Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Jeremy N. Rich"'
Publikováno v:
Nature Cancer. 2:584-586
Despite substantial advances in understanding of the molecular features of gliomas, the therapeutic options for these aggressive tumors remain scarce. Rich, Mitchell and colleagues provide their views about a phase 1 clinical trial testing the safety
Autor:
Paul S. Mischel, Sihan Wu, Wei Zhang, Jeremy N. Rich, Andrey Rzhetsky, Jun Tang, Frank B. Furnari, Harley I. Kornblum, Aaron M. Armando, Ryan C. Gimple, Ellis J. Curtis, Atif Ali Khan, Derek A. Wainwright, Shunichiro Miki, Briana C. Prager, Timothy F. Cloughesy, Junfeng Bi, Huijun Yang, Oswald Quehenberger, Benjamin F. Cravatt, Tomoyuki Koga
The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify SMPD1, an enzyme that regulates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fda624483f82009e300e8d49f6b882f
https://doi.org/10.1101/2021.03.16.435487
https://doi.org/10.1101/2021.03.16.435487
Autor:
Alex Reed, Ryan C. Gimple, Derek A. Wainwright, Timothy F. Cloughesy, Atif Ali Khan, Jeremy N. Rich, Harley I. Kornblum, Tomoyuki Koga, Huijun Yang, Jun Tang, Frank B. Furnari, Junfeng Bi, Benjamin F. Cravatt, Yuchao Gu, Paul S. Mischel, Oswald Quehenberger, Ivy Tsz-Lo Wong, Hui Jing, Shunichiro Miki, Briana C. Prager, Aaron M. Armando, Andrey Rzhetsky, Ellis J. Curtis, Sihan Wu, Wei Zhang
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109957-(2021)
Summary The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodiest
Autor:
Sadie Johnson, Rachel Schafer, Shaun Stauffer, Jonathan Macdonald, Gustavo Roversi, Justin D. Lathia, Joseph Alvarado, Erin E. Mulkearns-Hubert, Anjali Kashyap, Jeremy N. Rich, Adam Lauko, Christopher Goins, Kristen Kay, Daniel J. Silver, Kelly Mitchell, Steven Martinez, Christopher G. Hubert
Publikováno v:
Neuro Oncol
Glioblastoma (GBM) progression and resistance to conventional therapies is driven in part by cells within the tumor with stem cell properties including quiescence, self-renewal and drug efflux potential. It is thought that eliminating these cancer st
Autor:
Tong Hu, Luciano Mazzoccoli, Jeremy N. Rich, Sachendra S. Bais, Michael S. Diamond, Milan G. Chheda, Hideho Okada, Pei Yong Shi, Arijita Jash, Jennifer Govero, Camila R. Fontes-Garfias, Sujan Shresta, Sharmila Nair, Chao Shan
Publikováno v:
JCI insight, vol 6, iss 1
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus (ZIKV) targets GBM stem cells and prevents death of mice with gliomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70a1ddc1d5cb1ac10ad87cd9a425e2b
https://escholarship.org/uc/item/00x665sr
https://escholarship.org/uc/item/00x665sr
Autor:
Eleni A. Skokos, Jocelyn Wiggins, Maureen Fagan, Susan L. Greenspan, Pamela W. Duncan, Patricia C. Dykes, Neil B. Alexander, Can Meng, Fred C. Ko, Lillian Min, Jeremy N. Rich, Todd M. Manini, Lori Goehring, Heather G. Allore, Siobhan K McMahon, Thomas M. Gill, Joanne M. McGloin, Jeanne A. Teresi, David B. Reuben, Peter Peduzzi, Albert W. Wu, Shehzad Basaria, Rosaly Correa-de-Araujo, Denise Esserman, Chad Boult, Nancy K. Latham, Neil M. Resnick, Erich J. Greene, Elena Volpi, Thomas G. Travison, Katy L. B. Araujo, Martha B. Carnie, Carri Casteel, Michael E. Miller, Jay Magaziner, Charles Lu, Stephen C. Waring, Robert B. Wallace, Thomas W. Storer, Peter Charpentier, David A. Ganz, Jerry H. Gurwitz, Catherine Hanson, Priscilla K. Gazarian, Shalender Bhasin, James Dziura
