.org/abs/2306.14826
Heterogeneous treatment effects (HTE) based on patients' genetic or clinical factors are of significant interest to precision medicine. Simultaneously modeling HTE and corresponding main effects for randomized clinical trials with high-dimensional pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad4c278d79da583cf22d52768042c85
Autor:
Wang, Xiaoyu, Gharahkhani, Puya, Levine, David M., Fitzgerald, Rebecca C., Gockel, Ines, Corley, Douglas A., Risch, Harvey A., Bernstein, Leslie, Chow, Wong-Ho, Onstad, Lynn, Shaheen, Nicholas J., Lagergren, Jesper, Hardie, Laura J., Wu, Anna H., Pharoah, Paul D.P., Liu, Geoffrey, Anderson, Lesley A., Iyer, Prasad G., Gammon, Marilie D., Caldas, Carlos, Ye, Weimin, Barr, Hugh, Moayyedi, Paul, Harrison, Rebecca, Watson, R.G. Peter, Attwood, Stephen, Chegwidden, Laura, Love, Sharon B., MacDonald, David, deCaestecker, John, Prenen, Hans, Ott, Katja, Moebus, Susanne, Venerito, Marino, Lang, Hauke, Mayershofer, Rupert, Knapp, Michael, Veits, Lothar, Gerges, Christian, Weismüller, Josef, Reeh, Matthias, Nöthen, Markus, Izbicki, Jakob R., Manner, Hendrik, Neuhaus, Horst, Rösch, Thomas, Böhmer, Anne C., Hölscher, Arnulf H., Anders, Mario, Pech, Oliver, Schumacher, Brigitte, Schmidt, Claudia, Schmidt, Thomas, Noder, Tania, Lorenz, Dietmar, Vieth, Michael, May, Andrea, Hess, Timo, Kreuser, Nicole, Becker, Jessica, Ell, Christian, Tomlinson, Ian, Palles, Claire, Jankowski, Janusz A., Whiteman, David C., MacGregor, Stuart, Schumacher, Johannes, Vaughan, Thomas L., Buas, Matthew F., Dai, James Y., DeCaestecker, John, Weismueller, Josef, Noethen, Markus M., Roesch, Thomas, Boehmer, Anne C., Hoelscher, Arnulf H.
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention, 31, 1735-1745
Cancer epidemiology, biomarkers and prevention
Cancer Epidemiology, Biomarkers & Prevention, 31, 9, pp. 1735-1745
Cancer Epidemiol Biomarkers Prev
Cancer epidemiology, biomarkers and prevention
Cancer Epidemiology, Biomarkers & Prevention, 31, 9, pp. 1735-1745
Cancer Epidemiol Biomarkers Prev
Background: Over 20 susceptibility single-nucleotide polymorphisms (SNP) have been identified for esophageal adenocarcinoma (EAC) and its precursor, Barrett esophagus (BE), explaining a small portion of heritability. Methods: Using genetic data from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d3d842a36edd40a765388897f866d6
http://hdl.handle.net/2066/288033
http://hdl.handle.net/2066/288033
Autor:
Kapoor, Pooja Middha, Mavaddat, Nasim, Choudhury, Parichoy Pal, Wilcox, Amber N, Lindström, Sara, Behrens, Sabine, Michailidou, Kyriaki, Dennis, Joe, Bolla, Manjeet K, Wang, Qin, Jung, Audrey, Abu-Ful, Zomoroda, Ahearn, Thomas, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Freeman, Laura E Beane, Becher, Heiko, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bernstein, Leslie, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Cai, Qiuyin, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Carter, Brian D, Castelao, Jose E, Chanock, Stephen J, Chatterjee, Nilanjan, Chenevix-Trench, Georgia, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Dai, James Y, Earp, H Shelton, Ekici, Arif B, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Gao, Chi, Gapstur, Susan M, Gaudet, Mia M, Giles, Graham G, González-Neira, Anna, Guénel, Pascal, Haeberle, Lothar, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hatse, Sigrid, Heyworth, Jane, Holleczek, Bernd, Hoover, Robert N, Hopper, John L, Howell, Anthony, Hunter, David J, ABCTB Investigators, kConFab/AOCS Investigators, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W, Lambrechts, Diether, Le Marchand, Loic, Lee, Eunjung, Lejbkowicz, Flavio, Linet, Martha, Lissowska, Jolanta, Llaneza, Ana, MacInnis, Robert J, Martinez, Maria Elena, Maurer, Tabea, McLean, Catriona, Neuhausen, Susan L, Newman, William G, Norman, Aaron, O'Brien, Katie M, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Orr, Nick
Publikováno v:
Journal of the National Cancer Institute, vol 113, iss 3
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::11ef7a6cf5ca3b5f1a0d26842f8cb54c
https://escholarship.org/uc/item/93x1h7k2
https://escholarship.org/uc/item/93x1h7k2
Autor:
