Zobrazeno 1 - 10
of 813
pro vyhledávání: '"11"'
Autor:
Xiling Wu, Xing Ji, Lanfang Tang, Ximei Wu, Hongyi Yao, Musaddique Hussain, Meiping Lu, Junsong Wu, Jirong Wang, Chengyun Xu
Publikováno v:
FASEB J
Src homology domain 2–containing protein tyrosine phosphatase 2 (SHP2) participates in multiple cell functions including cell shape, movement, and differentiation. Therefore, we investigated the potential role of SHP2 in eosinophil recruitment into
Autor:
Hirofumi Yamagishi, Yasuhiro Mochizuki, Yohei Kawano, Takao Hamakubo, Hajime Karasuyama, Yoshiyuki Minegishi, Kazushige Obata, Shingo Sato, Tsukasa Ugajin
Publikováno v:
Biochemical and Biophysical Research Communications. 415:709-713
Mouse mast cell protease 11 (mMCP-11) is the most recently identified member of the mouse mast cell tryptase family. This tryptase is preferentially produced by basophils in contrast to other members that are expressed by mast cells but not basophils
Publikováno v:
Biochemical and biophysical research communications. 336(1)
Induction of an immune response to amyloid beta-protein (Abeta) is effective in treating animal models of Alzheimer's disease. Human clinical trials of vaccination with synthetic Abeta (AN1792), however, were halted due to brain inflammation, presuma
Autor:
John Savill, Graham Thomas, Karen E. Chapman, James S. Gilmour, Hayley J. Harris, Agnes Coutinho, Tak Yung Man, Michael Clay, Jonathan R. Seckl, Jean-François Cailhier, John J. Mullins
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 176(12)
Glucocorticoids promote macrophage phagocytosis of leukocytes undergoing apoptosis. Prereceptor metabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenases (11β-HSDs) modulates cellular steroid action. 11β-HSD type 1 amplifies intracellular
Publikováno v:
Fish & Shellfish Immunology. 99:44-51
Interleukin 11 (IL-11) is a secretory cytokine with pleotropic properties, including anti-inflammatory and anti-apoptotic functions. This study aimed to functionally characterize a teleostean IL-11a ortholog from redlip mullet (LhIL-11a) through bioi
Autor:
Irvin Jose, Ashley Mansell, Liana Mackiewicz, Boris Reljic, Richard S. Hotchkiss, Hamsa Puthalakath, Joseph Menassa, Christina Nedeva, Pierre Faou, Marc Pellegrini, Marcel Doerflinger
Publikováno v:
The FEBS Journal. 288:1809-1821
Sepsis remains to be a major contributor to mortality in ICUs, and immune suppression caused by immune cell apoptosis determines the overall patient survival. However, diagnosis of sepsis-induced lymphopenia remains problematic with no accurate progn
Autor:
Jasper J. van Gemst, Nathalie J. H. G. Passmann, Angelique L. W. M. M. Rops, Toin H. van Kuppevelt, Jo H. Berden, Markus A. Loeven, Ton J. Rabelink, Bart Smeets, Johan van der Vlag
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261722 (2021)
PLoS One, 16
PLoS One, 16, 12
PLoS ONE, 16(12). PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS One, 16
PLoS One, 16, 12
PLoS ONE, 16(12). PUBLIC LIBRARY SCIENCE
PLoS ONE
Contains fulltext : 244767.pdf (Publisher’s version ) (Open Access) Glomerulonephritis is an acquired serious glomerular disease, which involves the interplay of many factors such as cytokines, chemokines, inflammatory cells, and heparan sulfate (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef59d333405d24298bccb7d77a8e1ea
https://hdl.handle.net/1887/3277734
https://hdl.handle.net/1887/3277734
Autor:
Kenton P. Arkill, Matthew Golding, Astrid F. Nottebaum, Monja Stein, Tamara Girbl, Charlotte Owen-Woods, Bin Ma, Régis Joulia, Anna Barkaway, Loïc Rolas, Mathieu-Benoit Voisin, Sussan Nourshargh, David O. Bates, Dietmar Vestweber
Publikováno v:
The Journal of Clinical Investigation
Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular per
Autor:
Kian Fan Chung, Chantal Donovan, Martha R. Tyas, Graeme Milligan, Philip M. Hansbro, Elisa Alvarez-Curto, Latifa Chachi, Davinder Kaur, Coen Wiegman, Zhaoyang Dong, Abdulrahman Ghali M. Alharbi, Andrew B. Tobin, Trond Ulven, Christopher E. Brightling, Eloise Euston, Richard Kim, Rudi Prihandoko, Jack G. Lowe
Publikováno v:
Prihandoko, R, Kaur, D, Wiegman, C H, Alvarez-Curto, E, Donovan, C, Chachi, L, Ulven, T, Tyas, M R, Euston, E, Dong, Z, Alharbi, A G M, Kim, R Y, Lowe, J G, Hansbro, P M, Chung, K F, Brightling, C E, Milligan, G & Tobin, A B 2020, ' Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 ', Science Translational Medicine, vol. 12, no. 557, 9009 . https://doi.org/10.1126/scitranslmed.aaw9009
Increased prevalence of inflammatory airway diseases including asthma and chronic obstructive pulmonary disease (COPD) together with a significant number of patients being inadequately controlled by current frontline treatments means that there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ec3c16cfc0be37561e10eb3daf21bc
https://eprints.gla.ac.uk/225258/1/225258.pdf
https://eprints.gla.ac.uk/225258/1/225258.pdf
Autor:
Angelique L.W.M.M. Rops, M.A.H. Bakker-van Bebber, Luuk B. Hilbrands, Martin Götte, M. Kouwenberg, J. van der Vlag, L.E. Diepeveen
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0230835 (2020)
PLoS One, 15, 7
PLoS One, 15
PLoS ONE
PLoS One, 15, 7
PLoS One, 15
PLoS ONE
Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models. Sdc-1 expression has been reported on dendritic cells (DC) an