Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jain R"'
Autor:
Stylianopoulos, T., Jain, R. K.
Publikováno v:
Nanomedicine: Nanotechnology, Biology, and Medicine
Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the fact that the enhanced perm
Autor:
Stylianopoulos, Triantafyllos, Economides, Eva Athena, Baish, J. W., Fukumura, D., Jain, R. K.
Publikováno v:
Annals of Biomedical Engineering
Ann.Biomed.Eng.
Ann.Biomed.Eng.
Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable preferential delivery to tumor
Autor:
Baish, J. W., Stylianopoulos, T., Lanning, R. M., Kamoun, W. S., Fukumura, D., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascula
Publikováno v:
Annual Review of Biomedical Engineering
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells' inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31342236a2aef544510573096a5bb0b9
http://gnosis.library.ucy.ac.cy/handle/7/48436
http://gnosis.library.ucy.ac.cy/handle/7/48436
Publikováno v:
Annals of Biomedical Engineering
Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To overcome this outstanding pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc730d29ca6f0378388cccf29ceffa0
http://gnosis.library.ucy.ac.cy/handle/7/48867
http://gnosis.library.ucy.ac.cy/handle/7/48867
Autor:
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., PopoviÄ, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., Jain, R. K.
Publikováno v:
Nature Nanotechnology
Nature nanotechnology
Nature nanotechnology
The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapiesĝwhich ĝ̃ normalizeĝ™
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff36aa98fca5ceee00f40737332d879c
http://gnosis.library.ucy.ac.cy/handle/7/48289
http://gnosis.library.ucy.ac.cy/handle/7/48289
Autor:
Vakoc, B. J., Lanning, R. M., Tyrrell, J. A., Padera, T. P., Bartlett, L. A., Stylianopoulos, T., Munn, L. L., Tearney, G. J., Fukumura, D., Jain, R. K., Bouma, Brett E.
Publikováno v:
2010 IEEE Photonics Society Winter Topicals Meeting Series, WTM 2010
In vivo imaging technologies drive the development of improved cancer therapies by revealing critical aspects of the complex pathophysiology of solid tumors in small animal models[1]. The abnormal vascular function, which predicts tumor malignant pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51af13c7e70d5199e703a64ed66d659
http://gnosis.library.ucy.ac.cy/handle/7/48912
http://gnosis.library.ucy.ac.cy/handle/7/48912
Autor:
Melody A. Swartz, Paolo A. Netti, Alan J. Grodzinsky, Yves Boucher, Rakesh K. Jain, Christian Brekken, Arja Kaipainen
Publikováno v:
Journal of Biomechanics. 32:1297-1307
Interstitial fluid movement is intrinsically linked to lymphatic drainage. However, their relationship is poorly understood, and associated pathologies are mostly untreatable. In this work we test the hypothesis that bulk tissue fluid movement can be
Publikováno v:
Microvascular Research. 53:128-141
The growth of tumors and their response to treatment are determined by delivery of diffusible substances to cancer cells and hence by their blood supply. Relative to most normal tissues, tumor blood flow is highly heterogeneous. Several hypotheses ha
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
CIÊNCIAVITAE
Scopus-Elsevier
CIÊNCIAVITAE
We have developed a new technique to measure in vivo tumour tissue fluid transport parameters (hydraulic conductivity and compliance) that influence the systemic and intratumoral delivery of therapeutic agents. An infusion needle approximating a poin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7810161f36ffa873522954ccf7db94e5
http://hdl.handle.net/11588/154998
http://hdl.handle.net/11588/154998