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Autor:
Braulio Rojas, Mario Herrera-Marschitz, David Vásquez, Diego Lagos, Mario Rivera-Meza, María Elena Quintanilla, Yedy Israel
Publikováno v:
Neuropharmacology. 146
A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alco
The effects of various manipulations of brain 5-HT mechanisms on the behavioural responses induced by the selective NK-3 tachykinin agonist senktide in rodents were assessed. Senktide elicited wet dog shakes in the rat which were attenuated by the 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bfccde08c7e4e4537e319e5d9d672d
https://doi.org/10.1016/0006-8993(90)91015-9
https://doi.org/10.1016/0006-8993(90)91015-9
Publikováno v:
Brain Research, 1398(8), 13-20. ELSEVIER SCIENCE BV
In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3 h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient te
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:61-70
A number of potential neuroleptic drugs of the substituted benzamide type have been compared with some reference neuroleptic drugs regarding their affinities for rat brain receptors using in vitro receptor binding techniques. The effects on dopamine-
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:88-91
The effect of manganese on free polysomal protein synthesis of immature rat brain (3 weeks old) has been determined after 1, 2, 3, and 4 weeks of daily intake of 55 micrograms manganese/ml of drinking water. The protein synthesis was inhibited up to
Autor:
Nils-Erik Andén, Helmut Wachtel
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:310-320
Baclofen (beta-parachlorophenyl-GABA) caused an increase in the concentration of dopamine in the rat brain with a maximum of about 170% of the control value after 1 hr and after doses of 50 mg/kg or more intraperitoneally. The alpha-methyltyrosine-in
Autor:
R. Klysner, A. Geisler
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:1-5
Lithium (5 and 20 mM) was found to inhibit the dopamine-stimulated cyclic AMP formation in homogenates from rat striatum and olfactory tubercle, leaving basal and fluoride-stimulated activities unaffected. The inhibition of dopamine-stimulated adenyl
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:270-277
Intravenous injection of soman in the rat produced a rapid and dose related increase in blood pressure. The dose response curve was very steep, threshold responses occurring after intravenous injection of 10 micrograms/kg, and maximum increases of ab
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:354-363
Female rats were given 16% ethanol solution as the sole liquid during the entire period of gestation. At birth the offspring was removed and reared by foster dams consuming normal tap water. The development of sensory motor behaviour and emotional re
Autor:
John Hyttel
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:439-446
Changes in endogenous concentrations of 5-HT and 5-HIAA as well as the turnover rate of 5-HT was studied in rat brain after treatment with a new potent and selective inhibitor of the neuronal 5-HT reuptake mechanism, Lu 10–171 (1-(3-(dimethylamino)