Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Smith, David A."'
Autor:
Smith, David A., Fernandez-Antunez, Carlota, Magri, Andrea, Bowden, Rory, Chaturvedi, Nimisha, Fellay, Jacques, McLauchlan, John, Foster, Graham R., Irving, William L., Simmonds, Peter, Pedergnana, Vincent, Ramirez, Santseharay, Bukh, Jens, Barnes, Eleanor, Ansari, M. Azim, Ball, Jonathan, Brainard, Diana, Burgess, Gary, Cooke, Graham, Dillon, John, Gore, Charles, Guha, Neil, Halford, Rachel, Herath, Cham, Holmes, Chris, Howe, Anita, Hudson, Emma, Irving, William, Khakoo, Salim, Klenerman, Paul, Koletzki, Diana, Martin, Natasha, Massetto, Benedetta, Mbisa, Tamyo, McHutchison, John, McKeating, Jane, Miners, Alec, Murray, Andrea, Shaw, Peter, Spencer, Chris C. A., Targett-Adams, Paul, Thomson, Emma, Vickerman, Peter, Zitzmann, Nicole
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
STOP-HCV Consortium 2021, ' Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure ', Nature Communications, vol. 12, no. 1, 6105 . https://doi.org/10.1038/s41467-021-25649-6
Nature Communications, 2021, 12 (1), pp.6105. ⟨10.1038/s41467-021-25649-6⟩
Nature communications, vol. 12, no. 1, pp. 6105
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
STOP-HCV Consortium 2021, ' Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure ', Nature Communications, vol. 12, no. 1, 6105 . https://doi.org/10.1038/s41467-021-25649-6
Nature Communications, 2021, 12 (1), pp.6105. ⟨10.1038/s41467-021-25649-6⟩
Nature communications, vol. 12, no. 1, pp. 6105
Sofosbuvir is a common therapy in hepatitis C virus infection, which targets the NS5B polymerase. Here, Smith et al. analyze the association between whole genome HCV polymorphisms and sofosbuvir treatment failure and identify three common polymorphis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9cf99c929fe18ff1ccaeb9a812b730
Autor:
Smith David, James G. Boyd, Gaurav Saini, Matthew R. Linford, Olgica Trenchevska, Loren J. Howell, Varun Jain
Publikováno v:
Langmuir. 34:11925-11932
Silicon oxide substrates underwent gas-phase functionalization with various aminosilanes, and the resulting surfaces were evaluated for their suitability as a solid support for solid phase peptide synthesis (SPPS). APTES (3-aminopropyltriethoxysilane
Autor:
Klamer, Zachary, Staal, Ben, Prudden, Anthony R, Liu, Lin, Smith, David F, Boons, Geert-Jan, Haab, Brian, Afd Chemical Biology and Drug Discovery, Sub Algemeen Scheikunde, Chemical Biology and Drug Discovery
Publikováno v:
Analytical Chemistry
Analytical Chemistry, 89(22), 12342. American Chemical Society
Analytical Chemistry, 89(22), 12342. American Chemical Society
Knowledge of lectin and glycosidase specificities is fundamental to the study of glycobiology. The primary specificities of such molecules can be uncovered using well-established tools, but the complex details of their specificities are difficult to
Autor:
Greggio, Elisa, Leong, Su Ling, Hinds, Mark G., Connor, Andrea R., Smith, David, Illes-Toth, Eva, Pham, Chi L. L., Barnham, Kevin J., Cappai, Roberto
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 2, p e0116497 (2015)
PLoS ONE, Vol 10, Iss 2, p e0116497 (2015)
α-synuclein (α-syn) is a major component of the intracellular inclusions called Lewy bodies, which are a key pathological feature in the brains of Parkinson's disease patients. The neurotransmitter dopamine (DA) inhibits the fibrillisation of α-sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ea5858d4eebad0ebefabd701a23caf
https://shura.shu.ac.uk/9508/1/Smith_N_terminal_residues_43_to_60.pdf
https://shura.shu.ac.uk/9508/1/Smith_N_terminal_residues_43_to_60.pdf
Publikováno v:
Neuropharmacology. 44:516-523
The ability of the substance P (NK(1) receptor) antagonist (SPA) L-760735 to inhibit conditioned fear was assessed in gerbils using a four plate apparatus. Animals that had been treated with diazepam (3 mg/kg) or L-760735 (3 mg/kg) 30 min before a 3
Autor:
Karen L Locker, Smith David W, Timothy Harrison, Christopher John Swain, Nadia M.J. Rupniak, Michael J Cumberbatch, Rachel K. Conley, Karen A. Maubach, Louise Hewson, David J. Williamson, Michael Rigby, G Mason, Ruth O'Donnell
Publikováno v:
The Journal of Neuroscience. 22:7730-7736
Substance P receptor [neurokinin 1 (NK(1))] antagonists (SPAs) represent a novel mechanistic approach to antidepressant therapy with comparable clinical efficacy to selective serotonin reuptake inhibitors (SSRIs). Because SSRIs are thought to exert t
Autor:
R. J. Mayer, Steven R. Katchur, L. A. Marshall, Smith David Glynn, A. E. Marolewski, P. L. Flamberg, Andrew Faller, Brian Bolognese
Publikováno v:
Inflammation Research. 51:85-90
CD23 (low affinity IgE receptor, FcepsilonRII) is expressed as a Type II extracellular protein on a variety of cells such as B cells, monocytes and macrophages and is cleaved from the cell surface to generate several distinct fragments. The expressio
Autor:
Aled E. Murphy, Sean Wright, Craig T. Ryan, Alton B. Horsfall, D. T. Clark, Robert A. R. Young, Smith David E A, E.P. Ramsay, Robin. F. Thompson
Publikováno v:
MRS Proceedings. 1693
We present the characteristics of a high temperature CMOS integrated circuit process based on 4H silicon carbide designed to operate at temperatures beyond 300°C. N-channel and P-channel transistor characteristics at room and elevated temperatures a
Autor:
Angela Bridges, Benjamin D. Bax, Ainsley A. Culbert, Ceri J. Lewis, Gary Pettman, Smith David Glynn, Paul S. Carter, Murray J. B. Brown, Angela R. Guy, Alastair D. Reith, Chris Mannix, Robert Tanner
Publikováno v:
Structure. 9:1143-1152
Background: Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognizing and phosphorylating the first serine in the sequence motif SxxxS(P) (wher
Autor:
Ruth O'Donnell, Smith David W, Susan Boyce, T. Harrison, Nadia M.J. Rupniak, Michael Rigby, Louise Hewson, Emma J. Carlson
Publikováno v:
Neuropharmacology. 41:130-137
The involvement of the basolateral amygdala in mediating the inhibition of neonatal vocalisation by substance P (NK(1) receptor) antagonists was examined. These studies determined whether the time course for separation-induced vocalisations in guinea