Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joan J. Guinovart"'
Publikováno v:
Frontiers in Endocrinology. 13
Increased liver glycogen content has been shown to reduce food intake, attenuate obesity, and improve glucose tolerance in a mouse model of high-fat diet (HFD)-induced obesity. Here we studied the contribution of liver glycogen to the regulation of o
Publikováno v:
Diabetologia. 60:1076-1083
Liver glycogen plays a key role in regulating food intake and blood glucose. Mice that accumulate large amounts of this polysaccharide in the liver are protected from high-fat diet (HFD)-induced obesity by reduced food intake. Furthermore, these anim
Autor:
Marc Zuend, Jordi Duran, Bruno Weber, Aiman S. Saab, Ladina Hösli, Kim David Ferrari, Jillian L. Stobart, Matthias T. Wyss, Joan J. Guinovart, L. Felipe Barros, Zoe J Looser
Publikováno v:
Nature metabolism. 2(2)
It has been suggested that, in states of arousal, release of noradrenaline and β-adrenergic signalling affect long-term memory formation by stimulating astrocytic lactate production from glycogen. However, the temporal relationship between cortical
Autor:
Felipe Slebe, Mar García-Rocha, Rosa Gasa, Jordi Duran, Ramon Gomis, Joan J. Guinovart, Joan Mir-Coll
Publikováno v:
Diabetologia. 59:1012-1020
Glycogen accumulation occurs in beta cells of diabetic patients and has been proposed to partly mediate glucotoxicity-induced beta cell dysfunction. However, the role of glycogen metabolism in beta cell function and its contribution to diabetes patho
Autor:
Delia Zafra, Joan J. Guinovart, Jordi Duran, Iliana López-Soldado, Joaquim Calbó, Anna Adrover
Publikováno v:
Diabetes. 64:796-807
We generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTGOE), which results in an increase in liver glycogen. When fed a high-fat diet (HFD), these animals reduced their food intake. The resulting effect was a lower bod
Autor:
Cristina Saez-Lopez, Marta García-Ramírez, Ángela M. Valverde, Mar García-Rocha, Cristina Hernández, Rafael Simó, Joan J. Guinovart
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Liver and muscle glycogen content is reduced in diabetic patients but there is no information on the effect of diabetes on the glycogen content in the retinal pigment epithelium (RPE). The main aim of the study was to compare the glycogen content in
Autor:
Ainhoa Garcia, Sandra A. Rebuffat, Delia Zafra, Deborah J. Burks, Rosa Gasa, Susana G. Kalko, Joana Moitinho Oliveira, Joan J. Guinovart, Ramon Gomis
Publikováno v:
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 306 (1), pp.E36-E47. ⟨10.1152/ajpendo.00409.2013⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 306 (1), pp.E36-E47. ⟨10.1152/ajpendo.00409.2013⟩
Pancreatic β-cells play a central role in type 2 diabetes (T2D) development, which is characterized by the progressive decline of the functional β-cell mass that is associated mainly with increased β-cell apoptosis. Thus, understanding how to enha
Publikováno v:
Diabetologia. 54:2639-2648
Glycogen deposition is impaired in diabetes, thus contributing to the development of hyperglycaemia. Several glucose-lowering strategies have attempted to increase liver glycogen deposition by modulating targets, which eventually trigger the activati
Autor:
Joan Ballester, Teresa Rigau, Jorge Domínguez, Joan E. Rodríguez-Gil, Meritxell Sensat, Joan J. Guinovart, M. Carmen Muñoz
Publikováno v:
Journal of Andrology. 26:706-715
Oral administration of sodium tungstate to adult male streptozotocin-diabetic rats for 3 months normalized serum levels of glucose, insulin, luteinizing hormone, and follicle-stimulating hormone. These effects were accompanied by an increase in repro
Autor:
Mariano Domingo, N. Prats, Ramon Gomis, Roger R. Gomis, Albert Barberà, Joan E. Rodríguez-Gil, Joan J. Guinovart
Publikováno v:
Diabetologia. 44:507-513
Aims/hypothesis. Recent studies have shown the anti diabetic effects of oral sodium tungstate treatment in several animal models of diabetes based on short-term experiments. In this study, we examined the effectiveness of long-term tungstate treatmen