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Publikováno v:
Pharmacology Biochemistry and Behavior. 55:475-480
The present study investigated the effects of perinatal flumazenil (Ro 15-1788, a benzodiazepine receptor antagonist), given from gestational day 15 to the 14th day after giving birth, at two doses (3.5 and 6.3 mg/kg/ day) on the behavior of female R
Publikováno v:
Brain Research. 737:215-220
Ibogaine (IBO) is an indole alkaloid that is reported to facilitate drug abstinence in substance abusers. Despite considerable investigation, the mechanism of IBO action in vivo and its suitability as a treatment for drug addiction remains unclear. T
Autor:
Hironobu Kakuta, Nigishi Hotta, Tomohiro Hara, Keiko Naruse, Fumihiko Sakakibara, Hideo Fukasawa, Yoji Hamada, Nobuo Sakamoto, Koichi Mori, Jiro Nakamura, Naoki Koh
Publikováno v:
European Journal of Pharmacology. 313:201-209
To investigate the pathogenesis of diabetic neuropathy in non-insulin-dependent diabetes mellitus, Otsuka Long-Evans Tokushima Fatty rats, an animal model of non-insulin-dependent diabetes mellitus, and non-diabetic Long-Evans Tokushima Otsuka rats w
Publikováno v:
European Journal of Pharmacology. 313:221-227
Vascular function of Donryu rats fed on a normal or cholesterol-supplemented diet was examined in the isolated perfused mesenteric arterial bed and portally perfused liver. In mesenteric preparations, frequency-dependent vasoconstriction to electrica
Autor:
Paolo Madeddu, Maria Piera Demontis, Maria Vittoria Varoni, P. Pinna-Parpaglia, Nicola Glorioso, Vittorio Anania
Publikováno v:
Immunopharmacology. 33:301-304
We evaluated if a rat strain inbred for reduced urinary kallikrein excretion differs from normal-kallikrein Wistar rats regarding blood pressure in basal conditions and during alterations in sodium balance. Low-kallikrein rats showed greater systolic
Publikováno v:
Steroids. 61:317-322
The effect of endothelin-1 (ET-1) on cholesterol uptake by adrenal cortex was evaluated through several experimental approaches: infusion of ET-1 followed by measurement of endogenous cholesterol in excised adrenals; infusion of ET-1 followed by trit
Publikováno v:
Neuropharmacology. 35:497-501
Sexually receptive proestrous rats were infused bilaterally into the ventromedial nucleus of the hypothalamus (VMN) with 200 ng of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), 1000 or 2000 ng of 5-methoxy-3-(di-n-propylamino) chroman (5-MEO-D
Publikováno v:
Pharmacology Biochemistry and Behavior. 53:839-842
We studied the effect of the K+ channel opener cromakalim, which exhibits antihypertensive properties, on food intake in rats. Intraperitoneally injected cromakalim induced a dose-dependent (0.1, 0.5, and 1.0 mg/kg body wt.) reduction in food intake,
Publikováno v:
European Journal of Pharmacology. 297:71-76
We investigated the effect of hypercholesterolemia on the vascular reactivity of thoracic aortas isolated from hypertensive Dahl salt-sensitive (DS) rats. DS rats were fed on a low-sodium diet (control group), a low-sodium plus high-cholesterol diet
Publikováno v:
Pharmacology Biochemistry and Behavior. 53:33-40
Both the 5-HT2 antagonist, FG5606 (amperozide), and the mixed 5-HT1 agonist/5-HT2 antagonist, FG5893, attenuate significantly the volitional intake of alcohol in the cyanamide treated rat. The purpose of the present study was to investigate the effec