Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alicia Steffens"'
Autor:
Michael Drumm, Wenxia Wang, Thomas K. Sears, Kirsten Bell-Burdett, Rodrigo Javier, Kristen Y. Cotton, Brynna T. Webb, Kayla T. Byrne, Dusten Unruh, Vineeth Thirunavu, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Rimas V. Lukas, Joanna J. Phillips, Esraa Mohamed, John D. Finan, Lucas Santana-Santos, Amy B. Heimberger, Colin K. Franz, Jonathan E. Kurz, Jessica W. Templer, Geoffrey T. Swanson, Craig Horbinski
Publikováno v:
The Journal of clinical investigation, vol 133, iss 12
Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH-wild type (IDHwt) gliomas to cause se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125e96da5b909fb444616a484ece9056
https://escholarship.org/uc/item/1hp8c54d
https://escholarship.org/uc/item/1hp8c54d
Autor:
Mireille, Bitar, Yevgen, Chornenkyy, Margaret E, Flanagan, Alicia, Steffens, Kathleen, McCortney, Craig, Horbinski
Publikováno v:
J Neuropathol Exp Neurol
While the coexistence of focal cortical dysplasia (FCD) and grade 1 noninfiltrative gliomas has been described, to date, only rare case reports have described FCD adjacent to infiltrating gliomas. We therefore sought to determine how often FCD-like f
Autor:
Kirsten Bell Burdett, Dusten Unruh, Michael Drumm, Alicia Steffens, Jonathan Lamano, Jonathan Judkins, Margaret Schwartz, Rodrigo Javier, Christina Amidei, Eric S. Lipp, Katherine B. Peters, Albert Lai, Blaine S. C. Eldred, Amy B. Heimberger, Kathleen McCortney, Denise M. Scholtens, Craig Horbinski
Publikováno v:
Blood.
Venous thromboembolism (VTE) is a life-threating condition that is common in patients with adult-type diffuse gliomas, yet thromboprophylaxis is controversial because of possible intracerebral hemorrhage. Effective VTE prediction models exist for oth
Autor:
Kirsten B Burdett, Dusten Unruh, Michael Drumm, Jonathan Lamano, Margaret Schwartz, James Chandler, Rodrigo Javier, Alicia Steffens, Christina Amidei, Eric S Lipp, Katherine B Peters, Albert Lai, Blaine Eldred, Kathleen McCortney, Amy Heimberger, Denise Scholtens, Craig Horbinski
Publikováno v:
Neuro-Oncology. 24:vii241-vii242
Venous thromboembolism (VTE) is a common paraneoplastic complication in patients with adult-type diffuse gliomas. VTE greatly diminishes quality-of-life, and can even be life-threatening. While effective VTE prediction models exist for other cancers,
Autor:
Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia
While immunotherapies have shown durable responses for multiple tumors, their efficacy remains limited in some advanced cancers, including glioblastoma. This may be due to differences in the immune landscape, as the glioblastoma microenvironment stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c740fdfe6628cb7a17646eb551b525
https://doi.org/10.1101/2022.03.07.483365
https://doi.org/10.1101/2022.03.07.483365
Autor:
Adam Lauko, Josephine Volovetz, Soumya M. Turaga, Defne Bayik, Daniel J. Silver, Kelly Mitchell, Erin E. Mulkearns-Hubert, Dionysios C. Watson, Kiran Desai, Manav Midha, Jing Hao, Kathleen McCortney, Alicia Steffens, Ulhas Naik, Manmeet S. Ahluwalia, Shideng Bao, Craig Horbinski, Jennifer S. Yu, Justin D. Lathia
Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive recurrence. The precise mechanisms underlying CSC therapeutic resistance, namely inhibition of cell death, are unclear. We built on previous observations that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3ff12d91437742d15e07e115d78457
https://doi.org/10.1101/2021.12.21.473663
https://doi.org/10.1101/2021.12.21.473663
Autor:
Kwok Ling Kam, Alicia Steffens, Craig Horbinski, Matthew McCord, Kathleen McCortney, Rodrigo Javier
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-8 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
A subset of gliomas has DNA repair defects that lead to hypermutated genomes. While such tumors are resistant to alkylating chemotherapies, they may also express more mutant neoantigens on their cell surfaces, and thus be more responsive to immunothe
Autor:
Sean Grimm, Milan G. Chheda, Kwok Ling Kam, Jeffrey Raizer, Sean Sachdev, Alicia Steffens, Karan Dixit, Tim J. Kruser, Rimas V. Lukas, Michael Drumm, Roger Stupp, Craig Horbinski, Priya Kumthekar, Rodrigo Javier, Matthew McCord, Kathleen McCortney
Publikováno v:
Neuro-Oncology. 22:470-479
Background Progress in extending the survival of glioblastoma (GBM) patients has been slow. A better understanding of why patient survival remains poor is critical to developing new strategies. Postmortem studies on GBM can shed light on why patients
Autor:
Michael Drumm, Wenxia Wang, Kirsten B Burdett, Thomas Sears, Rodrigo Javier, Kristen Cotton, Brynna Webb, Jacob Stolz, Kayla Byrne, Dusten Unruh, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Omar Bushara, Alyssa Weston, Suning He, Rimas Lukas, John Finan, Colin Franz, Jonathan Kurz, Jessica Templer, Geoff Swanson, Craig Horbinski
Publikováno v:
Neuro-Oncology. 24:vii27-vii27
Tumor-associated epilepsy (TAE) is a frequent complication of diffusely infiltrative gliomas, and impairs quality-of-life. We previously showed that isocitrate dehydrogenase 1 mutant (IDHmut) gliomas were associated with preoperative seizures, and th
Autor:
Michael Drumm, Wenxia Wang, Kirsten Bell Bell Burdett, Thomas Sears, Rodrigo Javier, Kristen Cotton, Brynna Webb, Dusten Unruh, Jordain Walshon, Alicia Steffens, Kathleen McCortney, Omar Bushara, Alyssa Weston, Suning He, John Finan, Colin Franz, Jonathan Kurz, Jessica Templer, Geoff Swanson, Craig M. Horbinski
Publikováno v:
Journal of Clinical Oncology. 40:2064-2064
2064 Background: Tumor-associated epilepsy (TAE) is a frequent complication of diffusely infiltrative gliomas. TAE not only impairs quality-of-life, but it can even be life-threatening. Furthermore, glioma cells have been shown to proliferate and mig