Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maria Sasvari-Szekely"'
Autor:
Tatjana Spasokoukotskaja, Maria Staub, Staffan Eriksson, Gergely Keszler, Maria Sasvari-Szekely
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1147-1151
The activity of deoxycytidine kinase (dCK) has been shown to be enhanced upon genotoxic stress in human lymphocytes, and reversible phosphorylation of the enzyme has been implicated in the activation process. Here, we provide compelling evidence that
Autor:
Zygmunt Kazimierczuk, Gergely Keszler, Maria Staub, Károly Szikla, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely
Publikováno v:
Biochemical Pharmacology. 65:563-571
Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175],
Publikováno v:
Acta Biochimica Polonica. 48:251-256
Deoxycytidine kinase (dCK) is one of the key enzymes of deoxynucleoside salvage supplying resting lymphocytes with DNA precursors for synthesis and repair. The level of dCK activity is especially important in chemotherapy with the use of deoxynucleos
Autor:
Maria Sasvari-Szekely, Maria Staub, Gergely Keszler, Tatjana Spasokoukotskaja, Zsolt Csapó, Szula Virga
Publikováno v:
ChemInform. 36
Stimulation of the activity of deoxycytidine kinase (dCK), the principal deoxynucleoside salvage enzyme, has been recently considered as a protective cellular response to a wide range of agents interfering with DNA repair and apoptosis. In light of t
Publikováno v:
Advances in experimental medicine and biology. 431
Deoxycytidine kinase was shown to be activated during 2-chlorodeoxyadenosine (CdA) treatment of human lymphocytes, under the conditions when the DNA synthesis is inhibited. As the increase of dCK activity was shown in crude protein extracts, without
Publikováno v:
Biochemical and biophysical research communications. 174(2)
In addition to the water-soluble deoxyliponucleotides (Spasokukotskaja et al. (1988), Biochem. Biophys. Res. Commun. 155, 923), a lipid compound was shown to be labeled from external 3H-deoxycytidine (5-3H-CdR) in infant tonsillar lymphocytes. Chlorp
Autor:
Maria Sasvari-Szekely, Ferenc A. Antoni, Tatjana Spasokukotskaja, J. Taljanidisz, Maria Staub
Publikováno v:
Immunology Letters. 15:109-115
Peanut agglutinin (PNA), a d -galactose specific lectin, agglutinated 10–18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA + cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA poly
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 762:452-457
The DNA synthesis system of freshly isolated tonsillar lymphocytes and those stimulated by phytohaemagglutinin were compared by different methods. Both cell populations had high DNA polymerase α and thymidine kinase activities, as well as a high rat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 395:221-228
The present paper describes a rapid, specific and sensitive method for quantitating ribonucleoside triphosphates (ATP and UTP) in cell extracts. The principle of the method is based on the synthesis of a ribonucleotide polymer in the presence of UTP,
Autor:
Maria Sasvari-Szekely, Tatjana Spasokukotskaja, Katalin Merétey, Ferenc A. Antoni, Maria Staub
Publikováno v:
Biochemical Medicine. 19:218-230
Cellular [ 3 H]uridine uptake and incorporation into RNA were compared in human tonsil lymphocyte subpopulations obtained by separation on nylon-wool column. While the nonadherent subpopulation, Fraction I, contained 74.5 ± 8% E-rosette forming T-ly