Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joan J. Guinovart"'
Autor:
Dolores Velasco, Ignacio Fita, Mireia Díaz-Lobo, Jaume Garcia-Amorós, Joan C. Ferrer, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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This journal is © The Royal Society of Chemistry 2015. Glycogen is a polymer of α-1,4- and α-1,6-linked glucose units that provides a readily available source of energy in living organisms. Glycogen synthase (GS) and glycogen phosphorylase (GP) ar
Autor:
Ignacio Fita, Alda Lisa Concia, Mireia Díaz-Lobo, Pere Clapés, Joan C. Ferrer, Livia Gómez, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Glycogen synthase (GS) and glycogen phosphorylase (GP) are the key enzymes that control, respectively, the synthesis and degradation of glycogen, a multi-branched glucose polymer that serves as a form of energy storage in bacteria, fungi and animals.
Publikováno v:
Journal of Biological Chemistry. 284:6370-6378
Eukaryotic glycogen synthase activity is regulated by reversible phosphorylation at multiple sites. Of the two GS isoforms found in mammals, the muscle enzyme (muscle glycogen synthase) has received more attention and the relative importance of every
Publikováno v:
Journal of Biological Chemistry. 276:23858-23866
We used metabolic control analysis to determine the flux control coefficient of phosphorylase on glycogen synthesis in hepatocytes by titration with a specific phosphorylase inhibitor (CP-91149) or by expression of muscle phosphorylase using recombin
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Glycogen synthase, a central enzyme in glucose metabolism, catalyzes the successive addition of α-1,4-linked glucose residues to the non-reducing end of a growing glycogen molecule. A non-catalytic glycogen-binding site, identified by x-ray crysta
Autor:
Mar García-Rocha, Eulàlia Montell, Carlos Lerı́n, Teresa Nolasco, Joan J. Guinovart, Anna M. Gómez-Foix
Publikováno v:
The Biochemical journal. 378(Pt 3)
Pharmacological inhibition of liver GP (glycogen phosphorylase), which is currently being studied as a treatment for Type II (non-insulin-dependent) diabetes, may affect muscle glycogen metabolism. In the present study, we analysed the effects of the
Autor:
Cristián Favre, Joan J. Guinovart, Roger R. Gomis, Juan Ferrer, Josep M. Fernández-Novell, Mar García-Rocha
Publikováno v:
The Journal of biological chemistry. 278(11)
Glucose 6-phosphate (Glc-6-P) produced in cultured hepatocytes by direct phosphorylation of glucose or by gluconeogenesis from dihydroxyacetone (DHA) was equally effective in activating glycogen synthase (GS). However, glycogen accumulation was highe
Autor:
Juan C. Ferrer, Mar García-Rocha, Joan J. Guinovart, Josep M. Fernández-Novell, Susanna Baqué
Publikováno v:
Technological and Medical Implications of Metabolic Control Analysis ISBN: 9780792361893
As Joseph Larner (1990) pointed out, glycogen has been a major catalyst in the formulation of many concepts of modern biology. A number of broad principles have emerged from studies of glycogen metabolism. Thus, covalent regulation by phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9326212a2cdac66de2e449a45b1536f
https://doi.org/10.1007/978-94-011-4072-0_23
https://doi.org/10.1007/978-94-011-4072-0_23
Publikováno v:
European journal of biochemistry. 236(3)
The direct effects of dexamethasone on glycogen synthase and phosphorylase and glycogen content have been investigated in primary cultured rat hepatocytes. Dexamethasone induced the transient translocation of glycogen synthase from the soluble to the
Publikováno v:
Biochemistry. 34(19)
Allosteric switching between inactive and active conformational states in muscle glycogen phosphorylase alters the pattern of van der Waals contacts and hydrogen bonds between two helices located at the dimer interface of the enzyme. Alanine was subs