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Publikováno v:
Brazilian Journal of Biology, Vol 84 (2021)
Brazilian Journal of Biology, Volume: 84, Article number: e250151, Published: 22 NOV 2021
Brazilian Journal of Biology v.84 2024
Brazilian Journal of Biology
Instituto Internacional de Ecologia (IIE)
instacron:IIE
Brazilian Journal of Biology, Volume: 84, Article number: e250151, Published: 22 NOV 2021
Brazilian Journal of Biology v.84 2024
Brazilian Journal of Biology
Instituto Internacional de Ecologia (IIE)
instacron:IIE
Mammals have a limited capacity to regenerate their tissues and organs. One of the mechanisms associated with natural regeneration is dedifferentiation. Several small molecules such as vitamin C and growth factors could improve reprogramming efficien
Autor:
Xiaoli Xiong, Steven J. Gamblin, Jie Zhang, Sébastien G. Vachieri, Stephen R. Martin, John J. Skehel
Publikováno v:
Cold Spring Harbor perspectives in medicine. 11(10)
Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus at
Autor:
Maria G. Masucci
Publikováno v:
Seminars in Cell & Developmental Biology. 132:185-192
The covalent attachment of ubiquitin and ubiquitin-like polypeptides to cellular and viral proteins regulates numerous processes that enable virus infection, viral genome replication, and the spread of viruses to new hosts. The importance of these pr
Autor:
Lee Wisner, Alanna Maguire, Katie R. Zellner, Colleen Ramsower, Lisa M. Rimsza, Michael S. McGrath, Betty Glinsmann-Gibson, Brandon T. Larsen
Publikováno v:
Biopreservation and Biobanking. 20:473-484
Background: Formalin-fixed, paraffin-embedded (FFPE) tissues are a valuable resource for clinical and basic science research. Paraffin blocks and the resulting unstained sections (USS) are often st...
Publikováno v:
ACS chemical neuroscience. 13(15)
Effectively presenting epitopes on immunogens, in order to raise conformationally selective antibodies through active immunization, is a central problem in treating protein misfolding diseases, particularly neurodegenerative diseases such as Alzheime
Publikováno v:
Cold Spring Harb Perspect Med
Leukemias and lymphomas acquire the capacity for unrestrained cell growth and proliferation in conjunction with loss of responsiveness to molecular programs that promote terminal differentiation. Malignant cells generate the building blocks required
Autor:
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Publikováno v:
Am J Respir Cell Mol Biol
RationalePulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Facto
Autor:
Zhenkun Lou, Jake A. Kloeber
Publikováno v:
Seminars in Cancer Biology. 85:164-184
The acquisition of DNA damage is an early driving event in tumorigenesis. Premalignant lesions show activated DNA damage responses and inactivation of DNA damage checkpoints promotes malignant transformation. However, DNA damage is also a targetable
Autor:
Wei Liu, Zhiqiang Yu, Zhi Chen, Kun Liu, Xiaomei Ye, Chaobo Huang, Dudu Wu, Kangrui Yuan, Yuyun Li
Publikováno v:
IEEE Transactions on NanoBioscience. 21:549-559
Lycorine-nanoparticles (LYC-NPs) were successfully synthesized using anti-solvent precipitation-freeze drying method, and characterized using transmission electron microscopy (TEM), particle size analysis and Fourier transform infrared spectroscopy (
Autor:
Evgeniy Panzhinskiy, Haoning Cen, Timothy J. Kieffer, Mark O. Huising, Søs Skovsø, James D. Johnson, Xiaoke Hu, Honey Modi, Derek A. Dionne, Yiwei Bernie Zhao, Shouhong Xuan, Nicole A.J. Krentz, Nilou Noursadeghi, Cara E. Ellis, Francis C. Lynn, Yi Han Xia, Chieh Min Jamie Chu
Publikováno v:
Diabetes. 71:2612-2631
Heterogeneity within specific cell types is common and increasingly apparent with the advent of single cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β cells of the endocrine pan