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pro vyhledávání: ''
Autor:
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Publikováno v:
Am J Respir Cell Mol Biol
RationalePulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Facto
Autor:
Sibasish Mohanty, Pallavi Mohapatra, Omprakash Shriwas, Shamima Azma Ansari, Manashi Priyadarshini, Swatismita Priyadarsini, Rachna Rath, Mahesh Sultania, Saroj Kumar Das Majumdar, Rajeeb Kumar Swain, Rupesh Dash
Publikováno v:
Oncogene. 41:4929-4940
Cisplatin, 5FU and docetaxel (TPF) are the most common chemotherapy regimen used for advanced OSCC. However, many cancer patients experience relapse, continued tumor growth, and spread due to drug resistance, which leads to treatment failure and meta
Publikováno v:
Current Gene Therapy. 22:319-330
Background: Female fertility refers to the capacity to produce oocytes and achieve fertilization and pregnancy, and it is impaired by age, disease, environment and social pressure. However, no effective therapy that restores female reproductive abili
Autor:
Jian Wang, Zichao Feng, Zhaoyang Zhong, Qichao Qi, Wenjie Li, Jiwei Wang, Ning Yang, Qing Zhang, Bin Huang, Chen Qiu, Xiaofei Liu, Yaotian Hu, Anjing Chen, Wenxing Jin, Wenjing Zhou, Zhiyi Xue
Publikováno v:
Cell Cycle
Background: Nucleolar and spindle associated protein 1 (NUSAP1) is an indispensable mitotic regulator, which has been reported to be involved in the development, progression, and metastasis of several types of cancer. Here, we investigated the expres
Autor:
Douglas C. Fredericks, Hyeong Hun Choe, Ino Song, James A. Martin, L.R. Jaidev, Dongrim Seol, Marc J. Brouillette, Aliasger K. Salem, Hongjun Zheng, Emily B Petersen
Publikováno v:
Hum Gene Ther
Objective Lubricin, a glycoprotein encoded by the proteoglycan 4 (PRG4) gene, is an essential boundary lubricant that reduces friction between articular cartilage surfaces. The loss of lubricin subsequent to joint injury plays a role in the pathogene
Background Isolation of neurons from the adult mouse CNS is important in order to study their gene expression during development or the course of different diseases. New methods Here we present two different methods for the enrichment or isolation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758d54fb5b09d0bcddad86dfaf1e28d
Autor:
Kozo Kaibuchi, Masaki Sone, Yoshiya Kawaguchi, Shinichiro Taya, Yusuke Seto, Kentaro Ichijo, Shogo Aida, Tomoo Owa, Tomoki Nishioka, Mariko Yamashita, Mikio Hoshino, Satoshi Miyashita
Publikováno v:
EMBO J
During development, neural progenitors are in proliferative and immature states; however, the molecular machinery that cooperatively controls both states remains elusive. Here, we report that cyclin D1 (CCND1) directly regulates both proliferative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d1bcf7b666b0b1d0234a2005dfebe1
https://europepmc.org/articles/PMC10106980/
https://europepmc.org/articles/PMC10106980/
Publikováno v:
Differentiation. 125:35-44
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Lung resident mesenchymal stem cells (LR-MSCs) are im
Autor:
Mathieu J.F. Crupi, Douglas J. Mahoney, Rebecca C. Auer, Sarah Tucker, Adrian Pelin, D. William Cameron, Taylor R Jamieson, Ricardo Marius, John C. Bell, Réjean Lapointe, Kyle Potts, Nikolas T. Martin, Zaid Taha, Ragunath Singaravelu, Taha Azad, Jean-François Cailhier, Joanna Poutou, Bradley Austin, Jean-Simon Diallo, Emily E.F. Brown, Jack Whelan, Christiano Tanese de Souza, Sarwat T. Khan, Reza Rezaei, Julia Petryk, Carolina S. Ilkow, Stephen Boulton, Jonathan B. Angel, Jaahnavi Dave, Xiaohong He, Abera Surendran
Publikováno v:
Molecular Therapy
The coronavirus disease 2019 (COVID-19) pandemic requires the continued development of safe, long-lasting, and efficacious vaccines for preventive responses to major outbreaks around the world, and especially in isolated and developing countries. To
Autor:
Haowu Jiang, Katherine Beattie, Wenqin Luo, Mayank Gautam, Barbara A. Miller, Minghong Ma, Qin Liu, Mary K. MacVittie
Publikováno v:
J Invest Dermatol
Contact dermatitis (CD), including allergic and irritant CD, are common dermatological diseases and are characterized by an erythematous rash and severe itch. In this study, we investigated the function of TRPC3, a canonical transient receptor potent