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Autor:
Matthew D. McGraw, Min Yee, So-Young Kim, Andrew M. Dylag, B. Paige Lawrence, Michael A. O’Reilly
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(5)
Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop following exposure to toxic chemicals as well as respiratory tract infections. BO development is strongly associated with diacetyl (DA) inhalation exposures
Autor:
Andrew Pham, Kim Dore
Publikováno v:
Semin Cell Dev Biol
A significant proportion of brains with Alzheimer's disease pathology are obtained from patients that were cognitively normal, suggesting that differences within the brains of these individuals made them resilient to the disease. Here, we describe re
Autor:
Shang Wang, Irina V Larina
Publikováno v:
Reproduction
In brief In vivo imaging of gametes and embryos in the oviduct enables new studies of the native processes that lead to fertilization and pregnancy. This review article discusses recent advancements in the in vivo imaging methods and insights which c
Autor:
Conor McClenaghan, Colin G. Nichols
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Kir6.1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a wide range of tissues. Extensive study has implicated roles of these channel subunits in diverse physiological functions. Together they generate the predominant KA
Publikováno v:
Stem cells and development. 31(17-18)
Lineage-specific differentiation of human-induced pluripotent stem cells (hiPSCs) into cardiomyocytes (CMs) offers a patient-specific model to dissect development and disease pathogenesis in a dish. However, challenges exist with this model system, s
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the KCNJ16 gene) hav
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(3)
The translational value of high-throughput toxicity testing will depend on pharmacokinetic validation. Yet, popular in vitro airway epithelia models were optimized for structure and mucociliary function without considering the bioactivation or detoxi
Autor:
Elissa M. Hult, Stephen J. Gurczynski, David N. O’Dwyer, Rachel L. Zemans, Andrew Rasky, Yizhuo Wang, Susan Murray, Howard C. Crawford, Bethany B. Moore
Publikováno v:
American journal of respiratory cell and molecular biology. 67(6)
Idiopathic pulmonary fibrosis (IPF) is a poorly understood, progressive lethal lung disease with no known cure. In addition to alveolar epithelial cell (AEC) injury and excessive deposition of extracellular matrix proteins, chronic inflammation is a
Publikováno v:
Cell cycle (Georgetown, Tex.). 21(24)
Hepatocellular carcinoma (HCC) is one of the most common cancers and has continued to increase in incidence worldwide. Moreover, the involvement of microRNAs (miRs) has been reported in the development and progression of HCC. Here, we investigated th
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(2)
Though survival rates for preterm infants are improving, the incidence of chronic lung disease of infancy, or bronchopulmonary dysplasia (BPD), remains high. Histologically, BPD is characterized by larger and fewer alveoli. Hypoxia-inducible factors