Zobrazeno 1 - 10
of 363
pro vyhledávání: '"B. Glick"'
Autor:
Fiona E. Chalmers, Saie Mogre, Bipin Rimal, Jeongin Son, Andrew D. Patterson, Douglas B. Stairs, Adam B. Glick
Publikováno v:
Developmental Biology. 492:59-70
The IRE1α-XBP1s signaling branch of the unfolded protein response is a well-characterized survival pathway that allows cells to adapt to and resolve endoplasmic reticulum stress. Recent data has broadened our understanding of IRE1α-XBP1s signaling
Autor:
Nick A. Alden, Julien H. Arrizabalaga, Yiming Liu, Shantu Amin, Krishne Gowda, Shun Yao, Marco Archetti, Adam B. Glick, Daniel J. Hayes
Publikováno v:
Langmuir. 38:9833-9843
In this study, we utilized selectively modified, biodegradable polymer-based polyplexes to deliver custom, exogenous miR-148b mimics to induce apoptosis in human lung cancer (A549) cells. The gene regulatory effects of the payload miRNA mimics (miR-1
TGFβ has both tumor suppressive and oncogenic roles in cancer development. We previously showed that SB431542 (SB), a small molecule inhibitor of the TGFβ type I receptor (ALK5) kinase, suppressed benign epidermal tumor formation but enhanced malig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3407cb73b01f1f4f547b91efda2d6960
https://doi.org/10.1158/1541-7786.c.6541939.v1
https://doi.org/10.1158/1541-7786.c.6541939.v1
Supplementary Figure 1 from Pharmacologic Inhibition of ALK5 Causes Selective Induction of Terminal Differentiation in Mouse Keratinocytes Expressing Oncogenic HRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415391815be69177544156606229ceb9
https://doi.org/10.1158/1541-7786.22518481
https://doi.org/10.1158/1541-7786.22518481
Autor:
Adam B. Glick, Kyle Breech, Carrie J. Oakes, Andrew J. Gunderson, Jacob T. Bailey, Michael A. Podolsky
Supplementary Table 1: Primers used for genotyping and qRT-PCR. Supplementary Figure 1: Establishment of murine models of targeted H-RasV12G to basal and suprabasal layers of the epidermis. Supplementary Figure 2: Leukocyte infiltration into K14Ras a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21ffaacb3e4cd4bb933fd31e707424b
https://doi.org/10.1158/2326-6066.22538150
https://doi.org/10.1158/2326-6066.22538150
Autor:
Adam B. Glick, Kyle Breech, Carrie J. Oakes, Andrew J. Gunderson, Jacob T. Bailey, Michael A. Podolsky
Heterogeneity in tumor immune responses is a poorly understood yet critical parameter for successful immunotherapy. In two doxycycline-inducible models where oncogenic H-RasG12V is targeted either to the epidermal basal/stem cell layer with a Keratin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d42e940da77d861c6f777d7ec523a6
https://doi.org/10.1158/2326-6066.c.6548690.v1
https://doi.org/10.1158/2326-6066.c.6548690.v1
MOV file - 2.3MB, Effects of mTor Inhibitor rapamycin on Ras-driven basal MEC overgrowth. Representative video depicting an organoid prepared from a Dox-naive basalRas/GFP (K5-rtTA/TGFP/TRAS) mouse cultured in the presence of both Dox and rapamycin i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d9a443fa1f9d9afa1a15ea458390be
https://doi.org/10.1158/0008-5472.22394366.v1
https://doi.org/10.1158/0008-5472.22394366.v1
The mammary ducts of humans and mice are comprised of two main mammary epithelial cell (MEC) subtypes: a surrounding layer of basal MECs and an inner layer of luminal MECs. Breast cancer subtypes show divergent clinical behavior that may reflect prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a61139985d10a4fb1ed71057f86ecec9
https://doi.org/10.1158/0008-5472.c.6504017.v1
https://doi.org/10.1158/0008-5472.c.6504017.v1
MOV file - 2.1MB, ive cell imaging of H-RASG12V-driven basal MEC overgrowth. Representative video depicting an organoid prepared from a Dox-naive basalRas/GFP (K5-rtTA/TGFP/TRAS) mouse cultured in 3D with Dox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c21e141d8ff4b109b65c4da79e4e4f
https://doi.org/10.1158/0008-5472.22394387
https://doi.org/10.1158/0008-5472.22394387
MOV file - 1.6MB, Effects of Pi3k Inhibitor LY294002 on Ras-driven luminal MEC overgrowth. Representative video depicting an organoid prepared from a Dox-naive luminalRas/GFP (MMTV-rtTA/TGFP/TRAS) mouse cultured in the presence of both Dox and LY2940
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401f1cc30ebfaa9d45ed26796a6a6bec
https://doi.org/10.1158/0008-5472.22394369.v1
https://doi.org/10.1158/0008-5472.22394369.v1