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pro vyhledávání: '"Scott M. Norberg"'
Autor:
Dana D. Hu-Lowe, Barbara Sennino, Bruce Freimark, Rachel B. Davis, Michael R. Mancuso, Tsutomu Nakahara, Scott M. Norberg, Tetsuichiro Inai, Shaun O'Brien, Peter C. Brooks, Donald M. McDonald, David R. Shalinsky, Virginia J. Yao
Publikováno v:
Journal of Clinical Investigation. 116:2610-2621
Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment ends. In the present study, regrowth of blood vessels in spontaneous RIP-Tag2 tumors and im
Publikováno v:
Cancer research. 66(3)
Antibodies and other macromolecular therapeutics can gain access to tumor cells via leaky tumor vessels. Inhibition of vascular endothelial growth factor (VEGF) signaling can reduce the vascularity of tumors and leakiness of surviving vessels, but li