Zobrazeno 1 - 10
of 22 387
pro vyhledávání: ''
Autor:
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Publikováno v:
Am J Respir Cell Mol Biol
RationalePulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Facto
Autor:
Tong, Lei, Zhuangzhuang, Xiao, XiaoShuang, Zhang, Shanglin, Cai, Wangyu, Bi, Yanjie, Yang, Donghui, Wang, Quanhai, Li, Hongwu, Du
Publikováno v:
Cytotherapy. 24:1105-1120
Gingival mesenchymal stem cells (GMSCs) demonstrate high proliferation, trilineage differentiation and immunomodulatory properties. Parkinson disease (PD) is the second most common type of neurodegenerative disease. This study aimed to explore the ef
Autor:
Shiwen Deng, Tong Lei, Hongyu Chen, Huiting Zheng, Zhuangzhuang Xiao, Shanglin Cai, Zhongci Hang, Weini Xiong, Yanqing Yu, Xiaoshuang Zhang, Yanjie Yang, Wangyu Bi, Hongwu Du
Publikováno v:
Cytotherapy. 24:1095-1104
Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabet
Autor:
Raffaela Silvestre Ignarro, André Luis Bombeiro, Gabriela Bortolança Chiarotto, Luciana Politti Cartarozzi, Lilian de Oliveira Coser, Enrico Ghizoni, Helder Tedeschi, Fernando Cendes, Iscia Lopes-Cendes, Fabio Rogerio, Alexandre Leite Rodrigues de Oliveira
Publikováno v:
Differentiation. 128:43-56
Major histocompatibility complex class I (MHC-I) has been implicated in several types of neuroplasticity phenomena. Interferon beta-1b (IFN-β) increases MHC-I expression by motoneurons after sciatic nerve crush in mice, improving axonal growth and f
Autor:
Kristijonas Žemaitis, Agatheeswaran Subramaniam, Roman Galeev, Aurel Prosz, Maria Jassinskaja, Jenny Hansson, Jonas Larsson
Publikováno v:
Experimental Hematology. 115:20-29
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifier
Autor:
Tharshika Thavayogarajah, Dzmitry Sinitski, Omar El Bounkari, Laura Torres-Garcia, Hadas Lewinsky, Alexander Harjung, Hong-Ru Chen, Jens Panse, Lucia Vankann, Idit Shachar, Jürgen Bernhagen, Steffen Koschmieder
Publikováno v:
Experimental Hematology. 115:30-43
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of small, mature CD5
Autor:
Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo
Publikováno v:
Analytical Cellular Pathology. 2022:1-12
Background and Purpose. Breast cancer ranks first in the incidence of female tumors. Triple-negative breast cancer (TNBC), one type of breast cancer, is more aggressive and has a worse prognosis. Demethylzeylasteral (T-96) is isolated from Tripterygi
Publikováno v:
Human Cell. 36:1-14
In vitro culture of human limbal epithelial stem cells (hLESCs) is crucial to cell therapy in the treatment of limbal stem cell deficiency, a potentially vision-threatening disease that is characterized by persistent corneal epithelial defects and co
Autor:
Sebastian E. Koschade, Kevin Klann, Shabnam Shaid, Binje Vick, Jan A. Stratmann, Marlyn Thölken, Laura M. Meyer, The Duy Nguyen, Julia Campe, Laura M. Moser, Susanna Hock, Fatima Baker, Christian T. Meyer, Frank Wempe, Hubert Serve, Evelyn Ullrich, Irmela Jeremias, Christian Münch, Christian H. Brandts
Publikováno v:
Leukemia 36, 2396-2407 (2022)
Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25 % of acute myeloid leukemia (AML) patients, drive leukemia progression and confer a poor prognosis. Primary resistance to FLT3 kinase inhibitors (FLT3i) quizartinib,
Publikováno v:
Cytotherapy. 24:827-834
Chimeric antigen receptor (CAR) T-cell therapy can be associated with significant toxicities. CAR-engineered natural killer (NK) cells provide a safer alternative while maintaining anti-tumor effects. Activated NK (aNK) cells are a clinical-grade cel