Zobrazeno 1 - 10
of 63
pro vyhledávání: '"David Lyden"'
Autor:
David Lyden, Laura Pisarsky, Cyrus M. Ghajar, Irina Matei, Sun-Young Lee, Serena Lucotti, Mina J. Bissell, Jinxiang Dai, Ryann E Shor
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 130-147 (2022)
Dormant, disseminated tumor cells (DTCs) are thought to be the source of breast cancer metastases several years or even decades after initial treatment. To date, a selective therapy that leads to their elimination has not been discovered. While dorma
Autor:
Neal Rosen, Kathryn C. Arbour, David Lyden, Valerie W. Rusch, Bob T. Li, Gaetano Rocco, Gregory J. Riely, Prasad S. Adusumilli, Brooke Mastrogiacomo, Raul Caso, Sandra Misale, Rona Yaeger, Alexander Drilon, Smita Sihag, Matthew J. Bott, Piro Lito, James G. Connolly, Yuan Liu, Yonina R. Murciano-Goroff, Kay See Tan, David R. Jones, Daniela Molena, Gregory D. Jones, James M. Isbell, Francisco Sanchez-Vega, Haiying Zhang, Charles M. Rudin
Publikováno v:
Clin Cancer Res
Purpose: KRAS G12C is the most common KRAS mutation in primary lung adenocarcinoma. Phase I clinical trials have demonstrated encouraging clinical activity of KRASG12C inhibitors in the metastatic setting. We investigated disease-free survival (DFS)
Autor:
Etienne Meylan, David R. Jones, Navneet Narula, Jinxiang Dai, Shahin Rafii, Yuan Liu, Henrik Molina, Irene Casanova-Salas, Han Sang Kim, Irina Matei, David J. Pisapia, Alberto Benito-Martin, Quincey LaPlant, Joshua K. Sabari, Milica Tesic Mark, David Lyden, Candia M. Kenific, Daniela Freitas, Sandra J. Shin, Xinran Jiang, Nasser K. Altorki, Yonathan Ararso, Katharine Offer, Paula S. Ginter, Brian D. Dill, Loïc Steiner, Vinagolu K. Rajasekhar, Brunilde Gril, Huajuan Wang, Maria de Sousa, Gonçalo Rodrigues, Chaitanya R. Badwe, Héctor Peinado, Shizhen Emily Wang, Tyler M. Lu, Bruno Costa-Silva, Haiying Zhang, Patricia S. Steeg, Cyrus M. Ghajar, Ayuko Hoshino, Weston Buehring, John H. Healey, Charles M. Rudin, Peter R. Oxley, Linda Bojmar, Ilana Scandariato, Jacqueline Bromberg
Publikováno v:
Nature cell biology, vol 21, iss 11
Nat Cell Biol
Nat Cell Biol
The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic coloniz
Publikováno v:
Nature Cell Biology. 23:111-113
Anorexia commonly develops in patients with advanced cancer and is closely associated with cachexia. A new study shows that anorexia emerges earlier than cachexia in both Drosophila and mouse tumour models and that tumour-derived humoral factors indu
Autor:
Laura Pisarsky, Serena Lucotti, Cyrus M. Ghajar, Jinxiang Dai, Sun-Young Lee, Irina Matei, David Lyden, Ryann E Shor, Mina J. Bissell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97db98951db49dcb38af28232e31b83
https://doi.org/10.1002/1878-0261.13031/v2/response1
https://doi.org/10.1002/1878-0261.13031/v2/response1
Autor:
Raghu P. Kataru, Babak J. Mehrara, Catherine L. Ly, Hyeung Ju Park, Sagrario Ortega, David Lyden, Jung Eun Baik, Jinyeon Shin, Sonia Rehal
Publikováno v:
Cancer Immunology Research. 7:1345-1358
Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in lymphatic function result in accumulation of inflammatory cells with an immunosuppressive profile.
Autor:
Marc Ladanyi, William D. Travis, Matthew J. Bott, David Lyden, Yuan Liu, Axel Martin, Nikolaus Schultz, Kay See Tan, Prasad S. Adusumilli, Michael F. Berger, Gregory J Riely, Francisco Sanchez-Vega, Gaetano Rocco, David R. Jones, Whitney S. Brandt, Jamie E. Chaft, Marcin Imielinski, Bob T. Li, Daniela Molena, Ronglai Shen, Bernard J. Park, Ariana Adamski, David B. Solit, Marty W. Mayo, Natasha Rekhtman, Gregory D. Jones, Jian Zhou, Hira Rizvi
Publikováno v:
JAMA Surg
IMPORTANCE: Recommendations for adjuvant therapy after surgical resection of lung adenocarcinoma (LUAD) are based solely on TNM classification but are agnostic to genomic and high-risk clinicopathologic factors. Creation of a prediction model that in
Autor:
Nicole D. Houston, Seth M. Steinberg, Scott L. Carter, Dee Dee K. Smart, Mark R. Gilbert, Terri S. Armstrong, Nadia Biassou, Brunilde Gril, Priscilla K. Brastianos, David Lyden, Eric M. Burton, Patricia S. Steeg, Alexandra S Zimmer, Stanley Lipkowitz
Publikováno v:
Future Oncol
Brain metastases occur in up to 25–55% of patients with metastatic HER2-positive breast cancer. Standard treatment has high rates of recurrence or progression, limiting survival and quality of life in most patients. Temozolomide (TMZ) is known to p
Autor:
E. Popa, David Lyden, Sorin Alexandrescu, N.I. Luca, Doru Paul, V.M. Croitoru, I. Sandra, Irina M. Cazacu, I-M. Gramaticu, Andrei Sorop, Irina Matei, Mircea Diculescu, Adina Croitoru, Simona Dima, C. Gheorghe, D. Bogdan, I.M. Dinu, Vlad Herlea, Irinel Popescu
Publikováno v:
Annals of Oncology. 32:S1371
Autor:
Kofi Ennu Gyan, Han Sang Kim, Haiying Zhang, Irina Matei, Ayuko Hoshino, Linda Bojmar, David Lyden
Publikováno v:
Cancer Research. 81:IA024-IA024
In 1889, Stephen Paget first proposed that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. A growing number of studies demonstrate that tumor-derived microv