Zobrazeno 61 - 70
of 162 825
pro vyhledávání: ''
Autor:
Thomas S. McCormick, Pushpa Pandiyan
Publikováno v:
Journal of Investigative Dermatology. 142:867-875
This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and how they are involved in cutaneous pathogenic responses. It will also discuss cutaneous dysbiosis and FOXP3+ regulatory T cells in the context
Autor:
J. Oborski, Esther Kurth, Earl Mcdonald, Florencia Rago, Audrey Kauffmann, Jessi Ambrose, Zainab Jagani, Kathleen Sprouffske, Lindsey Rodrigues, Peter Aspesi, Julie T. Chen, Felipa A. Mapa, Tinya Abrams, Hyo-eun C. Bhang, David A. Ruddy, GiNell Elliott, M. Bonney
Publikováno v:
Molecular Cancer Research. 20:361-372
Various subunits of mammalian SWI/SNF chromatin remodeling complexes display loss-of-function mutations characteristic of tumor suppressors in different cancers, but an additional role for SWI/SNF supporting cell survival in distinct cancer contexts
Autor:
Shantibhusan Senapati, Amlan Priyadarshee Mohapatra, Voddu Suresh, Biswajit Das, Deepti Parida, Aliva Prity Minz, Debasish Mohapatra, Rajeeb K. Swain, Usharani Nayak
Publikováno v:
Laboratory Investigation. 102:298-311
Pancreatic cancer (PC) is highly resistant to chemo and radiotherapy. Radiation-induced fibrosis (RIF) is a major cause of clinical concern for various malignancies, including PC. In this study, we aimed to evaluate the radiosensitizing and anti-RIF
Autor:
Yufeng Li, Chi Kwan Tsang, Xiaoxiong Huang, Xueyi Wen, Dan Lu, Yang Zhenguo, Jiankun Zang, Cheng Huang, Keshen Li, Wenlin Liu, Anding Xu, Ze’an Weng
Publikováno v:
Molecular Therapy. 30:1275-1287
Blood-brain barrier (BBB) damage can be a result of central nervous system (CNS) diseases and may be a cause of CNS deterioration. However, there are still many unknowns regarding effective and targeted therapies for maintaining BBB integrity during
Publikováno v:
Cytotherapy. 24:225-234
Background aims Several studies have shown the efficacy of mesenchymal stem cell (MSC) therapy for lower extremity vascular disease (LEVD) in diabetic patients, but the results are not consistent. Therefore, the authors conducted a meta-analysis of r
Autor:
Monique Verhaegen, Arul M. Chinnaiyan, Julia VanGoor, Drew Pratt, Doris Mangelberger, Xuhong Cao, Fengyun Su, Andrzej A. Dlugosz, Jean C. Tien, Josh N. Vo, Jae Eun Choi, Paul W. Harms, Vincent T. Ma, Saravana M. Dhanasekaran
Publikováno v:
J Invest Dermatol
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that is classified as Merkel cell polyomavirus (MCPyV)-positive or virus-negative. Epigenetic changes, such as DNA methylation, can alter gene expression and influence ca
Publikováno v:
Current Protein & Peptide Science. 23:158-165
Abstract: Cancer is fundamentally a disease of perturbed genes. Although many mutations can be marked in the genome of cancer or a transformed cell, the initiation and progression are driven by only a few mutational events, viz., driver mutations tha
Autor:
Atsuko Shono, Coenraad K van Kalken, Peter J. van der Spek, Eric P Krenning, Toru Kotani, Djo Hasan
Publikováno v:
Purinergic Signalling
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Hyperinflammation plays an important role in severe and critical COVID-19. Using inconsistent criteria, many researchers define hyperinflammation as a form of very severe inflammation with cytokine storm. Therefore, COVID-19 patients are treated with
Publikováno v:
Journal of Investigative Dermatology. 142:823-833
Dysregulation in the phenotype and function of neutrophils may play important roles in the initiation and perpetuation of autoimmune responses, including conditions affecting the skin. Neutrophils can have local and systemic effects on innate and ada
Autor:
I-Wen Wang, Keith L. March, Mark W. Turrentine, Jianyun Liu, Susan R. Scott, Chandan K. Sen, Kanhaiya Singh, Meijing Wang
Publikováno v:
J Mol Cell Cardiol
Background Heart transplantation, a life-saving approach for patients with end-stage heart disease, is limited by shortage of donor organs. While prolonged storage provides more organs, it increases the extent of ischemia. Therefore, we seek to under