Zobrazeno 1 - 10
of 27
pro vyhledávání: '"B. Glick"'
Autor:
Daniel J. Hayes, Cong Chen, Jacob T. Bailey, Shue Li, Adam B. Glick, Mohammad Abu-Laban, Yiming Liu
Publikováno v:
Biomaterials
Despite evidence that microRNAs (miRNAs) are essential in modulating tumorigenesis, a major challenge in cancer treatment is to achieve tumor-specific selectivity and efficient yet safe delivery of miRNAs in vivo. In this study, we have developed a l
Publikováno v:
Carcinogenesis. 35:959-966
Transforming growth factor beta 1 (TGFβ1) is a pleiotropic cytokine in the skin that can function both as a tumor promoter and suppressor in chemically induced skin carcinogenesis, but the function in ultraviolet B (UVB) carcinogenesis is not well u
Autor:
Combiz Khozoie, Christina H. Ferry, Frank J. Gonzalez, Adam B. Glick, Jeffrey M. Peters, Bokai Zhu, Nicholas Blazanin, Moses T. Bility
Publikováno v:
Molecular and Cellular Biology. 32:2065-2082
The role of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in Harvey sarcoma ras (Hras)-expressing cells was examined. Ligand activation of PPARβ/δ caused a negative selection with respect to cells expressing higher levels of the Hras
Autor:
Adam B. Glick, Kelly A. Hogan, Rolando Perez-Lorenzo, Lauren Mordasky Markell, Stuart H. Yuspa
Publikováno v:
Carcinogenesis. 31:1116-1123
Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin che
Autor:
Adam B. Glick, Roshini M. Ponnamperuma, Kathryn E. King, Tamador Elsir, Geoffrey M. Wahl, Wendy C. Weinberg, Monica Nistér
Publikováno v:
The Journal of Pathology. 219:263-274
Transcriptional regulation by p53 is critical for p53-mediated tumour suppression; however, p53-mediated transactivation has been dissociated from p53-mediated biological processes including apoptosis, DNA repair, and differentiation. We compared the
Autor:
Charles Vinson, Julian M. Rozenberg, Vikas Rishi, András Orosz, Adam B. Glick, Jaideep Moitra
Publikováno v:
Mol Cancer Res
We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using t
Autor:
Moses T. Bility, Meghann K. Devlin-Durante, Adam B. Glick, Jerrold M. Ward, Mary J. Kennett, Frank J. Gonzalez, Jeffrey M. Peters, Nicholas Blazanin, Boo Hyon Kang
Publikováno v:
Carcinogenesis. 29:2406-2414
Peroxisome proliferator-activated receptor (PPAR)β/δ-null mice exhibit enhanced tumorigenesis in a two-stage chemical carcinogenesis model as compared with wild-type mice. Previous work showed that ligand activation of PPARβ/δ induces terminal di
Publikováno v:
Molecular Cancer Research. 6:509-516
Cripto-1 is an epidermal growth factor-Cripto/FRL1/Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors. Here we report that in the two-stage mouse skin carcinogenesis model, Cr
Autor:
Adam B. Glick, Nicholas A. Frost, Michelle R. Levy, Vikas Rishi, Jaideep Moitra, Charles Vinson, Stuart H. Yuspa, Maxim V Myakishev, Michael J. Gerdes, Sang Won Park, Asha Acharya
Publikováno v:
Cancer Research. 66:7578-7588
To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding.
Autor:
Craig D. Woodworth, Evan Michael, Henry Hennings, Kinnimulki Vijayachandra, Stuart H. Yuspa, Adam B. Glick, Laura Smith
Publikováno v:
Carcinogenesis. 25:1771-1778
The multistage evolution of squamous skin tumors induced by chemical or viral carcinogens on mice from different genetic backgrounds has been a valuable model to define low penetrance loci that determine cancer susceptibility or resistance. Susceptib