Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sergio Valente"'
Autor:
Clemens Steegborn, Chunbo He, Fang Yu, Antonello Mai, Kuldeep S. Attri, Sarika Chaudhary, Eric Verdin, Ping Lan, Tuo Hu, Sergio Valente, Surendra K. Shukla, Audrey J. Lazenby, Enza Vernucci, Ravi Thakur, David A. Tuveson, Divya Murthy, Xiao Fu, Nicholas J Mullen, Dante Rotili, Ryan J. King, Pankaj Singh, Dezhen Wang, Kamiya Mehla, Marco Tafani, Scott E. Mulder, Robin High, Kanupriya Jha, Johan Auwerx, Nina V. Chaika, Kasturi Siddhanta, Camila G. Pacheco
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarci
Autor:
Dante Rotili, Paola Vianello, Annalisa Romanelli, Stefania Vultaggio, Davide Corinti, Mario Varasi, Oronza A. Botrugno, Claudia Binda, Nicola Mautone, Sergio Valente, Anna Cappa, Antonello Mai, Clemens Zwergel, Elisabetta Di Bello, Paola Dessanti, Andrea Mattevi, Saverio Minucci, Rossella Fioravanti, Annarita Rovere, Ciro Mercurio
Publikováno v:
ChemMedChem
LSD1 is a lysine demethylase highly involved in initiation and development of cancer. To design highly effective covalent inhibitors, a strategy is to fill its large catalytic cleft by designing tranylcypromine (TCP) analogs decorated with long, hind
Autor:
Licheng Zhu, Wenhu Duan, Jinrong Min, Kongkai Zhu, Shijie Fan, Giulia Stazi, Clemens Zwergel, Xiangqian Kong, Hualiang Jiang, Kaiyan Zhao, Daohai Du, Yuanqing Li, Naixia Zhang, Yuanyuan Zhang, Yanli Liu, Kehao Zhao, Sergio Valente, Zhongyuan Luo, Yiluan Ding, Dandan Xu, Jingqiu Liu, Cheng Luo, Kaixian Chen
Disruption of EZH2-embryonic ectoderm development (EED) protein-protein interaction (PPI) is a new promising cancer therapeutic strategy. We have previously reported the discovery of astemizole, a small-molecule inhibitor targeting the EZH2-EED PPI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7769f96723b0c2c58a9cf6ad8b9e50a
http://hdl.handle.net/11573/1550470
http://hdl.handle.net/11573/1550470
Publikováno v:
Journal of Medicinal Chemistry
Epigenetics is nowadays a well-accepted area of research. In the last years, tremendous progress was made regarding molecules targeting EZH2, directly or indirectly. Recently tazemetostat hit the market after FDA-approval for the treatment of lymphom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69155e75b57af29a69fbd97848202bc2
http://hdl.handle.net/11588/865398
http://hdl.handle.net/11588/865398
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry, Vol 8 (2020)
Numerous and different types of cancers possess the dysregulation of the mevalonate pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to reduce lipid levels, subsequently have been discovered to exhibit anti-cance
Autor:
Luciano Nicosia, Amir Hosseini, Roberto Ravasio, Mario Varasi, Elena Ceccacci, Iros Barozzi, Roberto Dal Zuffo, Pier Luigi Rossi, Antonello Mai, Andrea Mattevi, Lorenzo Fornasari, Giulio Pavesi, Sergio Valente, Tiziana Bonaldi, Rossella Fioravanti, Saverio Minucci, Ciro Mercurio
Publikováno v:
Science Advances
The study addresses the mechanism through which inhibition of LSD1 sensitizes AML cells to retinoic acid–induced differentiation.
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for t
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e21f74fb940f8b32ccb4940a73ed332
http://hdl.handle.net/10044/1/81260
http://hdl.handle.net/10044/1/81260
Autor:
Antonello Mai, Giada Del Baldo, Sergio Valente, Silvia Pomella, Rossella Rota, Biagio De Angelis, Dante Rotili, Rossella Fioravanti, Matteo Cassandri
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Cyclin-Dependent Kinases (CDKs) are well-known reliable targets for cancer treatment being often deregulated. Among them, since the transcription-associated CDK9 represents the sentry of cell transcriptional homeostasis, it can be a valuable target f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc97391a777654747064e0b4faa3ad8
http://hdl.handle.net/11573/1434640
http://hdl.handle.net/11573/1434640
Autor:
Friso S. Aalbers, Antonello Mai, Sara Marchese, Francesca Magnani, Andrea Mattevi, Sergio Valente, Joana Reis, Federica Corana, Marta Ceccon, Marta Massari
Publikováno v:
Redox Biology
Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biology, Vol 32, Iss, Pp-(2020)
NADPH-oxidases (NOXs) purposefully produce reactive-oxygen-species (ROS) and are found in most kingdoms of life. The seven human NOXs are each characterized by a specific expression profile and a fine regulation to spatio-temporally tune ROS concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89a292ed50f754a272686201467bd1a
http://hdl.handle.net/11573/1390390
http://hdl.handle.net/11573/1390390
The polypharmacology strategy of multi-targeting drugs acting on different biological pathways is capturing the researchers' attention, particularly in cancer. The simultaneous inhibition of two or more targets by drug combination or by a single 'hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a53b9c4a96ad01347c52a810b779bc
http://hdl.handle.net/11573/1416968
http://hdl.handle.net/11573/1416968
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783030429812
Since 2000, the histone methyltransferases that catalyze the methylation of a number of histone and nonhistone substrates have been discovered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e62bc6f89d7214998edc4a265871205
http://hdl.handle.net/11573/1382317
http://hdl.handle.net/11573/1382317