Kapoor, Pooja Middha, Mavaddat, Nasim, Choudhury, Parichoy Pal, Wilcox, Amber N, Lindström, Sara, Behrens, Sabine, Michailidou, Kyriaki, Dennis, Joe, Bolla, Manjeet K, Wang, Qin, Jung, Audrey, Abu-Ful, Zomoroda, Ahearn, Thomas, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Freeman, Laura E Beane, Becher, Heiko, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bernstein, Leslie, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brüning, Thomas, Cai, Qiuyin, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Carter, Brian D, Castelao, Jose E, Chanock, Stephen J, Chatterjee, Nilanjan, Chenevix-Trench, Georgia, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Dai, James Y, Earp, H Shelton, Ekici, Arif B, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Gao, Chi, Gapstur, Susan M, Gaudet, Mia M, Giles, Graham G, González-Neira, Anna, Guénel, Pascal, Haeberle, Lothar, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hatse, Sigrid, Heyworth, Jane, Holleczek, Bernd, Hoover, Robert N, Hopper, John L, Howell, Anthony, Hunter, David J, ABCTB Investigators, kConFab/AOCS Investigators, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Keeman, Renske, Kitahara, Cari M, Ko, Yon-Dschun, Koutros, Stella, Kurian, Allison W, Lambrechts, Diether, Le Marchand, Loic, Lee, Eunjung, Lejbkowicz, Flavio, Linet, Martha, Lissowska, Jolanta, Llaneza, Ana, MacInnis, Robert J, Martinez, Maria Elena, Maurer, Tabea, McLean, Catriona, Neuhausen, Susan L, Newman, William G, Norman, Aaron, O'Brien, Katie M, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Orr, Nick, Perou, Charles M, Pita, Guillermo, Polley, Eric C, Prentice, Ross L, Rennert, Gad, Rennert, Hedy S, Ruddy, Kathryn J, Sandler, Dale P, Saunders, Christobel, Schoemaker, Minouk J, Schöttker, Ben, Schumacher, Fredrick, Scott, Christopher, Scott, Rodney J, Shu, Xiao-Ou, Smeets, Ann, Southey, Melissa C, Spinelli, John J, Stone, Jennifer, Swerdlow, Anthony J, Tamimi, Rulla M, Taylor, Jack A, Troester, Melissa A, Vachon, Celine M, van Veen, Elke M, Wang, Xiaoliang, Weinberg, Clarice R, Weltens, Caroline, Willett, Walter, Winham, Stacey J, Wolk, Alicja, Yang, Xiaohong R, Zheng, Wei, Ziogas, Argyrios, Dunning, Alison M, Pharoah, Paul DP, Schmidt, Marjanka K, Kraft, Peter, Easton, Douglas F, Milne, Roger L, García-Closas, Montserrat, Chang-Claude, Jenny
We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::1dbfc9f7409c8357eb6cd2fb54693c1e
https://www.repository.cam.ac.uk/handle/1810/304345
https://www.repository.cam.ac.uk/handle/1810/304345
Autor:
PRACTICAL Consortium, Karlsson, Questa, Brook, Mark N, Dadaev, Tokhir, Wakerell, Sarah, Saunders, Edward J, Muir, Kenneth, Neal, David E, Giles, Graham G, MacInnis, Robert J, Thibodeau, Stephen N, McDonnell, Shannon K, Cannon-Albright, Lisa, Teixeira, Manuel R, Paulo, Paula, Cardoso, Marta, Huff, Chad, Li, Donghui, Yao, Yu, Scheet, Paul, Permuth, Jennifer B, Stanford, Janet L, Dai, James Y, Ostrander, Elaine A, Cussenot, Olivier, Cancel-Tassin, Géraldine, Hoegel, Josef, Herkommer, Kathleen, Schleutker, Johanna, Tammela, Teuvo L J, Rathinakannan, Venkat, Sipeky, Csilla, Wiklund, Fredrik, Grönberg, Henrik, Aly, Markus, Isaacs, William B, Dickinson, Jo L, FitzGerald, Liesel M, Chua, Melvin L K, Nguyen-Dumont, Tu, Schaid, Daniel J, Southey, Melissa C, Eeles, Rosalind A, Kote-Jarai, Zsofia
Publikováno v:
European Urology Oncology
BACKGROUND: Germline ATM mutations are suggested to contribute to predisposition to prostate cancer (PrCa). Previous studies have had inadequate power to estimate variant effect sizes. OBJECTIVE: To precisely estimate the contribution of germline ATM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1152018a2b3bcc0b7a2db43b99fa83e
https://trepo.tuni.fi/handle/10024/133783
https://trepo.tuni.fi/handle/10024/133783
Autor:
O'Donnell, Christopher J., Lettre, Guillaume, Rich, Stephen S., Wilson, James G., Lange, Leslie A., Tracy, Russell P., Wurfel, Mark M., Ganesh, Santhi K., Tang, Hua, Jiao, Shuo, Smith, Nicholas L., Dai, James Y., Kooperberg, Charles, Jackson, Rebecca D., Nickerson, Deborah A., Auer, Paul L., Carlson, Christopher S., Johnsen, Jill M., Reiner, Alexander P., Logsdon, Benjamin A.
Recently, many statistical methods have been proposed to test for associations between rare genetic variants and complex traits. Most of these methods test for association by aggregating genetic variations within a predefined region, such as a gene.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e833d3935dd9685eb83ce35113f01c5
Genome-wide association studies, in which as many as a million single nucleotide polymorphisms (SNP) are measured on several thousand samples, are quickly becoming a common type of study for identifying genetic factors associated with many phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c33a85e35d87858aea2f34c2593474
Autor:
Mcgowan, Ian, Hoesley, Craig, Cranston, Ross D., Andrew, Philip, Dai, James Y., Janocko, Laura, Carballo-Dieguez, Alex, Ayudhya, Ratiya Kunjara Na, Piper, Jeanna, Hladik, Florian, Mayer, Ken
Objective Rectal microbicides are needed to reduce the risk of HIV acquisition associated with unprotected receptive anal intercourse. The MTN-007 study was designed to assess the safety (general and mucosal), adherence, and acceptability of a new re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6895ea639ce61a95058fee812aa9eb9