Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Almo, Steven C."'
Publikováno v:
bioRxiv
The use of bispecific antibodies as T cell engagers can bypass the normal TCR-MHC interaction, redirect the cytotoxic activity of T-cells, and lead to highly efficient tumor cell killing. However, this immunotherapy also causes significant on-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3884a9eab7b74f0201db9d8c0f1aa62
https://europepmc.org/articles/PMC10274768/
https://europepmc.org/articles/PMC10274768/
Autor:
Hegde, Raghurama P., Pavithra, Gowribidanur C., Dey, Debayan, Almo, Steven C., Ramakumar, S., Ramagopal, Udupi A.
Protein crystallization is one of the major bottlenecks in protein structure elucidation with new strategies being constantly developed to improve the chances of crystallization. Generally, well-ordered epitopes possessing complementary surface and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdac4882ab57fdd233f7a0a16fa3eabd
https://europepmc.org/articles/PMC5563152/
https://europepmc.org/articles/PMC5563152/
Autor:
Lamont, Deanna, Mukherjee, Gayatri, Kumar, P. Rajesh, Samanta, Dibyendu, McPhee, Caroline G., Kay, Thomas W. H., Almo, Steven C., DiLorenzo, Teresa P., Serreze, David V.
Self-reactive T cells must escape thymic negative selection to mediate pathogenic autoimmunity. In the NOD mouse model of autoimmune diabetes, several β cell-cytotoxic CD8 T cell populations are known, with the most aggressive of these represented b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4849ec84bf00bd719b23ed5d7b0c4352
https://europepmc.org/articles/PMC4134999/
https://europepmc.org/articles/PMC4134999/
Autor:
Hitchcock, Daniel S, Fan, Hao, Kim, Jungwook, Vetting, Matthew, Hillerich, Brandan, Seidel, Ronald D, Almo, Steven C, Shoichet, Brian K, Sali, Andrej, Raushel, Frank M
Publikováno v:
Journal of the American Chemical Society, vol 135, iss 37
A substantial challenge for genomic enzymology is the reliable annotation for proteins of unknown function. Described here is an interrogation of uncharacterized enzymes from the amidohydrolase superfamily using a structure-guided approach that integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::a320e455ac927347e9f6674c5df55ff2
https://escholarship.org/uc/item/1r427004
https://escholarship.org/uc/item/1r427004
Autor:
Fan, Hao, Hitchcock, Daniel S, Seidel, Ronald D, Hillerich, Brandan, Lin, Henry, Almo, Steven C, Sali, Andrej, Shoichet, Brian K, Raushel, Frank M
Publikováno v:
Journal of the American Chemical Society, vol 135, iss 2
Of the over 22 million protein sequences in the nonredundant TrEMBL database, fewer than 1% have experimentally confirmed functions. Structure-based methods have been used to predict enzyme activities from experimentally determined structures; howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::993f98a57380fcdea73ccc1dba5d4588
https://escholarship.org/uc/item/0m64v23n
https://escholarship.org/uc/item/0m64v23n
Autor:
Roche, Camille J., Malashkevich, Vladimir, Balazs, Tatiana C., Dantsker, David, Chen, Qiuying, Moreira, Juan, Almo, Steven C., Friedman, Joel M., Hirsch, Rhoda Elison
Hemoglobin (Hb) E (β-Glu26Lys) remains an enigma in terms of its contributions to red blood cell (RBC) pathophysiological mechanisms; for example, EE individuals exhibit a mild chronic anemia, and HbE/β-thalassemia individuals show a range of clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1302e51e67a17016447354cda427b1cb
https://europepmc.org/articles/PMC3123109/
https://europepmc.org/articles/PMC3123109/
Autor:
Kellett, Whitney F., Brunk, Elizabeth, Desai, Bijoy J., Fedorov, Alexander A., Almo, Steven C., Gerlt, John A., Rothlisberger, Ursula, Richards, Nigel G. J.
The fermentation-respiration switch (FrsA) protein in Vibrio vulnificus was recently reported to catalyze the cofactor-independent decarboxylation of pyruvate. We now report quantum mechanical/molecular mechenical calculations that examine the energe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::2fdf27bff60efa9da039e797feec9b02
https://infoscience.epfl.ch/record/185797
https://infoscience.epfl.ch/record/185797
Autor:
Kellett, Whitney F., Brunk, Elizabeth, Desai, Bijoy, Fedorov, Alexander A., Almo, Steven C., Gerlt, John A., Rothlisberger, Ursula, Richards, Nigel G. J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::d8b438f5715e2f41db854c203f1378b4
https://infoscience.epfl.ch/record/196910
https://infoscience.epfl.ch/record/196910
Autor:
Wang, Hua, Fedorov, Alexander A, Fedorov, Elena V, Hunt, Debbie M, Rodgers, Angela, Douglas, Holly L, Acely Garza-Garcia, Bonanno, Jeffrey B, Almo, Steven C, Luiz Pedro Sório De Carvalho
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49bfd9f1d9ea9d7f08383149caad8129
Autor:
Wang, Hua, Fedorov, Alexander A, Fedorov, Elena V, Hunt, Debbie M, Rodgers, Angela, Douglas, Holly L, Acely Garza-Garcia, Bonanno, Jeffrey B, Almo, Steven C, Luiz Pedro Sório De Carvalho
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infection, macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c412d71319b4737695966c92dbc73283