Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Joan J. Guinovart"'
Publikováno v:
The Journal of biological chemistry. 293(19)
Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as severe epilepsy. LD results from mutations in the gene encoding either the glycogen phosphatase laforin or the E3 ubiquitin ligase malin. Individuals wit
Autor:
Dolores Velasco, Ignacio Fita, Mireia Díaz-Lobo, Jaume Garcia-Amorós, Joan C. Ferrer, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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This journal is © The Royal Society of Chemistry 2015. Glycogen is a polymer of α-1,4- and α-1,6-linked glucose units that provides a readily available source of energy in living organisms. Glycogen synthase (GS) and glycogen phosphorylase (GP) ar
Autor:
Jordi Duran, Antonio L. Serrano, David Sebastián, Marta Vilaseca, Mar García-Rocha, Mitchell A. Sullivan, Felipe Slebe, Iliana López-Soldado, Francisco Vilaplana, Pura Muñoz-Cánoves, Joan J. Guinovart, Giorgia Testoni
Publikováno v:
Cell Metabolism
Recercat. Dipósit de la Recerca de Catalunya
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Recercat. Dipósit de la Recerca de Catalunya
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Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of glycogen in striated muscle. Further
Autor:
Maria Florencia Tevy, Oscar Yanes, Carlos Martínez-Pons, Jordi Duran, Marco Milán, Antoni Beltran, Christopher Sinadinos, Joan J. Guinovart, Isabel Saez
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:945-955
Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as
Autor:
Cristina Saez-Lopez, Marta García-Ramírez, Ángela M. Valverde, Mar García-Rocha, Cristina Hernández, Rafael Simó, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Liver and muscle glycogen content is reduced in diabetic patients but there is no information on the effect of diabetes on the glycogen content in the retinal pigment epithelium (RPE). The main aim of the study was to compare the glycogen content in
Autor:
Ignacio Fita, Alda Lisa Concia, Mireia Díaz-Lobo, Pere Clapés, Joan C. Ferrer, Livia Gómez, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Glycogen synthase (GS) and glycogen phosphorylase (GP) are the key enzymes that control, respectively, the synthesis and degradation of glycogen, a multi-branched glucose polymer that serves as a form of energy storage in bacteria, fungi and animals.
Publikováno v:
Journal of Biological Chemistry. 284:6370-6378
Eukaryotic glycogen synthase activity is regulated by reversible phosphorylation at multiple sites. Of the two GS isoforms found in mammals, the muscle enzyme (muscle glycogen synthase) has received more attention and the relative importance of every
Autor:
Frank Sicheri, Roger W. Hunter, Xiaojing Tang, Mike Tyers, Andrew Judd, Mar García-Rocha, Joan J. Guinovart, Maria Deak, Elton Zeqiraj, Alexander von Wilamowitz-Moellendorff, Kei Sakamoto, Igor Kurinov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(28)
Glycogen is a primary form of energy storage in eukaryotes that is essential for glucose homeostasis. The glycogen polymer is synthesized from glucose through the cooperative action of glycogen synthase (GS), glycogenin (GN), and glycogen branching e
Publikováno v:
Journal of Biological Chemistry. 276:23858-23866
We used metabolic control analysis to determine the flux control coefficient of phosphorylase on glycogen synthesis in hepatocytes by titration with a specific phosphorylase inhibitor (CP-91149) or by expression of muscle phosphorylase using recombin
Publikováno v:
Biochemical Journal. 351:811-816
We have used recombinant adenoviruses (AdCMV-RLGS and AdCMV-GK) to overexpress the liver isoforms of glycogen synthase (GS) and glucokinase (GK) in primary cultured rat hepatocytes. Glucose activated overexpressed GS in a dose-dependent manner and ca