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Autor:
Nahla Gamal, Abdel-Rahman N. Zekri, Nadia El-Guendy, Reem Mebed, Nahla Shehata, Yasser B.M. Ali, Salwa Sabet
Publikováno v:
Current Molecular Medicine. 22:374-383
Background: Bevacizumab (Bev) resistance is hypothesized to be overcome by combining inhibitors of other signalling pathways. Objective: We aimed to study the effect of combining Bev with knocked down β-catenin (Bev-β-cat-siRNA) on the expression o
Publikováno v:
Molecular Therapy. 30:2078-2091
Zika virus (ZIKV), a flavivirus associated with neurological disorders, constitutes a global health threat. During pregnancy, ZIKV traverses the placenta and causes congenital disease such as microcephaly and Guillain-Barre syndrome in newborns. To d
Autor:
Barbara Mankel, Colleen Ramsower, Leonie Frauenfeld, Franziska Otto, Itziar Salaverria, Falko Fend, Magda Pinyol, Natalia Castrejon-de-Anta, Olga Balagué, Julia Salmeron-Villalobos, Annika Katharina Mayer, Elias Campo, Lisa M. Rimsza, Sebastian Streich, Julia Steinhilber, Joan Enric Ramis-Zaldivar, Leticia Quintanilla-Martinez, Irina Bonzheim
Publikováno v:
Blood Advances. 6:2361-2372
Diffuse large B-cell lymphoma (DLBCL) with aberrant coexpression of CD10+BCL6+MUM1+ (DLBCL-AE), classified as germinal center B cell (GCB) type by the Hans algorithm (HA), was genetically characterized. To capture the complexity of DLBCL-AE, we used
Autor:
Anouck Becker, Valentina Galata, Georges Pierre Schmartz, Eckart Meese, Jörn Walter, Andreas Keller, Sascha Tierling, Jacqueline Weiland, Laura Gröger, Andreas Schwiertz, Nadja Grammes, Marcus M. Unger, Gudrun Wagenpfeil, Hannah Philippeit, Nicole Ludwig, Klaus Faßbender, Jörg Spiegel
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:274-287
The composition of the gut microbiome is linked to multiple diseases, including Parkinson’s disease (PD). Bacteria producing short-chain fatty acids (SCFAs) and fecal SCFA concentrations are reduced in PD. SCFAs exert various beneficial functions i
Autor:
Ching-Cheng Huang
Publikováno v:
Current Gene Therapy. 22:162-167
Background: Scaffold-based gene therapy provides a promising approach for tissue engineering, which was important and popular as it combined medical applications and engineering materials’ knowledge. Objective: The decellularization techniques were
Autor:
Haowu Jiang, Katherine Beattie, Wenqin Luo, Mayank Gautam, Barbara A. Miller, Minghong Ma, Qin Liu, Mary K. MacVittie
Publikováno v:
J Invest Dermatol
Contact dermatitis (CD), including allergic and irritant CD, are common dermatological diseases and are characterized by an erythematous rash and severe itch. In this study, we investigated the function of TRPC3, a canonical transient receptor potent
Publikováno v:
Journal of the Formosan Medical Association. 121:841-847
Background/Purpose Viruses-bacteria synergistic interaction is associated with destructive periodontal diseases. However, the underlying mechanism for tissue destruction is not fully elucidated. In this study, lipopolysaccharide from Porphyromonas gi
Publikováno v:
Physiol Rev
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities that has coincided with an ever increasing sophistication of
Autor:
Zhang, Xiaoai, Zhai, Qingzhi, Wang, Jinfeng, Ma, Xiuling, Xing, Bo, Fan, Hang, Gao, Zhiying, Zhao, Fangqing, Liu, Wei
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:322-333
A more complete profiling of vaginal microbial communities and their variability enables a more accurate description of women microbiome. However, there is a distinct lack of information regarding the Chinese women. Composition of the vaginal microbi
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1102-1110
Background: Despite emerging research on new treatment strategies, chemotherapy remains one of the most important therapeutic modalities for cancers. Imidazopyridines are important targets in organic chemistry and, given their numerous applications,