Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ashley L. Cooney"'
Autor:
Tayyab Rehman, Philip H. Karp, Andrew L. Thurman, Steven E. Mather, Akansha Jain, Ashley L. Cooney, Patrick L. Sinn, Alejandro A. Pezzulo, Michael E. Duffey, Michael J. Welsh
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:491-502
In cystic fibrosis (CF), reduced HCOsub3/subsup-/supsecretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHsubASL/sub) in CF may help identify novel targets and faci
Autor:
Ashley L. Cooney, Paul B. McCray, Soumba Traore, Patrick L. Sinn, Sateesh Krishnamurthy, Christian M Brommel, Katarina Kulhankova, Gregory A. Newby, David R. Liu
Publikováno v:
Nucleic Acids Research
Mutations in the CFTR gene that lead to premature stop codons or splicing defects cause cystic fibrosis (CF) and are not amenable to treatment by small-molecule modulators. Here, we investigate the use of adenine base editor (ABE) ribonucleoproteins
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss, Pp 293-301 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function? We used a lentiviral vect
Autor:
Qian Dong, Ashley L. Cooney, Stefano Rivella, Paul B. McCray, Christoph O. Randak, Patrick L. Sinn, Laura I. Marquez Loza
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 94-106 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Despite significant advances in cystic fibrosis (CF) treatments, a one-time treatment for this life-shortening disease remains elusive. Stable complementation of the disease-causing mutation with a normal copy of the CF transmembrane conductance regu
Publikováno v:
Hum Gene Ther
The list of successful gene therapy trials using adeno-associated virus (AAV)-based vectors continues to grow and includes a wide range of monogenic diseases. Replication incompetent AAV genomes typically remain episomal and expression dilutes as cel
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2022)
Frontiers in Genome Editing
Frontiers in Genome Editing
Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in premature infants, severe RDS in term and late preterm infants s
Autor:
Patrick L. Sinn, Ashley L. Cooney
Publikováno v:
Biotechniques
Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose. However, large animal models are often more relevant for the transiti
Autor:
Patrick L. Sinn, David A. Stoltz, Brajesh K. Singh, Joseph Zabner, Viral Shah, Ian M. Thornell, Ashley L. Cooney, Paul B. McCray
Publikováno v:
Am J Respir Cell Mol Biol
Cystic fibrosis is an autosomal-recessive disease that is caused by a mutant CFTR (cystic fibrosis transmembrane conductance regulator) gene and is characterized by chronic bacterial lung infections and inflammation. Complementation with functional C
Autor:
Nicholas J. Lennemann, Robert A. Davey, Wendy Maury, Jacob A. Dillard, Natalie Ruggio, Grace A. Schaack, Ashley L. Cooney
Publikováno v:
J Virol
Sudan virus (SUDV) is one of five filoviruses that compose the genus Ebolavirus that has been responsible for episodic outbreaks in Central Africa. While the SUDV glycoprotein (GP) structure has been solved, GP residues that affect SUDV entry have no
Autor:
Andrew L Thurman, Camilla E Hippee, Brajesh K. Singh, Alejandro A. Pezzulo, Roberto Cattaneo, Patrick L. Sinn, Ashley L. Cooney
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009458 (2021)
PLoS Pathogens, Vol 17, Iss 8, p e1009458 (2021)
Measles virus (MeV) is the most contagious human virus. Unlike most respiratory viruses, MeV does not directly infect epithelial cells upon entry in a new host. MeV traverses the epithelium within immune cells that carry it to lymphatic organs where