Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Joan J. Guinovart"'
Autor:
Patrícia Coelho, Pranvera Sadiku, Alex von Kriegsheim, Leila Reyes, David H. Dockrell, Robert Grecian, Jordi Duran, Christopher J Graham, Simone Arienti, Abel Acosta-Sanchez, Veronica M. Dardé, Privjyot Jheeta, Ananda S. Mirchandani, Gordon G. Paterson, A. A. Roger Thompson, David Sammut, Tyler Morrison, Martin A. Bewley, Ailing Zhang, Joseph A Willson, Massimiliano Mazzone, Kenneth Baillie, Moira K. B. Whyte, Tobias Griessler, Sarah R. Walmsley, Emily R. Watts, Peter Carmeliet, Jessie-May Morgan, Eilise M. Ryan, John P. Thomson, Manuel A. Sanchez Garcia, Bart Ghesquière, Joan J. Guinovart, Richard R. Meehan, Gio Rodriguez-Blanco, Jason M. Young
Publikováno v:
Sadiku, P, Willson, J A, Ryan, E M, Sammut, D, Coelho, P, Watts, E R, Grecian, R, Young, J M, Bewley, M, Arienti, S, Mirchandani, A S, Sanchez Garcia, M A, Morrison, T, Zhang, A, Reyes, L, Griessler, T, Jheeta, P, Paterson, G G, Graham, C J, Thompson, J P, Baillie, K, Thompson, A A R, Morgan, J-M, Acosta-Sanchez, A, Dardé, V M, Duran, J, Guinovart, J J, Rodriguez-Blanco, G, Von Kriegsheim, A, Meehan, R R, Mazzone, M, Dockrell, D H, Ghesquiere, B, Carmeliet, P, Whyte, M K B & Walmsley, S R 2021, ' Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis ', Cell Metabolism, vol. 33, no. 2, pp. 411-423.e4 . https://doi.org/10.1016/j.cmet.2020.11.016
Cell Metabolism
Cell Metabolism
Summary Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cad74cc910e5a97db33fae4b7012689
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
https://eprints.whiterose.ac.uk/169130/1/1-s2.0-S1550413120306513-main.pdf
Autor:
Maria Florencia Tevy, Oscar Yanes, Carlos Martínez-Pons, Jordi Duran, Marco Milán, Antoni Beltran, Christopher Sinadinos, Joan J. Guinovart, Isabel Saez
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:945-955
Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as
Publikováno v:
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
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[EN] Both radiotherapy and most effective chemotherapeutic agents induce different types of DNA damage. Here we show that tungstate modulates cell response to DNA damaging agents. Cells treated with tungstate were more sensitive to etoposide, phleomy
Autor:
Rodrigo, Maldonado, Héctor, Mancilla, Franz, Villarroel-Espíndola, Felipe, Slebe, Juan Carlos, Slebe, Raúl, Méndez, Joan J, Guinovart, Ilona I, Concha
Publikováno v:
Journal of cellular biochemistry. 117(11)
Sertoli cell metabolism actively maintains the nutritional needs of germ cells. It has been described that after glucose incorporation in Sertoli cells, less than 1% is converted to glycogen suggesting low levels of glycogen synthase activity. Phosph
Autor:
Ilona I. Concha, Alejandro J. Yáñez, Joan J. Guinovart, Juan C. Slebe, Manuel Grez, Doris E. Sáez, Mar García-Rocha, Cristian A. Droppelmann, Joel L. Asenjo
Publikováno v:
The Biochemical journal. 472(2)
Understanding how glucose metabolism is finely regulated at molecular and cellular levels in the liver is critical for knowing its relationship to related pathologies, such as diabetes. In order to gain insight into the regulation of glucose metaboli
Autor:
Frank Sicheri, Roger W. Hunter, Xiaojing Tang, Mike Tyers, Andrew Judd, Mar García-Rocha, Joan J. Guinovart, Maria Deak, Elton Zeqiraj, Alexander von Wilamowitz-Moellendorff, Kei Sakamoto, Igor Kurinov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(28)
Glycogen is a primary form of energy storage in eukaryotes that is essential for glucose homeostasis. The glycogen polymer is synthesized from glucose through the cooperative action of glycogen synthase (GS), glycogenin (GN), and glycogen branching e
The Role of the Regulatory Protein of Glucokinase in the Glucose Sensory Mechanism of the Hepatocyte
Publikováno v:
Journal of Biological Chemistry. 275:10597-10603
Glucokinase has a very high flux control coefficient (greater than unity) on glycogen synthesis from glucose in hepatocytes (Agius et al., J. Biol. Chem. 271, 30479-30486, 1996). Hepatic glucokinase is inhibited by a 68-kDa glucokinase regulatory pro
Autor:
Joan J. Guinovart, Eulàlia Montell, Christopher B. Newgard, Anna M. Gómez-Foix, Susanna Baqué
Publikováno v:
Diabetes. 47:1392-1398
Insulin resistance, as is found in skeletal muscle of individuals with obesity and NIDDM, appears to involve a reduced capacity of the hormone to stimulate glucose uptake and/or phosphorylation. The glucose phosphorylation step, as catalyzed by hexok
Autor:
Anna M. Gómez-Foix, Antonio Zorzano, Joan J. Guinovart, Susanna Baqué, Eulàlia Montell, Marta Camps
Publikováno v:
Diabetes. 47:1185-1192
Skeletal muscle glucose utilization, a major factor in the control of whole-body glucose tolerance, is modulated in accordance with the muscle metabolic demand. For instance, it is increased in chronic contraction or exercise training in association
Publikováno v:
FEBS Letters. 415:249-252
We have studied the intracellular localization of muscular glycogen synthase by fusing the green fluorescent protein (GFP) of the jelly-fish Aequorea victoria to the N-terminus of human muscle glycogen synthase (HMGS), and expressing the chimeric pro