Publikováno v:
Journal of the American Geriatrics Society, vol 69, iss 1
J Am Geriatr Soc
J Am Geriatr Soc
Author(s): Gill, Thomas M; Bhasin, Shalender; Reuben, David B; Latham, Nancy K; Araujo, Katy; Ganz, David A; Boult, Chad; Wu, Albert W; Magaziner, Jay; Alexander, Neil; Wallace, Robert B; Miller, Michael E; Travison, Thomas G; Greenspan, Susan L; Gur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa522b2d0309b2187690903d926c16df
https://escholarship.org/uc/item/1r4709ck
https://escholarship.org/uc/item/1r4709ck
Autor:
Harish N. Vasudevan, Javier Villanueva-Meyer, Kyounghee Seo, Zhixin Qiu, Michael Martin, David A. Solomon, David R. Raleigh, N. Butowski, Tai-Chung Lam, Abrar Choudhury, Michael W. McDermott, Gilberto Kai-Kit Leung, Arie Perry, Penny K. Sneed, Stephen T. Magill, Briana C. Prager, Siyuan Liu, Jessica Schulte, Matthew S. Susko, Calixto-Hope G Lucas, Jeremy N. Rich, Jason Y. Chang, Joseph F. Costello, Charlotte Eaton, Joanna J. Phillips, Steve Braunstein, Michael Zhang, Jenny Kan-Suen Pu, Nancy Ann Oberheim Bush, Lai-Fung Li, Mitchell S. Berger, William C. Chen
Meningiomas arising from the meningothelial central nervous system lining are the most common primary intracranial tumors, and a significant cause of neurologic morbidity and mortality1. There are no effective medical therapies for meningioma patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6100cdca7b7e7f0976087a175630fc6
https://doi.org/10.21203/rs.3.rs-113172/v1
https://doi.org/10.21203/rs.3.rs-113172/v1
Publikováno v:
Neurosurgery. 67
Autor:
Pei Yong Shi, Michael P. Diamond, Luciano Mazzoccoli, Sujan Shresta, Sharmila Nair, Milan G. Chheda, Jeremy N. Rich, Tong Hu, Arijita Jash, Jennifer Govero
Publikováno v:
Neuro Oncol
GBM is a hallmark example of an immunotherapy-resistant tumor. Previously, we discovered that Zika virus (ZIKV) has a natural honing capacity to specifically kill GBM stem cells (GSCs). Using two syngeneic glioma models, GL261 and CT2A, we found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855625f38ba3c6f6bd2a397755514743
https://europepmc.org/articles/PMC7651684/
https://europepmc.org/articles/PMC7651684/
Autor:
Katerina Kraft, Robert J. Wechsler-Reya, Abhijit Chakraborty, Jill P. Mesirov, Derek Reid, Michael D. Taylor, Jesse R. Dixon, Frank Buchholz, Rocio Acuna-Hidalgo, Hannah Carter, Kristian W. Pajtler, Sachin Kumar, John R. Crawford, James T. Robinson, Ferhat Ay, Edwin F. Juarez, Stefan Mundlos, Kulandaimanuvel Antony Michaelraj, Konstantin Okonechnikov, Lukas Chavez, Denise M. Malicki, Nicole G. Coufal, Jens-Martin Hübner, Jeremy N. Rich, Till Milde, Matija Snuderl, Stefan M. Pfister, Donglim Esther Park, Owen Chapman, Anthony P. Schmitt, Michael J. Levy, Aylin Camgoz, Sahaana Chandran, Marcel Kool, Rosalind Bump, Shareef Nahas, Monika Mauermann, Meghana Pagadala
Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial RELA-fusion associated group and the posterior fossa ependymoma group A. In both groups, tumors occur mainly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdcce4993578ea10426937ff57727149
https://doi.org/10.21203/rs.3.rs-88331/v1
https://doi.org/10.21203/rs.3.rs-88331/v1