Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Scott M. Norberg"'
Publikováno v:
Otolaryngologic clinics of North America. 54(4)
This article reviews the most recent literature describing clinical advances in adoptive cell therapy for patients with head and neck cancer. Clinical trials with tumor-infiltrating lymphocyte and gene-engineered T-cell receptor T-cell therapy are hi
Autor:
James L. Gulley, Charalampos S. Floudas, Lisa M. Cordes, Fatima Karzai, Jeffrey Schlom, Elizabeth Lamping, Julius Strauss, Jason M. Redman, Ravi A. Madan, Deneise C Francis, Michell Manu, Caroline Jochems, Renee N. Donahue, Scott M. Norberg, Marijo Bilusic, Jenn Marte, Frank K. Bedu-Addo, Christian S. Hinrichs, Houssein Abdul Sater, Lauren Virginia Wood
Publikováno v:
Journal of Clinical Oncology. 39:2501-2501
2501 Background: There are more than 630,000 cases of HPV associated malignancies including cervical, oropharyngeal and anal cancer worldwide annually. HPV 16 is responsible for the majority of these cases. About 15-20% of HPV associated malignancies
Publikováno v:
Clinical Genitourinary Cancer. 12:e225-e227
Spontaneous tumor lysis syndrome (STLS) is a rare oncologic emergency caused by acute and massive death of tumor cells before the initiation of any anticancer therapy. It is commonly associated with aggressive hematological malignancies; however, it
Autor:
Sujana Movva, Scott M. Norberg
Publikováno v:
Current Treatment Options in Oncology. 16
The treatment of sarcomas has been challenging due to their heterogeneity, rarity in the general population, relative insensitivity to chemotherapeutics, and lack of effective targeted agents. One of the first major breakthroughs in the treatment of
Autor:
Dana D. Hu-Lowe, Barbara Sennino, Bruce Freimark, Rachel B. Davis, Michael R. Mancuso, Tsutomu Nakahara, Scott M. Norberg, Tetsuichiro Inai, Shaun O'Brien, Peter C. Brooks, Donald M. McDonald, David R. Shalinsky, Virginia J. Yao
Publikováno v:
Journal of Clinical Investigation. 116:2610-2621
Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment ends. In the present study, regrowth of blood vessels in spontaneous RIP-Tag2 tumors and im
Autor:
Roger B. Davis, Lori C. Gowen, Hiroya Hashizume, Matthew L. Springer, Shaun O'Brien, Amy Haskell, Donald M. McDonald, Betty Y. Y. Tam, Barbara Sennino, Scott M. Norberg, Gavin Thurston, Calvin J. Kuo, Shuji Joho, Tomomi Kamba, Keith D. Anderson, Michael R. Mancuso
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H560-H576
Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function. However, VEGF is a survival factor for many tumor vessels, and there are clues that some normal blood vessels may also depend on VEGF
Autor:
Scott M. Norberg, Richard Murray, Cecile J. Favre, Patricia Parsons-Wingerter, Donald M. McDonald, Iain M Kasman, Ursula Jeffry, Anette Magnussen, Peter Baluk, Sara Zanivan, Alberto Rissone
Publikováno v:
The American Journal of Pathology. 167:193-211
Integrin alpha5beta1 is among the proteins overexpressed on tumor vessels and is a potential target for diagnostics and therapeutics. Here, we mapped the distribution of alpha5beta1 integrin in three murine tumor models and identified sites of expres
Autor:
Luis A. Garza, Susan M. Fischer, Brinda Alagesan, Scott M. Norberg, Hanz Blatt, George Cotsarelis, John A. Lawson, Tailun Zhao, Yaping Liu, Zaixin Yang, Dorothy E. Loy, David C. Stanton, Gurpreet Ahluwalia, Lee Carrasco, Garret A. FitzGerald
Publikováno v:
Science Translational Medicine. 4
Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D(2) synthase (PTGDS) is elevated at
Publikováno v:
Cancer research. 66(3)
Antibodies and other macromolecular therapeutics can gain access to tumor cells via leaky tumor vessels. Inhibition of vascular endothelial growth factor (VEGF) signaling can reduce the vascularity of tumors and leakiness of surviving vessels, but li
Autor:
Peter Baluk, Anette Magnussen, Donald M. McDonald, Scott M. Norberg, Ian Kasman, Richard Murray
Publikováno v:
Cancer research. 65(7)
Integrin alpha(5)beta(1) is overexpressed on endothelial cells of tumor vessels and is uniformly and rapidly accessible to antibodies in the bloodstream. Here, we determined whether antibodies rapidly gain access to integrin overexpressed on the ablu