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Autor:
Terrance P. Snutch, Changiz Taghibiglou, Sathiya Sekar, John G. Howland, Venkat Gopalakrishnan, Quentin Greba, Wendie N. Marks
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 47:1530-1536
Insulin-mediated signalling in the brain is critical for neuronal functioning. Insulin resistance is implicated in the development of some neurological diseases, although changes associated with absence epilepsy have not been established yet. Therefo
Autor:
Jaanus Harro, Marten Vares, Kai Tiitsaar, Mait Metelitsa, Kadri Kõiv, Margit Kaldmäe, Karita Laugus, Ruth Shimmo
Publikováno v:
Pharmacology Biochemistry and Behavior. 171:10-19
High level of positive affectivity acts as a protective factor against adverse effects of stress and decreases vulnerability to mood disorders and drug abuse. Fifty-kHz ultrasonic vocalizations (50-kHz USV) index the level of positive affect in the r
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1102-1112
ObjectivesInflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to explore the anti-inflammatory role of PTY-2r (extracted from Pueraria tuberosa), on streptozotocin (STZ)-induced DN rats.Met
Autor:
M. Leskiewicz, Barbara Korzeniak, Piotr Gruca, Beata Grygier, Katarzyna Curzytek, Danuta Wrona, Zofia Rogóż, Katarzyna Głombik, Bogusława Budziszewska, Michael Maes, Magdalena Regulska, Joanna Slusarczyk, Władysław Lasoń, Marta Kubera, Mariusz Papp, Adam Roman, Agnieszka Basta-Kaim
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 80:279-290
The effect of antidepressant drugs on tumor progress is very poorly recognized. The aim of the present study was to examine the effect of individual reactivity to stress and 24-day desipramine (DES) administration on the metastatic colonization of ad
Publikováno v:
Pharmacology Biochemistry and Behavior. 152:90-96
Preclinical psychopharmacology research needs novel behavioral indices and improved animal models for both sexes. The forced swim test (FST) is the most popular test for screening antidepressant potential. Sex differences in FST behaviors, such as im
Autor:
Thea P. Lillethorup, Anna Sophie Thue Hvilsom, Anne M. Landau, Peter Iversen, Doris J. Doudet, Gregers Wegener
Publikováno v:
Hvilsom, A S T, Lillethorup, T P, Iversen, P, Doudet, D J, Wegener, G & Landau, A M 2019, ' Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli ', European Neuropsychopharmacology, vol. 29, no. 4, pp. 493-500 . https://doi.org/10.1016/j.euroneuro.2019.02.009
Depression is a debilitating mental illness and two thirds of patients respond insufficiently to conventional antidepressants. Electroconvulsive therapy (ECT) remains the most effective treatment to alleviate drug-refractory depression, however the n
Autor:
Shouta M.M. Nakayama, Yusuke K. Kawai, Yoshinori Ikenaka, Marumi Ohno, Kensuke P. Watanabe, Mayumi Ishizuka, Yoshihiro Nishiyama
Publikováno v:
The Journal of Veterinary Medical Science
Rat cytochrome P450 (CYP) exhibits inter-strain differences, but their analysis has been scattered across studies under different conditions. To identify these strain differences in CYP more comprehensively, mRNA expression, protein expression and me
Publikováno v:
Alcoholism: Clinical and Experimental Research. 39:2022-2031
Background The P2X4 receptor (P2X4R) is thought to be involved in regulating alcohol-consuming behaviors, and ethanol (EtOH) has been reported to inhibit P2X4Rs. Ivermectin is an antiparasitic agent that acts as a positive allosteric modulator of the
Autor:
Braulio Rojas, Mario Herrera-Marschitz, David Vásquez, Diego Lagos, Mario Rivera-Meza, María Elena Quintanilla, Yedy Israel
Publikováno v:
Neuropharmacology. 146
A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alco
Autor:
Fabrizio Sanna, Francesco Sanna, Giovanna Piras, Maria Antonietta Piludu, Maria Giuseppa Corda, Alberto Fernández Teruel, Osvaldo Giorgi, Marianna Boi
Publikováno v:
Pharmacology, biochemistry, and behavior. 167
The Roman high- (RHA) and low-avoidance (RLA) outbred rat lines are selected for respectively rapid vs. poor acquisition of active avoidant behavior. Emotional reactivity appears to be the most prominent behavioral difference between the two lines, w