Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andrew Dervan"'
Autor:
Brian S. White, Mehmet Kemal Samur, Alexander V. Ratushny, Michael Mason, Gareth J. Morgan, Justin Guinney, Yi Cui, Pieter Sonneveld, Bailiang Li, Carolina Schinke, Fadi Towfic, Samuel A. Danziger, Hervé Avet-Loiseau, Matthew Trotter, Elias Chaibub Neto, Hongyue Y Dai, Valeriy V. Lyzogubov, Christine Eng, Jonathan Göke, Anjan Thakurta, Hongjie Chen, Andrew Dervan, William S. Dalton, Daniel Auclair, Douglas Bassett, Nikhil C. Munshi, Kenneth H. Shain, Fred K. Gruber, Boris Hayete, Brian A Walker, Aditya Pratapa, Frank Schmitz, Hartmut Goldschmidt, Thomas Yu, Dirk Hose, Erin Flynt, Kamlesh Bisht, Maria Ortiz, Yuanfang Guan, Konstantinos Mavrommatis, Dan Rozelle
Publikováno v:
Leukemia 34, 1866–1874 (2020)
Leukemia
Leukemia
While the past decade has seen meaningful improvements in clinical outcomes for multiple myeloma patients, a subset of patients do not benefit from current therapeutics for unclear reasons. Many gene expression-based models of risk have been develope
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Alexander V. Ratushny, Robert M. Hershberg, Serdar Turkarslan, Nitin S. Baliga, Matthew William Burnell Trotter, Douglas Bassett, Adrián López García de Lomana, David J. Reiss, Samuel A. Danziger, Matthew A. Wall, Michael Mason, Andrew Dervan, Wei-Ju Wu
Publikováno v:
NPJ Precision Oncology
npj Precision Oncology, Vol 5, Iss 1, Pp 1-15 (2021)
npj Precision Oncology, Vol 5, Iss 1, Pp 1-15 (2021)
Despite recent advancements in the treatment of multiple myeloma (MM), nearly all patients ultimately relapse and many become refractory to their previous therapies. Although many therapies exist with diverse mechanisms of action, it is not yet clear
Autor:
Mark McConnell, Samuel A. Danziger, Boris Aguilar, David J. Reiss, Matthew Trotter, Alexander V. Ratushny, Andrew Dervan, Robert M. Hershberg, Ilya Shmulevich, Douglas Bassett, David L Gibbs
Publikováno v:
GigaScience
Background Mechanistic models, when combined with pertinent data, can improve our knowledge regarding important molecular and cellular mechanisms found in cancer. These models make the prediction of tissue-level response to drug treatment possible, w
Autor:
Andrew Dervan, Matthew Trotter, Christopher Mark Hill, Brian Fox, Hamid Bolouri, Alexander V. Ratushny, Anne-Renee van der Vuurst de Vries, Joshua Beilke, Pallavur Sivakumar, Paul Shannon, Rebecca Johnson, Mary Young, Lu Huang, Douglas Bassett, C.C. Santini
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Failure to clear antigens causes CD8+ T cells to become increasingly hypo-functional, a state known as exhaustion. We combined manually extracted information from published literature with gene expression data from diverse model systems to infer a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c710102aeb2ce4874d47ec577d38fe37
Autor:
Mehmet Kemal Samur, Fadi Towfic, Hartmut Goldschmidt, Justin Guinney, Daniel Auclair, Yi Cui, Brian A Walker, Bailiang Li, Nikhil C. Munshi, Andrew Dervan, Kenneth H. Shain, Hongyue Dai, Fred K. Gruber, Boris Hayete, Jonathan Göke, Thomas Yu, Pieter Sonneveld, Maria Ortiz, Douglas Bassett, William S. Dalton, Dirk Hose, Gareth J. Morgan, Erin Flynt, Hervé Avet-Loiseau, Anjan Thakurta, Michael Mason, Christine Eng, Carolina Schinke, Matthew Trotter, Brian S. White
