Zobrazeno 1 - 10
of 86
pro vyhledávání: '"133"'
Autor:
Suzan Wetzels, Erik A.L. Biessen, Erwin Wijnands, Mitchell Bijnen, Casper G. Schalkwijk, Kristiaan Wouters
Publikováno v:
Journal of visualized experiment. Journal of Visualized Experiments
ISSUE=133;ISSN=1940-087X;TITLE=Journal of visualized experiment
Journal of Visualized Experiments : JoVE
ISSUE=133;ISSN=1940-087X;TITLE=Journal of visualized experiment
Journal of Visualized Experiments : JoVE
Infiltration of immune cells in the subcutaneous and visceral adipose tissue (AT) deposits leads to a low-grade inflammation contributing to the development of obesity-associated complications such as type 2 diabetes. To quantitatively and qualitativ
Autor:
Jacques M.G.J. Duijs, Dania Reiche, Jerzy Adamski, Ton J. Rabelink, Cornelia Prehn, Jennifer Veth, Roel Bijkerk, Marina A. Aleksinskaya, Jo G. R. De Mey, Bettina Husen, Anton Jan van Zonneveld
Publikováno v:
Clinical Science, 133(2), 239-252. Portland Press Ltd.
Bijkerk, R, Aleksinskaya, M A, Duijs, J M G J, Veth, J, Husen, B, Reiche, D, Prehn, C, Adamski, J, Rabelink, T J, De Mey, J G R & van Zonneveld, A J 2019, ' Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation ', Clinical Science, vol. 133, no. 2, pp. 239-252 . https://doi.org/10.1042/CS20180882
Bijkerk, R, Aleksinskaya, M A, Duijs, J M G J, Veth, J, Husen, B, Reiche, D, Prehn, C, Adamski, J, Rabelink, T J, De Mey, J G R & van Zonneveld, A J 2019, ' Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation ', Clinical Science, vol. 133, no. 2, pp. 239-252 . https://doi.org/10.1042/CS20180882
Kidney fibrosis is the common pathophysiological mechanism in end-stage renal disease characterized by excessive accumulation of myofibroblast-derived extracellular matrix. Natriuretic peptides have been demonstrated to have cyclic guanosine monophos
Autor:
Achim Schmidtko, Gerd Geisslinger, Wei Gao, Ellen Niederberger, Charlotte von Gall, Corina Ehnert, Irmgard Tegeder, Laura Popp, Horst-Werner Korf, Ovidiu Coste
Publikováno v:
Biochemical and Biophysical Research Communications. 362:75-80
Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord. CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important. We
Autor:
Tiffany Ciszewski, David J. Tollerud, Ray Yeager, James McCracken, Atul R. Chugh, Stephen G. Wagner, Ihab Hamzeh, Natasha DeJarnett, Zhengzhi Xie, Deirdre Higdon, Kenneth S. Ramos, Timothy E. O'Toole, John Myers, Sanjay K. Srivastava, Brad Wyatt, Aruni Bhatnagar, Wes Abplanalp, Sumanth D. Prabhu, Carrie Becher, Daniel W. Riggs, Daniel J. Conklin, Shesh N. Rai, Andrew P. DeFilippis
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Acrolein is a reactive aldehyde present in high amounts in coal, wood, paper, and tobacco smoke. It is also generated endogenously by lipid peroxidation and the oxidation of amino acids by myeloperoxidase. In animals, acrolein exposure is
Autor:
Yuki Ishibashi, Yusuke Shinoda, Koichi Okajima, Takahiro Goto, Sakae Tanaka, Toru Akiyama, Liuzhe Zhang, Toshihide Hirai, Hiroshi Kobayashi, Takahiro Ohki, Ryoko Sawada, Masachika Ikegami, Tomotake Okuma
Publikováno v:
Journal of Orthopaedic Science. 27:222-228
Eribulin is a tubulin and microtubule-targeting drug that has clinical benefit in overall survival (OS) for patients with advanced soft tissue sarcoma. Eribulin's efficacy has been confirmed in several clinical trials, although no clinically useful b
Publikováno v:
International Journal of Nanomedicine
Purpose Psoriasis is an inflammatory skin disease, where keratinocytes play pivotal roles in its pathogenesis. We prepared Celastrol Noisome hydrogel (Cel Nio gel) for the treatment of psoriasis and aimed to study its target site as well as the mecha
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 238(10)
The purpose of this study was to investigate the anti-inflammatory and antiobesity effect of combinational mulberry leaf extract (MLE) and mulberry fruit extract (MFE) in a high-fat (HF) diet-induced obese mice. Mice were fed a control diet or a HF d
Autor:
Yinsheng Qiu, Shulin Fu, Ling Guo, Sanling Zuo, Chien-An Andy Hu, Yulan Liu, Dan Zhang, Qingyan Meng, Chun Ye, Jing He
Publikováno v:
DNA and Cell Biology. 40:776-790
Glaesserella parasuis causes porcine Glasser's disease and lipopolysaccharide (LPS) induces acute inflammation and pathological damage. Baicalin has antioxidant, antimicrobial, and anti-inflammatory functions. Long noncoding RNAs (lncRNAs) play key r
Autor:
Jing Wang, Yunbing Wang, Guosheng Fu, Ke-feng Ren, Dan-ni Huang, Jian Ji, Hongye Hao, Wei-Pin Huang, Hong-Lin Qian, Shengyu Chen
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 6, Iss 12, Pp 4686-4696 (2021)
Bioactive Materials, Vol 6, Iss 12, Pp 4686-4696 (2021)
The in-stent restenosis (IRS) after the percutaneous coronary intervention contributes to the major treatment failure of stent implantation. MicroRNAs have been revealed as powerful gene medicine to regulate endothelial cells (EC) and smooth muscle c
Autor:
Lene Terslev, Pentti Järvinen, Marjatta Leirisalo-Repo, Michael Ziegelasch, B. Agular, Hilde Berner Hammer, Inger Marie Jensen Hansen
Publikováno v:
Hammer, H B, Hansen, I M J, Järvinen, P, Leirisalo-Repo, M, Ziegelasch, M, Agular, B & Terslev, L 2021, ' Major reduction of ultrasound-detected synovitis during subcutaneous tocilizumab treatment : results from a multicentre 24 week study of patients with rheumatoid arthritis ', Scandinavian Journal of Rheumatology, vol. 50, no. 4, pp. 262-270 . https://doi.org/10.1080/03009742.2020.1845394
Objective: Few studies have investigated the efficacy of subcutaneous tocilizumab (TCZ-SC) on ultrasound-detected inflammation. This study aimed to explore the clinical efficacy of TCZ-SC treatment in rheumatoid arthritis (RA) patients and to evaluat