Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christoph W. Grathwol"'
Autor:
João Macara, Catarina Caldeira, José Cunha, Jaime A. S. Coelho, Maria J. S. A. Silva, Konrad Krämer, Christoph W. Grathwol, Stefan Bräse, M. Manuel B. Marques
Publikováno v:
Organicbiomolecular chemistry.
A methodology for the synthesis of sulfonyl hydrazides mediated by hypervalent iodine is described. Taking advantage of the umpolung properties of hypervalent iodine reagents, the polarity of sodium sulfinate salts is reversed, and a key intermediate
Autor:
Sascha Grobe, Thomas Bayer, Emil Hamnevik, Sven Koban, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Christoph W. Grathwol, Christoffel P. S. Badenhorst, Andreas Link, Henrike Brundiek
Publikováno v:
Angewandte Chemie (International Ed. in English)
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo‐ and regioselective 7β‐hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydro
Autor:
Christoffel P. S. Badenhorst, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Sven Koban, Thomas Bayer, Henrike Brundiek, Christoph W. Grathwol, Sascha Grobe, Emil Hamnevik, Andreas Link
Publikováno v:
Angewandte Chemie. 133:764-768
Autor:
Christoph W. Grathwol, Klaus Weisz, Yoanes Maria Vianney, Andreas Link, Qingyun Tang, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
ChemCatChem. 12:3721-3727
Methylation of free hydroxyl groups is an important modification for flavonoids. It not only greatly increases absorption and oral bioavailability of flavonoids, but also brings new biological activities. Flavonoid methylation is usually achieved by
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 12, Pp 1828-1832 (2019)
Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 12, Pp 1828-1832 (2019)
A benzoquinone compound was unintentionally synthesized by photocyclization and subsequent oxidation in air while attempting to transform the E isomer of a nicotinamide derivative to its Z isomer. The chemical and molecular structures of the pr
Autor:
Christian Bock, Andreas Link, Robert K. Hofstetter, Werner Siegmund, Felix Potlitz, Abdrrahman Shemsu Surur, Georg M. Fassauer, Tobias Oergel, Christoph W. Grathwol, Mahmoud Hasan, Steven Behnisch
Publikováno v:
Journal of Chromatography A. 1603:338-347
Supercritical fluid chromatography (SFC) holds the potential to become an orthogonal method to HPLC/UHPLC in xenobiotic metabolism studies, due to its outstanding capacity to simultaneously separate highly similar (as HPLC) and physicochemically diff
Autor:
Robert K. Hofstetter, Andreas Link, Nathalie Wössner, Manfred Jung, Anja Bodtke, Adam C. Smith, Christoph W. Grathwol, Enrico Tapavicza, Sören Swyter
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2170-2183 (2019)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound
Autor:
Qingyun Tang, Christoph W. Grathwol, Shuke Wu, Christoffel P. S. Badenhorst, Andreas Link, Aşkın S. Aslan-Üzel, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently sh
Autor:
Steven Behnisch-Cornwell, Christoph W. Grathwol, Lukas Schulig, Anika Voigt, Daniel Baecker, Andreas Link, Patrick J. Bednarski
Publikováno v:
Cancers, Vol 14, Iss 187, p 187 (2022)
Cancers; Volume 14; Issue 1; Pages: 187
Cancers
Cancers; Volume 14; Issue 1; Pages: 187
Cancers
Simple Summary Protein expression profiles of 10 HDAC/Sirtuin isoenzymes in two panels of human cancer cell lines were compared with each other and with the potencies of various anticancer drugs by Pearson and Spearman correlation analysis to identif
Autor:
Lukas Schulig, Andreas Link, Nathalie Wössner, Steven Behnisch‐Cornwell, Christoph W. Grathwol, Manfred Jung, Oliver Einsle, Lin Zhang
Publikováno v:
Chemmedchem
Because isoenzymes of the experimentally and therapeutically extremely relevant sirtuin family show high similarity, addressing the unique selectivity pocket of sirtuin 2 is a promising strategy towards selective inhibitors. An unrelated approach tow