Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Pedro R. Lowenstein"'
High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme
Autor:
Maria G. Castro, Padma Kadiyala, Robert Doherty, Minzhi Yu, Neha Kamran, David Altshuler, Dan Li, Rui Kuai, Pedro R. Lowenstein, James J. Moon, Marta Edwards, Fernando M. Nunez, Anna Schwendeman
Publikováno v:
ACS Nano.
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no cure. Treatment effectiveness for GBM has been limited due to tumor heterogeneity, an immunosuppressive tumor microenvironment (TME) and the presence of the blo
Publikováno v:
Molecular Cancer Therapeutics. 13:3024-3036
The success of immunotherapeutic approaches targeting glioblastoma multiforme (GBM) demands a robust antiglioma T-cell cytotoxic and memory response. Recent evidence suggests that rapamycin regulates T-cell differentiation. Herein, we tested whether
Autor:
Liliana M. Lacayo, Johnny Krasinkiewicz, Catherine Farrokhi, Mariana Puntel, Maria G. Castro, Kyle R. Kelson, Ghulam Muhammad A.K.M., Sukhpreet Kaur, Nathan VanderVeen, Philip Ng, Sean Kennedy, Robert N. Pechnick, Christopher Paran, Pedro R. Lowenstein, Ashley Appelhans, Kurt M. Kroeger, Alireza Salem, Donna Palmer, Chunyan Liu
Publikováno v:
Toxicology and Applied Pharmacology. 268:318-330
Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered by their immunogenicity and the presence of anti-Ad immunity in humans. We reported the effi
Autor:
Daniel Zamler, Maria G. Castro, Pedro R. Lowenstein, Philip Ng, Nicholas Raja, Henry D. Appelman, Elizabeth Yi, Marta Dzaman, Donna Palmer, Nathan VanderVeen
Publikováno v:
Human gene therapy methods. 27(3)
Glioblastoma multiforme (GBM) is the most commonly occurring primary brain cancer in adults, in whom its highly infiltrative cells prevent total surgical resection, often leading to tumor recurrence and patient death. Our group has discovered a gene
Autor:
Mariela A. Moreno Ayala, Marianela Candolfi, Neha Kamran, Pedro R. Lowenstein, Marta Dzaman, Gregory J. Baker, Maria G. Castro
Publikováno v:
Gene Therapy for Neurological Disorders : Methods and Protocols
Gene Therapy for Neurological Disorders ISBN: 9781493932702
Gene Therapy for Neurological Disorders ISBN: 9781493932702
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with a median survival of 16.2–21.2 months post diagnosis (Stupp et al., N Engl J Med 352(10): 987–996, 2005). Because of its location, complete surgical resection is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ffa175e24e22a70f812f6a4ad09734
https://link.springer.com/protocol/10.1007/978-1-4939-3271-9_31
https://link.springer.com/protocol/10.1007/978-1-4939-3271-9_31
Autor:
Kyle R. Kelson, Philip Ng, Robert N. Pechnick, Pedro R. Lowenstein, Kurt M. Kroeger, Weidong Xiong, Alireza Salem, A.K.M. Ghulam Muhammad, Chunyan Liu, Donna Palmer, Liliana M. Lacayo, Mariana Puntel, Maria G. Castro, Catherine Farrokhi
Publikováno v:
Human Gene Therapy Methods. 23:271-284
Adenoviral vectors (Ads) have been evaluated in clinical trials for glioma. However, systemic immunity against the vectors can hamper therapeutic efficacy. We demonstrated that combined immunostimulation and cytotoxic gene therapy provides long-term
Autor:
Kurt M. Kroeger, Maria G. Castro, Gwendalyn D. King, Pedro R. Lowenstein, Akm Ghulam Muhammad, Serguei Bannykh, Yohei Mineharu, Chunyan Liu
Publikováno v:
Clinical Cancer Research. 17:4705-4718
Purpose: Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Clinical trials for GBM using dendritic cell (DC) vaccination resulted in antitumor immune responses. Herein, we tested the hypothesis that combining in situ (intratumoral) Ad-Fl
Autor:
Maria G. Castro, Philip Ng, Donna Palmer, Mariana Puntel, A.K.M. Ghulam Muhammad, Weidong Xiong, Pedro R. Lowenstein, Kurt M. Kroeger, Gwendalyn D. King, Daniel Larocque
Publikováno v:
Journal of Virology. 82:4680-4684
Gene therapy is proposed as a novel therapeutic strategy for treating glioblastoma multiforme (GBM), a devastating brain cancer. In the clinic, antivector immune responses pose formidable challenges. Herein we demonstrate that high-capacity adenoviru
Autor:
Charlene M. Manalo, Kurt M. Kroeger, Chunyan Liu, Maria G. Castro, Pedro R. Lowenstein, Catherine Bresee, Akm Ghulam Muhammad, Robert N. Pechnick, Gwendalyn D. King, Marianela Candolfi
Publikováno v:
Molecular Therapy. 16:682-690
Glioblastoma multiforme (GBM) is an invasive and aggressive primary brain tumor which is associated with a dismal prognosis. We have earlier developed a macroscopic, intracranial, syngeneic GBM model, in which treatment with adenoviral vectors (Ads)
Autor:
Pedro R. Lowenstein, Stephen B. Dunnett, Eduardo Miguel Torres, Maria G. Castro, Christelle Monville
Publikováno v:
Molecular Brain Research. 137:1-10
We have investigated the in vivo dynamics of an adenovirus-based, LacZ expressing vector, RAd36, at different doses, when injected unilaterally into the corpus striatum of normal rats. We have further investigated the characteristics of this vector i