Zobrazeno 1 - 10
of 20
pro vyhledávání: '"B. Glick"'
Publikováno v:
Cancer Research. 81:2029-2029
UV induced DNA damage is the primary driver of human skin cancer. UV can also cause endoplasmic reticulum (ER) stress, but the role of unfolded protein response (UPR) in the cellular response to UV exposure is not clear. Inositol-requiring enzyme 1α
Autor:
S. Rozzo, Xue Song, M. Brouillette, Alan M. Mendelsohn, J.J. Wu, G. Han, J. Bagel, I. Chopra, B. Glick
Publikováno v:
Value in Health. 24:S223
Publikováno v:
Cancer Research. 80:5839-5839
IRE1α is a well-characterized stress response signaling protein that adapts the cell to conditions of endoplasmic reticulum (ER) stress. In addition to well-established sources of ER stress such as viral infection, hypoxia and nutrient deprivation,
Publikováno v:
Cancer Research. 69:4407-4414
Several mucosotropic human papillomaviruses (HPV), including HPV type 16 (HPV-16), are etiologic agents of a subset of anogenital cancers and head and neck squamous cell carcinomas. In mice, HPV-16 E7 is the most potent of the papillomaviral oncogene
Autor:
Charles Vinson, Julian M. Rozenberg, Vikas Rishi, András Orosz, Adam B. Glick, Jaideep Moitra
Publikováno v:
Mol Cancer Res
We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using t
Publikováno v:
Molecular Cancer Research. 6:509-516
Cripto-1 is an epidermal growth factor-Cripto/FRL1/Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors. Here we report that in the two-stage mouse skin carcinogenesis model, Cr
Autor:
Maria Jose Pajares, Shraddha A. Ravani, Sergei Koslov, Martin J. Lavin, Michael F. Jobling, Julia Kirshner, Mary Helen Barcellos-Hoff, Adam B. Glick, Yosef Shiloh
Publikováno v:
Cancer Research. 66:10861-10869
Ionizing radiation causes DNA damage that elicits a cellular program of damage control coordinated by the kinase activity of ataxia telangiectasia mutated protein (ATM). Transforming growth factor β (TGFβ)-1, which is activated by radiation, is a p
Autor:
Adam B. Glick, Nicholas A. Frost, Michelle R. Levy, Vikas Rishi, Jaideep Moitra, Charles Vinson, Stuart H. Yuspa, Maxim V Myakishev, Michael J. Gerdes, Sang Won Park, Asha Acharya
Publikováno v:
Cancer Research. 66:7578-7588
To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding.
Autor:
Adam B. Glick
Publikováno v:
Cancer Biology & Therapy. 3:276-283
TGF ? 1 was initially identified in culture media from transformed cells as part of a factor that could produce a transformed phenotype in a nontransformed cell line. Subsequently this activity was separated into TGF? and TGF? an EGF receptor ligand.
Publikováno v:
Cancer Research. 77:2673-2673
Heterogeneity in tumor immune responses is a poorly understood yet critical parameter for successful immunotherapy. We used doxycycline-inducible epidermal squamous cancer models driven by oncogenic Ras to test whether the origin of the tumor-initiat