Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Joan J. Guinovart"'
Autor:
Jordi Duran, Giorgia Testoni, Elena Lopez-Rodriguez, María Isabel Hernández-Álvarez, Joan J. Guinovart, Mònica Aguilera, Neus Prats, Bárbara Olmeda, Jesús Pérez-Gil
Publikováno v:
Human Molecular Genetics. 29:3554-3565
The glycogenin knockout mouse is a model of Glycogen Storage Disease type XV. These animals show high perinatal mortality (90%) due to respiratory failure. The lungs of glycogenin-deficient embryos and P0 mice have a lower glycogen content than that
Publikováno v:
FEBS Lett
Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during food deprivation. To this en
Autor:
del Rio Ja, Brewer Mk, Jordi Duran, Prat N, López-Soldado I, Pellegrini P, Varea O, Joan J. Guinovart, Guitart A, Arnau Hervera, Aguilera M
BackgroundLafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the neurologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4310a229fb376b919f0cedb9172e6c
https://doi.org/10.1101/2021.06.03.446965
https://doi.org/10.1101/2021.06.03.446965
Publikováno v:
The Journal of Biological Chemistry
Muscle glycogen depletion has been proposed as one of the main causes of fatigue during exercise. However, few studies have addressed the contribution of liver glycogen to exercise performance. Using a low-intensity running protocol, here, we analyze
Publikováno v:
The Journal of Biological Chemistry
Hepatic glycogen metabolism is impaired in diabetes. We previously demonstrated that strategies to increase liver glycogen content in a high-fat-diet mouse model of obesity and insulin resistance led to a reduction in food intake and ameliorated obes
Autor:
Patrícia Coelho, Pranvera Sadiku, Alex von Kriegsheim, Leila Reyes, David H. Dockrell, Robert Grecian, Jordi Duran, Christopher J Graham, Simone Arienti, Abel Acosta-Sanchez, Veronica M. Dardé, Privjyot Jheeta, Ananda S. Mirchandani, Gordon G. Paterson, A. A. Roger Thompson, David Sammut, Tyler Morrison, Martin A. Bewley, Ailing Zhang, Joseph A Willson, Massimiliano Mazzone, Kenneth Baillie, Moira K. B. Whyte, Tobias Griessler, Sarah R. Walmsley, Emily R. Watts, Peter Carmeliet, Jessie-May Morgan, Eilise M. Ryan, John P. Thomson, Manuel A. Sanchez Garcia, Bart Ghesquière, Joan J. Guinovart, Richard R. Meehan, Gio Rodriguez-Blanco, Jason M. Young
Publikováno v:
Sadiku, P, Willson, J A, Ryan, E M, Sammut, D, Coelho, P, Watts, E R, Grecian, R, Young, J M, Bewley, M, Arienti, S, Mirchandani, A S, Sanchez Garcia, M A, Morrison, T, Zhang, A, Reyes, L, Griessler, T, Jheeta, P, Paterson, G G, Graham, C J, Thompson, J P, Baillie, K, Thompson, A A R, Morgan, J-M, Acosta-Sanchez, A, Dardé, V M, Duran, J, Guinovart, J J, Rodriguez-Blanco, G, Von Kriegsheim, A, Meehan, R R, Mazzone, M, Dockrell, D H, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2021, ' Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis ', Cell Metabolism, vol. 33, no. 2, pp. 411-423.e4 . https://doi.org/10.1016/j.cmet.2020.11.016
Cell Metabolism
Cell Metabolism
Summary Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad74cc910e5a97db33fae4b7012689
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
Alteration of mitochondrial function in the livers of mice with glycogen branching enzyme deficiency
Autor:
Jordi Duran, Giorgia Testoni, Jerzy Duszyński, Malgorzata Bejtka, Dominika Malinska, Joan J. Guinovart
Publikováno v:
Biochimie. 186
Glycogen storage disease type IV (GSD IV) is caused by mutations in the glycogen branching enzyme gene (GBE1) that lead to the accumulation of aberrant glycogen in affected tissues, mostly in the liver. To determine whether dysfunctional glycogen met
Autor:
Jordi Duran, Juan Antonio López, Rebeca Acín-Pérez, Daniel Jimenez-Blasco, Alfonso Mora, Cristina Casanueva-Benítez, José Antonio Enríquez, Ayelén M Santamans, Jesús Vázquez, Juan P. Bolaños, Aránzazu Pintor-Chocano, Francisco Gonzalez-Romero, María Villlalba-Orero, Bárbara González-Terán, Luis Leiva-Vega, Joan J. Guinovart, Jesús Jiménez-Borreguero, Guadalupe Sabio, Elena Rodríguez, Patricia Aspichueta, Valle Montalvo-Romeral
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
instname
PLoS Biology, Vol 19, Iss 11, p e3001447 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS Biology
instname
PLoS Biology, Vol 19, Iss 11, p e3001447 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS Biology
During the first weeks of postnatal heart development, cardiomyocytes undergo a major adaptive metabolic shift from glycolytic energy production to fatty acid oxidation. This metabolic change is contemporaneous to the up-regulation and activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3520bf7f9aac21066df6b0dff79c93
http://hdl.handle.net/10810/54617
http://hdl.handle.net/10810/54617
Autor:
Alicja Brudnicka, Jordi Duran, Joan J. Guinovart, Giorgia Testoni, Jerzy Duszyński, Dominika Malinska
Publikováno v:
Archives of biochemistry and biophysics. 695
Glycogen branching enzyme (GBE1) introduces branching points in the glycogen molecule during its synthesis. Pathogenic GBE1 gene mutations lead to glycogen storage disease type IV (GSD IV), which is characterized by excessive intracellular accumulati
Publikováno v:
Diabetologia. 60:1076-1083
Liver glycogen plays a key role in regulating food intake and blood glucose. Mice that accumulate large amounts of this polysaccharide in the liver are protected from high-fat diet (HFD)-induced obesity by reduced food intake. Furthermore, these anim