Publikováno v:
Blood. 134:4370-4370
Multiple myeloma (MM) is a hematological malignancy of terminally differentiated plasma cells residing within the bone marrow with 25,000-30,000 patients diagnosed in the United States each year. The disease's clinical course depends on a complex int
Autor:
Joanne Armstrong, Katrina Armstrong, Samuel J. Aronson, Adam C. Berger, Zhaohui Chen, Andrew Dervan, Katherine Donigan, Edward S. Dove, Eric Faulkner, Benjamin French, Elyse Galloway, Geoffrey S. Ginsburg, Elizabeth A. Grice, Ken J. Hampel, N. Katsanis, S.H. Katsanis, Stephen E. Kimmel, Bartha M. Knoppers, Graeme T. Laurie, Liis Leitsalu, Debra G.B. Leonard, Elizabeth Mansfield, Daniel R. Masys, Robert McDonough, Jacquelyn S. Meisel, Andres Metspalu, Michael F. Murray, Lori A. Orlando, Philip R.O. Payne, Alanna Kulchak Rahm, Arti K. Rai, Timothy E. Reddy, Shelby D. Reed, Laura Lyman Rodriguez, R. Ryanne Wu, Jay Shendure, Nikoletta Sidiropoulos, Steven Tjoe, Jennifer E. Van Eyk, David L. Veenstra, Deepak Voora, Robyn Ward, Huntington F. Willard, Marc S. Williams
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c915262281053af8245e16053de27b5f
https://doi.org/10.1016/b978-0-12-800681-8.00029-3
https://doi.org/10.1016/b978-0-12-800681-8.00029-3
Autor:
Alexander V. Ratushny, Rob Hershberg, Mary Young, Faith E. Davies, Antje Hoering, Frits van Rhee, Adam Rosenthal, Gareth J. Morgan, Matthew Trotter, Bart Barlogie, Brian A Walker, Maurizio Zangari, Mark McConnell, Brian Fox, Katie Newhall, Jake Gockley, Andrew Dervan, Nathan Petty, Michael A Bauer, Wilbert B. Copeland, Samuel A. Danziger, Cody Ashby, Alison Fitch, David J. Reiss, Frank Schmitz, Phil Farmer
Publikováno v:
Blood. 132:1882-1882
Introduction The multiple myeloma (MM) tumor microenvironment (TME) strongly influences patient outcomes as evidenced by the success of immunomodulatory therapies. To develop precision immunotherapeutic approaches, it is essential to identify and enu
Autor:
John G. Gribben, Andrew Dervan, Teri Foy, Alison Fitch, Katie Newhall, Elizabeth Whalen, Mary H. Young, Mark Tometsko, Jamie Cavenagh, Ethan G. Thompson, Brian Fox, Samuel A. Danziger, Frances Seymour
Publikováno v:
Blood. 132:3296-3296
Introduction Relapsed and refractory multiple myeloma (RRMM) remains a challenging disease to treat due to its heterogeneity and complexity. There is an urgent need for novel combination strategies, including immunotherapy. The study of the tumour an
Autor:
Michael A Bauer, Cody Ashby, Ruslana Tytarenko, Purvi Patel, Sharmilan Thanendrarajan, Faith E. Davies, Jonathan J Keats, Frits van Rhee, Anjan Thakurta, Erin Flynt, Maurizio Zangari, Daniel Auclair, Aneta Mikulasova, Brian A Walker, Christopher P. Wardell, Jake Gockley, Andrew Dervan, Maria Ortiz, Yan Wang, Carolina Schinke, Gareth J. Morgan
Publikováno v:
Blood. 132:408-408
Introduction: Chromothripsis and chromoplexy are gross structural events that deregulate multiple genes simultaneously and may help explain rapid changes in clinical behavior. Previous screening studies in multiple myeloma (MM) using copy number arra